Receptor binding
Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6
... its receptor binding activity was ...acid receptor; no binding to the mammalian ␣2-6-linked sialic acid receptor was ...H13 receptor binding specificity was revealed by ...
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Substitutions in the Receptor-Binding Domain of the Avian Sarcoma and Leukosis Virus Envelope Uncouple Receptor-Triggered Structural Rearrangements in the Surface and Transmembrane Subunits
... during receptor-triggered activation of EnvA, with the RBD in SU playing a central role in coupling the activation ...wild-type receptor binding yet are defective for entry) are very ...CD4 ...
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CdiA Effectors Use Modular Receptor Binding Domains To Recognize Target Bacteria
... The location of the receptor-binding region has implications for the structure and presentation of CdiA on the inhibitor cell surface. CdiA effectors are thought to be structurally similar to the FhaB ...
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Paramyxovirus Receptor-Binding Molecules: Engagement of One Site on the Hemagglutinin-Neuraminidase Protein Modulates Activity at the Second Site
... activities: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion ...both binding and neuraminidase, and the receptor mimic, zanamivir, impairs viral entry ...
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Characterization of the Prototype Foamy Virus Envelope Glycoprotein Receptor-Binding Domain
... Env receptor- binding ...cellular receptor molecules for FVs have eluded ...to receptor binding, which is dif- ferent in insect cells, has been assessed until ...
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Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition
... by binding to terminal sialic acid (SA) residues on host ...HA receptor binding site (RBS), suggesting that substitutions associated with an- tigenic drift may also influence receptor ...on ...
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Regulation of interferon receptor expression in human blood lymphocytes in vitro and during interferon therapy
... by binding to specific receptors on the cell surface. The binding characteristics of IFN to human lymphocytes were studied using IFN alpha 2 labeled with 125I to high specific ...specific binding ...
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In silico approach designing and modeling anti cd4 and gp120 drug candidate to block hiv infection
... is a stacked double barrel that lies alongside the inner domain so that the outer barrel and inner bundle axes are approximately parallel. The proximal barrel of the outer-domain stack is directional b-sheet that is ...
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Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors
... Since binding events are extracted via visual cues from the video, we next filtered out ambiguous binding events, such as floating virions or false particles (bright pixels from shot noise that resemble ...
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Chemical and analytical aspects of radioligand development for quantitative neuroimaging
... ligand binding site and an intrinsic ion channel gated by the neurotransmitter (Figure ...1.5A).^ Receptor binding results in a conformational change in the receptor and the opening o f the ...
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Preferential localization of systemically administered radiolabeled interleukin 1alpha in experimental inflammation in mice by binding to the type II receptor
... The binding of human recombinant IL-1 to murine leuko- cytes, predominantly PMNs, has also been described by Parker et ...the binding of radiolabeled IL-1 to these cells ex ...show binding of ...
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Nuclear magnetic resonance studies of insulin-like growth factor-I analogues displaying enhanced biological activity
... While the binding detenninants in IGF-I, important for type 2 IGF receptor binding, are different from those required for maintaining high affinity for the type 1 IGF receptor, this regi[r] ...
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Discovery of Check Point Kinase 1 (Chk1) Inhibitors as Potential Anticancer Agents Using Ligand-Based Modelling and Virtual Screening
... the binding features in Hypo1/4 , Hypo11/5 and Hypo28/6 with ligand-receptor binding interactions anchoring inhibitors into Chk1's binding pocket, we compared the pharmacophoric features of ...
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Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction Angiotensin II stimulates the release of vasorelaxants
... AT1 receptor antagonist losartan competed in a monophasic manner for all the specific binding, suggesting that the non-AT1/non-AT2 recognition site identified using autoradiography may be a cytosolic ...
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Evaluation of the Biological Properties and Cross-Reactive Antibody Response to H10 Influenza Viruses in Ferrets
... the receptor-binding preference of avian H10 viruses and suggests that some H10 viruses carry previously unidentified combi- nations of amino acid changes that may permit binding to ␣ 2,6-linked ...
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Injury affects coelomic fluid proteome of the common starfish, Asterias rubens
... High-throughput transcriptomic and proteomic approaches targeted on non-model invertebrates have often revealed novel proteins that lack database matches or conserved domains that would allow for speculation about their ...
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Characterization of the Interaction of Lassa Fever Virus with Its Cellular Receptor α-Dystroglycan
... -DG binding (30, ...Virus binding to ␣ -DG was blocked in a dose-dependent manner with increasing concentrations of laminin-1 and laminin-2, but not fibronectin, which does not use ␣ -DG as a ...
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PubMedCentral-PMC5321036.pdf
... the receptor, are mainstays of cardiovascular medicines used to treat a wide variety of illnesses ...specific receptor conformations for biophysical ...
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Characterisation of the binding of leukotriene B4 to macrophages of the rainbow trout Oncorhynchus mykiss
... of receptor, termed B-LT (Metters, ...the receptor are interconvertible; for example, the receptor can be converted from high to low affinity by treatment with GTP analogues (Sherman et ...
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New developments in the treatment of HER2-positive breast cancer
... Neratinib (HKI-272; Pfizer Inc, New York, NY) is an irreversible pan-ErbB small molecule receptor tyrosine kinase inhibitor. It covalently binds to the cysteine residue in the adenosine triphosphate–binding ...
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