Receptor Specificity
Changing the Receptor Specificity of Anthrax Toxin
... native receptor-binding function and fused epidermal growth factor (EGF) to the C terminus of the mutated ...EGF receptor (A431 cells), but not into a line lacking this receptor (CHO-K1 ...toxin ...
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Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses
... Glycan array analysis has become a standard assay to assess influenza A virus receptor specificity (6, 11, 12), since it probes numerous biologically important glycans within a single assay. Glycan array ...
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Receptor Specificity of Influenza A H3N2 Viruses Isolated in Mammalian Cells and Embryonated Chicken Eggs
... Our results from the BR07 egg-isolated high-growth reas- sortants can shed light on virus-host interactions in this system. The X-171A clone had a single change (Leu194Pro), while the X-171B clone had two amino acid ...
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Deletions of neuraminidase and resistance to oseltamivir may be a consequence of restricted receptor specificity in recent H3N2 influenza viruses
... Results: Influenza H3N2 isolates A/Oklahoma/323/03 (Fujian-like), A/Oklahoma/1992/05 (California-like), and A/Oklahoma/309/06 (Wisconsin-like) lost NA activity on passage in MDCK cells due to internal deletions in the ...
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Basis for receptor specificity of nonecotropic murine leukemia virus surface glycoprotein gp70SU.
... The chimeric MuLVs were tested for receptor specificity by testing HaSV pseudotypes for superinfection interference on NIH 3T3 cells previously infected with either ecotropic, MCF, ampho[r] ...
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Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic
... in receptor specificity then would affect cell tropism and possibly the virulence of these viruses (12, 27), but it also may reduce its ability to transmit (46), as reflected in its vastly reduced ...on ...
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Envelope Determinants for Dual-Receptor Specificity in Feline Leukemia Virus Subgroup A and T Variants
... a receptor. In some cases, such as FeLV-T, a nonclassical receptor that includes both a transport protein (Pit1) and a soluble cofactor (FeLIX) is required for ...confer specificity to classical ...
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Novel Receptor Specificity of Avian Gammacoronaviruses That Cause Enteritis
... The binding of S1 proteins of enteric and respiratory CoVs to the intestinal epithelium (this study) and the tracheal and lung epithelia (5), respectively, was in agreement with the reported in vivo pathotypes of avian ...
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Critical Glycosylated Residues in Exon Three of Erythrocyte Glycophorin A Engage Plasmodium falciparum EBA 175 and Define Receptor Specificity
... IMPORTANCE Plasmodium falciparum uses distinct ligands that bind host cell receptors for invasion of red blood cells (RBCs) during malaria infection. A key entry pathway involves P. falciparum EBA-175 (PfEBA-175) ...
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Altered receptor specificity of coxsackievirus B3 after growth in rhabdomyosarcoma cells.
... 5A indicated that expomultiplicity of 1,000 PFU per cell before attachment of the CB3 sure of HeLa cells to high levels of CB1 blocked the parent 0, CB3-RD 0, and PT2 x; B cells preincub[r] ...
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T-cell receptor specificity maintained by altered thermodynamics
... Previous analyses have shown TCRs can use a range of dif- ferent thermodynamic strategies to bind to pMHC, although favorable enthalpy, most likely mediated through the formation of new bonds during ligation, is the most ...
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Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells
... SA receptor was regulated during differentiation. This receptor was present in preciliated mouse cells (prior to cilium growth) and did not require foxj1, a factor required for localization of other apical ...
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Structure Analysis of the Major Capsid Proteins of Human Polyomaviruses 6 and 7 Reveals an Obstructed Sialic Acid Binding Site
... Human polyomavirus 6 (HPyV6) and HPyV7 are commonly found on human skin. We have determined the X-ray structures of their major capsid protein, VP1, at resolutions of 1.8 and 1.7 Å, respectively. In polyomaviruses, VP1 ...
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Characterization of a bacteriophage related to R-type pyocins.
... Mapping and receptor specificity indicate that PS17 of pyocin R2 factor by conjugttion.. Mishares some common feature with PS3 and Rcrobiol.[r] ...
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... Influenza A viruses are classified into different sub- types based on the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). The initial step in the influenza infection is the binding of HA to sialylated ...
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Identification of highly conserved domains in hemagglutinin associated with the receptor binding specificity of influenza viruses: 2009 H1N1, avian H5N1, and swine H1N2
... illustrated the most conserved positions in the HA1 se- quences of each subtype (Figures 5, 7, and 10). The ISM bioinformatics technique was applied to the three con- sensus HA1 sequences as presented in Figure 2 to un- ...
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Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
... chemokine receptor CXCR4 (also named fusin or Lestr) and the C-C chemokine receptor CCR5 as the principal entry cofactors for T-cell-line-tropic and non-T-cell-line-tropic HIV-1, ...chemokine ...
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Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain.
... cellular receptor which mediates binding is unknown, although there is evidence suggesting that two distinct adenovirus receptors interact with the group C (adenovirus type 5 [Ad5]) and the group B (Ad3) ...
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Effects of Receptor Binding Specificity of Avian Influenza Virus on the Human Innate Immune Response
... viral receptor specificity in promoting innate immune responses in humans, we generated recombinant influenza viruses, one bearing the HA and neuraminidase (NA) genes from the A/Vietnam/1203/2004 H5N1 HPAIV ...
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Receptor binding specificity of recent human H3N2 influenza viruses
... Our data show that the change to chicken red cell aggluti- nation ability of recent human clinical H3N2 isolates is not associated with a change in receptor specificity to α2- 3-sialic acid. We see no ...
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