recombinant human interferon gamma
Evaluation of expression systems of recombinant human interferon gamma
... is recombinant human interferon gamma ...that recombinant hIFNγ therapy is beneficial, safe and well-tolerated to chronic hepatitis C-infected patients (Kokordelis et al, 2014; Muir et ...
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Demonstration and partial characterization of the interferon gamma receptor on human mononuclear phagocytes
... Radioiodinated recombinant human interferon-gamma (IFN gamma) bound to human monocytes, U937, and HL60 cells in a specific, saturable, and reversible ...IFN gamma, and ...
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The effect of process variables on the glycosylation of gamma-interferon produced in CHO (Chinese hamster ovary) cells
... f human therapeutics become more stringent the ability to monitor product authenticity is given greater ...a human protein o f therapeutic use, was chosen as a suitable model ...produced recombinant ...
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Inducible Expression of Human Gamma Interferon
... Construction of recombinant plasmid (pMPGB 43P2(6)K-IFN-γ. The resulting PCR product, the 558 base-pair (bp) of HuIFN-γ coding sequence containing restriction sites of BamHI enzyme and expressing vector ...
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Recombinant interleukin 2 and gamma interferon act synergistically on distinct steps of in vitro terminal human B cell maturation
... of recombinant interleukin 2 (IL-2) on the in vitro differentiation of human tonsillar B cells which were not preincubated with Staphylococcus aureus Cowan I or with anti- human IgM were ...that ...
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Organ specific cytokine therapy Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon gamma to the human lung
... activate human alveolar macrophages in vivo. To accomplish this, rIFN-gamma was administered to nonsmoking normals, the amounts of IFN-gamma quantified in serum and respiratory epithelial lining ...
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Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes
... the human hepatitis B virus (HBV), the woodchuck hepatitis virus (WHV), and the duck hepatitis B virus ...that interferon gamma (IFN-g) and tumor necrosis factor alpha (TNF-a), induced in the liver ...
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Vaccinia Virus Vectors with an Inactivated Gamma Interferon Receptor Homolog Gene (B8R) Are Attenuated In Vivo without a Concomitant Reduction in Immunogenicity
... the gamma interferon (IFN- ␥ ) ...including human and rat IFN- ␥ ; it does not, however, bind significantly to murine IFN- ␥ ...of recombinant VVs (rVVs) lacking the B8R ...
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Influence of recombinant bovine gamma interferon on neutrophil function
... Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-monocyte colony-stimulating[r] ...
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Gamma Interferon Treatment of Patients with Chronic Granulomatous Disease Is Associated with Augmented Production of Nitric Oxide by Polymorphonuclear Neutrophils
... A multicenter study showed that recombinant human gamma interferon (IFN-g) administered subcutaneously (s.c.) three times a week significantly reduced serious infections (17). This regimen has ...
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Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
... of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine ...a recombinant vaccinia virus boost in BALB/c mice, CON6 env gp120 and gp140CF elicited gamma ...
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Lymphoproliferative and Gamma Interferon Responses to Stress-Regulated Mycobacterium avium subsp. paratuberculosis Recombinant Proteins
... His-tagged recombinant proteins at the Faculty of Veterinary Science, University of Sydney, Sydney, Australia, as previously described ...express recombinant proteins. Recombinant proteins were ex- ...
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Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon Primed Human Epithelial Cells
... 3=). Human B2M DNA was detected using the following primer sequences as described previously (53): B2M forward primer (5= TGC TGT CTC CAT GTT TGA TGT ATC T 3=) and B2M reverse primer (5= TCT CTG CTC CCC ACC TCT ...
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Expression of Interferon Gamma by a Recombinant Rabies Virus Strongly Attenuates the Pathogenicity of the Virus via Induction of Type I Interferon
... between interferon gamma (IFN-␥) expression and both survival from infection with attenuated rabies virus (RABV) and reduction of neurological ...the recombinant rabies virus designated ...
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Gamma interferon inhibits collagen synthesis in vivo in the mouse
... with recombinant murine gamma-interferon (rMuIFN-gamma) to deliver 2 X 10(3) U/h for 14 d, there was a marked decrease in thickness and collagen content of the capsules from ...
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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... ABSTRACT Blood-brain barrier (BBB) breakdown is a hallmark of many diseases of the central nervous system (CNS). Loss of BBB integrity in CNS diseases such as viral encephalitis results in the loss of nutrient/oxygen ...
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Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma activated human monocytes depending upon its degree of iron saturation Iron lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila
... pneumophila intracellular multiplication in human monocytes is iron dependent and that IFN gamma-activated monocytes inhibit L. pneumophila intracellular multiplication by limiting the availability of iron. ...
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Immune specific gamma interferon production correlates with lymphocyte blastogenesis
... Gamma interferon IFN--y production, measured by a new commercially available radioimmunoassay, and lymphocyte blastogenesis were investigated in human peripheral lymphocyte cultures from[r] ...
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The talented interferon gamma
... ATP-binding cassette transporter A1 (ABCA1) is a key regulator that facilitates cholesterol efflux from ma- crophages and prevents the formation of pathological foam cells. IFN-γ has been shown to down regulate ABCA1 ...
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Treatment With Interferon Gamma Versus Interferons Alfa and Gamma in Children With Chronic Hepatitis B
... Hepatology. PorresJC, Mora I, GutiezJ, et al. Antiviral effect of recombinant gamma interferon in chronic hepatitis B virus infection: a pilot study. Marcellin P, Loriot MA, Boyer N, et [r] ...
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