recombination deficiency
Efficacy of platinum-based chemotherapy and prognosis of patients with pancreatic cancer with homologous recombination deficiency: comparative analysis of published clinical studies
... The aim of our study was to determine the effect of homologous recombination deficiency (HRD) on prognosis and efficacy of platinum- based chemotherapy in patients with pancreatic cancer (PC). We performed ...
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Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple negative breast cancer cells
... Results: Our results show that prexasertib treatment promotes both post-translational and transcriptional mediated regulation of BRCA1 and RAD51 proteins. Additionally, prexasertib-treated TNBC cells revealed over 55% ...
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Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers
... homologous recombination deficiency and drug response A genomic scar can be defined as a genomic aberration with a known ...HR deficiency, can result in an overestimate of the gravity, and hence ...
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Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents
... Fig. 6 Mutational features of HR-deficient tumor genomes. a The contribution of COSMIC signature 3 to the SNV spectrum derived from whole exome sequence data of tumors from various tissues bearing biallelic inactivating ...
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Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs
... Background: Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the ...
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Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high grade serous ovarian cancer
... The development of rapidly testable and analytically reliable biomarkers to predict susceptibility to agents targeting HR deficiency is necessary to guide optimal application of PARPi. We hypothesized that ...
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Maximal Power Tests for Detecting Defects in Meiotic Recombination
... meiotic recombination deficiency when only a limited number of meiotic progeny can be ...in recombination potential (as little as 50%) can be detected by assaying a single interval in as few as 100 ...
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Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge 2018” (28–29 November, 2018, Naples, Italy)
... Homologous recombination deficiency; ICOS: Inducible Co-Stimulator; IFN: Interferon; IgG: Immunoglobulin G; IHC: Immunohistochemistry; IL: Interleukin; IMC: Imaging mass cytometry; irRC: Immune-related ...
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Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... homologous recombination; HRD: homologous recombination deficiency; BRCA: breast related cancer antigens; gBRCAm: germline breast related cancer antigens mutation; sBRCAm: somatic breast related ...
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Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes
... repair deficiency is a hallmark of TNBC ...(homologous recombination deficiency–loss of heterozygosity (HRD-LOH) score) [11], telomeric allelic imbalance (homologous recombination defi- ...
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Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N region insertions during V(D)J recombination
... Sequence analysis of V(D)J recombinants. To examine the role of TdT in the resolution of the human V(D)J recombination reaction, N regions were analyzed at both signal and coding junctions. Jurkat (mature T) or ...
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Region-Specific Cis- and Trans-Acting Factors Contribute to Genetic Variability in Meiotic Recombination in Maize
... Thus the A188 Shl-Bzl region increases recombination frequencies only in the shl-bzl interval and does not affect recombination in the adjacent regions.. Recombination frequ[r] ...
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PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma
... homologous recombination repair (HR) deficiency and down-regulated the Spindle Assembly Checkpoint (SAC) factor BUBR1, leading to mitotic catastrophe ...HR deficiency, leading to the induction of ...
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Iron Profile in Cobalamin Deficiency: a prospective single centre based study
... peripheral blood film, serum vitamin B12 with normal iron profile. Serum iron profile was measured at presentation and after completion of therapy. We found a significant decrease in body iron store after cobalamin ...
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Role of Mismatch Repair in the Fidelity of RAD51- and RAD59-Dependent Recombination in Saccharomyces cerevisiae
... length, and the sequence differences in the inverted repeats Determination of recombination rates: Yeast colonies grown of SJR1487 are exclusively base substitutions. 2 days on YEPD were inoculated into 5 ml YEPGE ...
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Recombination of W18+ ions with electrons : absolute rate coefficients from a storage-ring experiment and from theoretical calculations
... At higher energies, autoionization into excited states becomes energetically possible and this greatly suppresses, or damps, the DR rate coefficient, as was evidenced by the IC results in Ref. [10]. However, the simple ...
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Progress in Phenylketonuria: Defects in the Metabolism of Biopterin
... Thus, there is hyperphenylalaninemia attributable to (1) phenylalanine hydroxylase deficiency, (2) DHPR deficiency, and (3) deficiency in the synthesis of tetrahydrobiopterin.. This clas[r] ...
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Inference of the Properties of the Recombination Process from Whole Bacterial Genomes
... of recombination in bacteria is linkage disequilibrium (LD) or the nonrandom association of alleles at different loci (Maynard Smith et ...more recombination events affect exclusively one or the other site, ...
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Crossing Over Is Rarely Associated With Mitotic Intragenic Recombination in Schizosaccharomyces pombe
... allelic recombination, ade6-M375 ⫻ zzz7::ade6-469 mitotic crossover recombi- and a chromosomal position effect was conserved in nants, and, for comparison, eight ade6-M26 ⫻ zzz7::ade6- mitotic and meiotic diploid ...
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Lineage specific recombination rates and microevolution in Listeria monocytogenes
... a recombination event. The recombination rates within lin- eages I and II were also inferred using ClonalFrame ...the recombination rate were calculated: ρ/θ which measures the relative frequency of ...
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