Renal interstitial fibrosis
Original Article A modified approach to establish a murine model of hypoxic renal interstitial fibrosis
... hypoxic renal interstitial fibrosis mainly includes 5/6 nephrectomy, unilateral ureteral obstruction and cyclosporin A (CsA)-induced renal interstitial ...CsA-induced renal ...
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Original Article Centella asiatica inhibits renal interstitial fibrosis by regulating Smad3 and Smad7 expression in the TGFβ signaling pathway
... on renal interstitial fibrosis, as well as Smad3 and Smad7 in a TGF-β signaling pathway mediated ...the renal tubule interstitial ...inhibited renal interstitial ...
9
Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway
... and renal interstitial fibrosis in mice induced by ...cytotoxicity, fibrosis markers, and NF-κB pathway were measured in a normal rat kidney cell line ...some renal tubules regenerated ...
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Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
... diminished fibrosis in chron- ic obstructive nephropathy by 50% ...spontaneous renal interstitial fibrosis in sham- operated kidneys ...the renal morphological lesions in the absence of ...
9
Disruption of tissue type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
... of renal interstitial fibrosis, characterized by excess matrix accumulation and deposition, is poorly ...Tubular interstitial fibrosis is often regarded as a final, common endpoint ...
15
Effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy
... protecting renal function [3] ...alleviates renal inflammatory response, regulates blood lipids, protects kidney and delays DN progression [4] ...on renal interstitial fibrosis and ...
5
Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
... in renal interstitial ...UUO-induced fibrosis [3, 4, 5, ...underlying renal interstitial ...and interstitial fibroblasts after UUO ...
10
Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
... Renal fibrosis has been shown to be a complex process involving an orchestral interaction of various molecular and cellular factors [2, ...of renal fibrosis in the UUO model [6, ...of ...
7
The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression
... Results: Our results demonstrated that Brachyury was prominently induced in TGF- β 1-treated human proximal tubular epithelial (HK-2) cells and that this induction was accompanied by changes characteristic of EMT. ...
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Original Article Pax2 expression correlates with EMT markers in an experimental model of obstructive nephropathy
... of renal interstitial collagen deposition ...in renal tubules was positively associated with α-SMA expression (r = ...the renal tubular epithelial cells following obstructive nephropathy, and ...
9
Original Article RhoA/ROCK1 signaling pathway is involved in proliferation and differentiation in human lung fibroblast cells
... RhoA has two forms, which are inactive when bound to GDP, are activated following GTP bind- ing, GTP-RhoA translocated to the plasma membrane, where it mediates downstream ROCK. Activated ROCK forms a complex with MYPT1 ...
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Grigorescu Vlass, Melissa (2018): Inflammasome-independent NLRP3 signaling in chronic kidney disease. Dissertation, LMU München: Medizinische Fakultät
... the renal pelvis (kidney stone formation) or in the collecting duct system and renal medulla like MSU crystals, calcium oxalate (in mice) and cysteine (in humans) crystallization can be found diffusely in ...
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Retrospective analysis of renal histology in asymptomatic patients with probable chronic kidney disease of unknown aetiology in Sri Lanka
... Chronic kidney disease of unknown aetiology (CKDU) is endemic among several rural farming communities in and around the North Central Province (NCP) of Sri Lanka, namely, Medawachchiya, Padaviya, Siripura, Horowpathana, ...
6
Airway-centered interstitial fibrosis: etiology, clinical findings and prognosis
... bronchiolocentric interstitial pneumonia needs to be separated from bron- chiolitis ...nonspecific interstitial pneumo- nia with a bronchiolocentric distribution; however, sev- eral cases had relevant ...
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Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice
... To assess whether treatment with Fibroferon reduces systemic side effects compared with non-targeted full length IFNγ, brain MHC class II mRNA expression (as a measure of IFNγ-induced microglia activation) and plasma ...
13
Prevalence of Hypovitaminosis D among Renal Transplant Recipients and Its Relation to Graft Interstitial Fibrosis
... By this cross-sectional study, we recruited 99 kidney transplant recipients in the nephrology department, organ transplant center in Kuwait with the following criteria: males and females, above 18 years and below ...
11
Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes
... Figure 14 summarises the diverse pathological changes (eosinophilia, airway epithelial cell injury, regenerative goblet cell hyperplasia, bronchocentric pulmonary fibro- sis, and atelectasis) induced by a single ...
16
Usual interstitial pneumonia coexisted with nonspecific interstitial pneumonia, What’s the diagnosis?
... In summary, we described one case of INSIP from gross to light microscopy for removed lung. Three main findings were as followings: (1) The existences of hetero- geneity and transmigration between these subtypes of ...
6
TGF beta 1 induced epithelial to mesenchymal transition and therapeutic intervention in diabetic nephropathy
... Developmentally, renal tubules are derived from the metanephric mesenchyme through a process termed mesenchymal-to-epithelial transdifferentiation (MET). This cellular differentiation is not static and cells ...
22
Cardiac fibrosis in the elderly, normotensive athlete: case report and review of the literature
... increased fibrosis and fat within the cardiac conduction system of elderly patients ...atrial fibrosis and decrease in nerve plexus population has also been demon- strated ...cardiac fibrosis, ...
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