repressor/activator protein 1
The shelterin complex and hematopoiesis
... factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear factor 2 (TIN2), protection of telomeres 1 (POT1), and adrenocor- tical dysplasia homolog ...
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The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0.
... In these assays we used plasmids containing the a genes encoding ICP4, ICPO, and ICP27 either singly or in combination as effectors and HSV-1 genes of different kinetic classes and heter[r] ...
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Activator and Repressor Functions of the Mot3 Transcription Factor in the Osmostress Response of Saccharomyces cerevisiae
... to 1 for the wild type at time point ...min. Protein occupancy was calculated in each case relative to the unbound POL1 control region and is depicted in comparison to the no-tag wild-type ...
12
CREB-2, a Cellular CRE-Dependent Transcription Repressor, Functions in Association with Tax as an Activator of the Human T-Cell Leukemia Virus Type 1 Promoter
... Tax protein of the human T-cell leukemia virus type 1 (HTLV-1) has been implicated in human T-cell ...a protein kinase A (PKA) phosphorylation site and has been reported to negatively regulate ...
6
Meis2 competes with the Groucho co repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain hindbrain boundary organizer
... transcriptional activator or repressor depending on the cellular ...co- repressor protein Tle4 is sufficient to attenuate Otx2 transactivation activity and leads to effective repression of an ...
12
Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response
... mammalian repressor and activator protein (Rap1, also known as telomeric repeat-binding factor 2-interacting protein 1), is a component of the shelterin complex at the telomere and ...
13
The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection.
... (lane 1), which contains only a wt p5 RBE; sub262 (lane 2), which contains neither a p5 RBE nor a TR; psub201 (lane 3), which contains both a wt TR and a wt p5 RBE; or sub262TR (lane 4), which contains a wt TR and ...
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Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
... FIG 1 Relative binding to the mtrCDE promoter of wild-type MBP-MtrA and MBP-MtrA containing mutated residues predicted to be involved in DNA ...the protein-DNA complex for the mutated MtrA ...
7
Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans
... transcriptional repressor (Nrg1) or activator (Gal4), we were able to show specific repression or activation of the tester gene CAT1, encoding the cytosolic ...fluorescent protein (GFP) and demon- ...
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The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.
... The results of these experiments showed that mutants containing insertions or deletions in the region from amino acids 262 to 406 in the carboxy-terminal half of the protein were unable [r] ...
13
Truncation of the transcriptional repressor protein Cre1 in Trichoderma reesei Rut-C30 turns it into an activator
... SDS, 1% (w/v) Triton X-100, 2 mM EDTA pH ...SDS, 1% (w/v) Triton X-100, 2 mM EDTA pH ...8.0, 1 mM EDTA, 1% (w/v) SDS). Protein-bound DNA was treated with Proteinase K (Thermo ...
18
Conversion of the LIN-1 ETS Protein of Caenorhabditis elegans from a SUMOylated Transcriptional Repressor to a Phosphorylated Transcriptional Activator
... We discovered EGL-27/MTA1 as a LIN-1-interacting protein in yeast cells. EGL-27 binds two domains in the carboxy- terminus of LIN-1 in yeast cells, and binding is independent of SUMOylation. ...
15
Analysis of Activator and Repressor Functions Reveals the Requirements for Transcriptional Control by LuxR, the Master Regulator of Quorum Sensing in Vibrio harveyi
... To determine which LuxR binding sites contribute to LuxR regulation of gene expression, we analyzed the locations of LuxR binding peaks relative to genes in the LuxR regulon, which was defined previously by microarray ...
10
In vitro antiplasmodial activity of cepharanthine
... Pathways analysis showed few differences between UT8 and T16. The most impacted function between these two experimental conditions seemed to be invasion and motility, containing two pathways under-expressed by ...
11
Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.
... We found that mutants which were defective in the activator function but not the repressor activity were able to hinder the activation function of wild-type ICP27 in cotransfection exper[r] ...
11
Uncoupling Dorsal mediated activation from Dorsal mediated repression in the Drosophila embryo
... Dorsal (DL) is a Drosophila Rel homology domain (RHD) protein that patterns the embryonic dorsoventral (DV) axis. Selective nuclear import of maternally encoded DL in the syncytial blastoderm embryo leads to the ...
6
Multiple roles and therapeutic implications of Akt signaling in cancer
... residues on the cytoplasmic tail of the activated TKRs or on their associated adaptor proteins recruit PI3K complex to the membrane by binding its p85 regulatory subunit and remov- ing the inhibitory effect of p85 ...
16
Role of TERRA in the Regulation of Telomere Length
... (MLL) protein, a histone methyltransferase, are significantly increased in ICF cells ...binding protein (MeCP2) and heterochromatin protein 1 ...
8
Allostery and Applications of the Lac Repressor
... lac repressor has been an important target for mutagenesis in order to explore how proteins use helix-turn-helix motifs to specifically bind ...lac repressor-DNA operator affinity (K RO ...
192
Multiple elements and auto-repression regulate Rox1, a repressor of hypoxic genes in Saccharomyces cerevisiae.
... Tupl-dependent repressor that repressed anaerobic ex- pression; Roxl itself that repressed its own expression; and an unidentified transcriptional activator, which is responsibl[r] ...
10