Requirement for PI3K during influenza A virus replication
Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication
... CPXV-stimulated PI3K/Akt pathway of biological relevance in spontaneously immortal- ized A31 and MEF ...and PI3K/PDK1, ...benefit virus penetration, morpho- genesis, and release, thereby increasing ...
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A Mechanism for Priming and Realignment during Influenza A Virus Replication
... A virus genome consists of eight segments of single- stranded ...influenza virus proteins PB1, PB2, and ...viral replication, the RdRp must use two promoters and two dif- ferent de novo initiation ...
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Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells.
... plays during influenza virus entry into MDCK cells has been analyzed by using the macrolide antibiotics bafilomycin A1 and concanamycin A as selective inhibitors of vacuolar proton-ATPase (v-[H 1 ...
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N protein alone satisfies the requirement for protein synthesis during RNA replication of vesicular stomatitis virus.
... reaction programmed with N mRNA alone (Fig. 4, lanes 4 and 5) showed that newly synthesized N protein assembled into nucleocapsids in the absence of any other newly synthe- sized viral p[r] ...
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Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition
... in virus particles, but it is greatly expressed in influenza virus-infected cells, especially in the late phase of ...most influenza A viruses is 230 aa, however, the length can vary from 202 ...
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Ceramide Suppresses Influenza A Virus Replication In Vitro
... IAV replication without manipulating SM and GSL ...increased replication of the virus genome (vRNA and cRNA) and synthesis of mRNA transcripts (particularly in Myr-treated cells) at 6 ...genome ...
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Autophagy Promotes Replication of Influenza A Virus In Vitro
... influenza virus minireplicon ...analyzed during the indicated time course of infection of siATG5-treated A549 cells ...the virus life cycle, NP was observed to be located mainly in the nucleus in both ...
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Infection and Replication of Influenza Virus at the Ocular Surface
... of replication in hu- man ex vivo ocular tissues and corneal or conjunctival cell monolayers, leaving the determinants of ocular tropism ...ity. Replication efficiency, in contrast, was reduced at 33°C ...
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The NB Protein of Influenza B Virus Is Not Necessary for Virus Replication In Vitro
... of influenza B virus is thought to function as an ion channel and therefore would be expected to have an essential function in viral ...absolute requirement in the viral life cycle is lacking, we ...
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Engineered Small-Molecule Control of Influenza A Virus Replication
... concern during vaccine challenge studies, which are an important step in the development and testing of novel vaccine and therapeutic strategies against ...the virus can express the tag over multiple ...
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Human host factors required for influenza virus replication.
... of influenza virus host factor requirements described here has revealed a large number of cellular proteins and biological pathways previously unknown to be involved in the influenza virus ...
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Heterologous SH3 p85β inhibits influenza A virus replication
... ST364 virus than PR8 ...that influenza A virus varied in their sensitivity to PI3K/Akt pathway due to long-time evolu- ...ST364 virus, PR8 virus was less susceptible to the ...
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DNA intercalator stimulates influenza transcription and virus replication
... the influenza viral polymerase complex can inhibit RNAPII transcription elongation, but not initiation [8], a phenomenon that is similar to the tran- scriptional arrest of ...Recently, influenza viral poly- ...
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Saikosaponin A inhibits influenza A virus replication and lung immunopathology
... Fatal influenza outcomes result from a combination of rapid virus replication and collateral lung tissue damage caused by exaggerated pro-inflammatory host immune cell ...of influenza-induced ...
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Evolutionary Targeted Discovery of Influenza A Virus Replication Inhibitors
... of influenza A NS1 proteolysis using three different pronase concentrations after incubation with drug compound D and with DMSO as vehicle ...of influenza viral ...the influenza A nuclear export ...
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Influenza A viruses and PI3K signalling
... of PI3K, it is not surprising that viruses hijack this pathway in order to support their own ...activating PI3K is a popular means of delaying virus- induced cell-death and/or ...apoptosis. ...
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A Bivalent Vaccine Based on a Replication-Incompetent Influenza Virus Protects against Streptococcus pneumoniae and Influenza Virus Infection
... of influenza virus infection, the body weights of mice inoculated with medium rapidly decreased and all mice died by day 5 after infection ...HA-KO/GFP virus showed no reduction in body weight and ...
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Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein
... of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein ...nucleus during viral ...and ...
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Role of the CM2 Protein in the Influenza C Virus Replication Cycle
... of influenza A and B viruses have been shown to play critical roles in the virus life ...of influenza A virus functions as a proton channel during the entry of the virus into ...
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Network Guided Discovery of Influenza Virus Replication Host Factors
... influenza virus replication screens are well-known concerns for network-based drug target ...of virus-host interactions and the possibility that virus-host interaction data are skewed toward ...
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