restriction factor
KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification
... viral restriction factor, ...transcription factor regulates the dynamic organization of the host chromatin structure via its ability to influence epigenetic marks and chro- matin ...host ...
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Effects of Cellular Activation on Anti-HIV-1 Restriction Factor Expression Profile in Primary Cells
... individual restriction factors or restriction factor gene families, such as APOBEC3 (8–10) or ...host restriction mechanisms and that variations in restriction factor gene ...
6
The Serum Very-Low-Density Lipoprotein Serves as a Restriction Factor against Hepatitis C Virus Infection
... The findings obtained from this study also suggest that HCV infection in humanized mice can be greatly enhanced by eliminat- ing its restriction factor VLDL from the mouse serum. Circum- stantial supporting ...
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Stimulation of NF-κB Activity by the HIV Restriction Factor BST2
... BST2 signaling is augmented by viral gene expression. The signaling function of BST2 might be united with its activity as a restriction factor if the protein functions as a “virus sensor” that triggers a ...
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Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter
... putative restriction factor against HCMV ...viral factor, the HCMV regulatory proteins inducing SPOC1 down- regulation remain to be ...candidate factor might be the viral protein kinase pUL97, ...
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Novel restriction factor RNA associated early stage anti viral factor (REAF) inhibits human and simian immunodeficiency viruses
... a restriction factor is most readily observed for REAF following its knockdown in HeLa- CD4 cells by ...This restriction is confirmed by over-expression of REAF-EGFP, resulting in a decrease in the ...
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Variable Prevalence and Functional Diversity of the Antiretroviral Restriction Factor TRIMCyp in Macaca fascicularis
... retroviral restriction factor TRIMCyp, derived from the TRIM5 gene, blocks replication at a postentry ...the restriction specificity of TRIMCyp derived from three animals of Indonesian ...TRIM5 ...
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Retroviral Restriction Factor TRIM5α Is a Trimer
... The retrovirus restriction factor TRIM5 ␣ targets the viral capsid soon after entry. Here we show that the TRIM5 ␣ protein oligomerizes into trimers. The TRIM5 ␣ coiled-coil and B30.2(SPRY) domains make ...
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The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor
... While our results do not identify how Nef antagonizes SERINC5, they emphasize a similarity between the mechanisms used by Nef to downregulate cell surface CD4 and to antagonize SERINC5. Since CD4 is not present in the ...
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Dynamic Regulation of Host Restriction Factor Expression over the Course of HIV-1 Infection In Vivo
... In order to better understand the kinetics of expression of each individual restriction factor gene in each patient over the course of disease, we created a heat map (Fig. 2C). Gene expres- sion from the ...
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Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection
... ABSTRACT It is common to fi nd that major-effect genes are an important cause of variation in susceptibility to infection. Here we have characterized natural variation in a gene called pastrel that explains over half of ...
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Human MxB Protein Is a Pan-herpesvirus Restriction Factor
... efficient restriction factor of alpha-, beta-, and ...herpesvirus restriction distinct from that against ...intracellular restriction factor that controls retrovirus as well as ...
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Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression
... cell-derived factor-1 (SDF-1) levels were 43% higher in ECs than in ...host restriction factors IFITM1 and IFITM2 and suppressed expression of RNase L and ...nate restriction factor ...
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Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity
... ABSTRACT Understanding the interactions between rabies virus (RABV) and individ- ual host cell proteins is critical for the development of targeted therapies. Here we report that interferon-induced protein with ...
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APOBEC3A Functions as a Restriction Factor of Human Papillomavirus
... a restriction factor against HPV infection, but the induction of this restriction mechanism by HPV may come at a cost to the host by promoting cancer mu- ...
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Ancient Evolutionary Origin and Positive Selection of the Retroviral Restriction Factor Fv1 in Muroid Rodents
... ABSTRACT The laboratory mouse Fv1 gene encodes a retroviral restriction factor that mediates resistance to murine leukemia viruses (MLVs). Sequence similarity be- tween Fv1 and the gag protein of the murine ...
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Characterization of an Amino-Terminal Dimerization Domain from Retroviral Restriction Factor Fv1
... ␣ restriction activity (32, 46), suggesting that, although the mode of restriction factor-capsid interaction may be common, the subsequent mechanism of Trim5 ␣ and Fv1 restriction is ...
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Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy
... host restriction machinery for avian influenza viruses may be present only in mammalian species and not in avian ...key restriction factor(s) associated with PB2 must be absent from FIG 7 Proposed ...
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Early Vertebrate Evolution of the Host Restriction Factor Tetherin
... interferon-inducible restriction factor targeting a broad range of enveloped ...that restriction of virus release is the primary function of ...
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Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor
... roviral restriction factors that are under strong positive selection, both in terms of gene copy number and sequence ...CD-independent restriction in vivo, we created strains of transgenic mice on an ...
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