Retinoblastoma gene
Transcriptional regulatory program in wild type and retinoblastoma gene deficient mouse embryonic fibroblasts during adipocyte differentiation
... global gene expression of 3T3-L1 cells during adipogenesis and identifying mole- cular mechanisms, biological processes, key enzymes, including many characterized and uncharacterized tran- scriptional regulators, ...
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A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions
... work revealed that discrete mutations in RB1, that only affect LXCXE interactions and not E2Fs, are limited to the coding region of exons 21 and 22 (Fig. 1). This is likely because the amino acids encoded by these exons ...
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AN IMMUNOHISTOCHEMICAL STUDY OF RETINOBLASTOMA GENE PRODUCT IN NORMAL, PREMALIGNANT AND MALIGNANT TISSUES OF THE UTERINE CERVIX
... The retinoblastoma gene was the first tumour suppressor gene identified that was altered not only in retinoblastomas but has been described in a wide variety of human ...The retinoblastoma ...
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The characterisation of a developmentally regulated transcription factor which complexes with the retinoblastoma gene product
... 1986). The 12S and 13S products differ by the presence o f 46 amino acids in 13S E lA (residues 140-185). Comparison of the sequences of various adenovirus serotypes allowed the identification of three conserved regions ...
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Role of the retinoblastoma gene in the initiation and progression of human cancer
... In addition, recent evidence suggests that the loss of Rb gene function is not only causally related to the development of retinoblastoma and tumors that occur as second cancers in patie[r] ...
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The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
... The present data show that HCs differentiate despite abnormal cell cycling, suggesting that HC proliferation and differentiation are uncoupled processes. Supernumerary HCs expressed a wide panel of markers characteristic ...
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Prognostic significance of retinoblastoma gene mutation in retinoblastoma eye with respect to pathological risk factors
... with retinoblastoma invasion of the optic nerve prior to me- ...human retinoblastoma cell lines isolated decades ago, providing a molecular mechanism for these earlier observations” ...RB gene ...
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Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase.
... By expressing large T antigens that are either competent or defective for pRb binding and simultaneously monitoring the fraction of transfected cells in the S phase, we were able to demo[r] ...
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Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth.
... These regions interact to form the binding sites for two classes of cellular proteins: those, such as the retinoblastoma gene product, whose association with the E1A products is specific[r] ...
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Sarcomas in hereditary retinoblastoma
... RB1 gene are well documen- ted in primary bone sarcomas [33] and soft tissue sarco- mas ...the retinoblastoma gene discusses the loss of RB1 function and cancer progression ...
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Original Article Identification of five novel RB1 gene mutations in Chinese patients with retinoblastoma
... Of the 9 mutations identified, there were 3 nonsense mutations, 4 missense mutations and 2 frameshift mutations and 5 mutations have not been reported previously. While the frequency of mutations detected varies over a ...
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Radiologic pathologic correlation Bilateral retinoblastoma with coexistent pinealoblastoma (trilateral retinoblastoma)
... (eg, retinopathy of prematurity and chronic retinal detachment), and infection (primarily endophthalmitis secondary to Toxocara ca- nis) (34). Persistent hyperplastic primary vit- reous is a congenital malformation in ...
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Analysis of gene rearrangements and protein expression of the tumour suppressor genes, RB1 and p16, in acute myeloid leukaemia: Possible roles in leukaemogenesis
... (Ogawa etal., 1994; Hebert etal., 1994; Quesnel e tal., 1995; Okuda etal., 1995; Rasool et al., 1995) showed that deletions of the p i 6 gene were commoner in ALL, especially those of T-cell lineage. This ...
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Trilateral retinoblastoma: two variations
... trilateral retinoblastoma represent variations of classical trilateral retinoblastoma in which either the tem- poral course of disease or the location of the intracranial malignant neoplasm was ...
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<p>Long Noncoding RNA SNHG16 Sponges miR-182-5p And miR-128-3p To Promote Retinoblastoma Cell Migration And Invasion By Targeting LASP1</p>
... of retinoblastoma, the expression levels of SNHG16 in 76 retinoblastoma tissues and normal retina tissues were determined using ...most retinoblastoma tissues (58/76, ...in retinoblastoma cell ...
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Efferocytosis in Retinoblastoma
... in retinoblastoma speci- men of human eye was shown for the first time in the scientific ...ferentiated retinoblastoma cells which were basophilic nucleated cells with scanty cytoplasm and the other group ...
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A clinical study of retinoblastoma.
... Retinoblastoma may be heritable or ...with retinoblastoma have a nonheritable form of the disease with a normal life expectancy if they are cured of eye ...unilateral retinoblastoma fall into this ...
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<p>Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway</p>
... primary retinoblastoma cultures exerted quite different levels of sensitivity to the combination of NK-92MI hCD16-GFP cells and ...to retinoblastoma cells is the high expression of MICB and death receptors ...
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Retinoblastoma as an Epigenetic Disease: A Proposal
... of gene expression is the mechanism through which the extraor- dinary variety of specialized cells of the body differen- tiate starting from a single undifferentiated ancestor, the relevance of epigenetic factors ...
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“Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma”
... RB1 gene promoter, analyzed by cloning and genomic sequencing after DNA sodium bisulfite conversion, demonstrated a monoallelic methylation pattern which coincides with a ...the retinoblastoma phenotype, ...
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