retinoid X receptor alpha
Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures
... farnesoid X receptor (FXR), hepatocyte nuclear factor 4 ␣ (HNF-4 ␣ ), peroxisome proliferator-activated receptor alpha (PPAR ␣ ), retinoid X receptor alpha (RXR ␣ ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Transient transfection studies were then carried out to address the functional significance of the observations de- scribed above. Figure 4A shows the reporter plasmids that were used for this analysis. In the presence ...
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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
... pleotropic receptor that can form homodimers, het- erodimers with RARs, and permissive heterodimers such as PPAR/ RXR and LXR/RXR (16), future studies are needed to discern pre- cisely which receptor ...
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
... 4 alpha; RXRA: Retinoid X Receptor alpha; FOXA1: Forkhead Box A1; FOXA2: Forkhead Box A2; ATP7B: ATPase copper transporting beta; SAHH: S‑adenosylhomocysteine hydrolase; SAH: ...
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Computational study of the potential molecular target for antibreast cancer activity of limonoid derivatives from chisocheton sp
... (Progesterone Receptor, PR), 1H9U (Retinoid X Receptor Beta, RXRβ), 5MKU (Retinoid X Receptor Alpha, RXRα), 1SJ0 (Estrogen Receptor Alpha, ERα), 1QKM ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... or retinoid X receptor-alpha (RXR-alpha) and a chloramphenicol acetyl transferase (CAT) reporter plasmid containing a retinoic acid responsive element into CV-1 cells was used to ...
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Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula
... acid X receptor (RXR_TRICYS; AF091121), Platyhelminthes Schistosoma mansoni retinoic acid receptor RXR (RXR_SCHMA; AF094759) and ...mansoni retinoid X receptor RXR-2 mRNA ...
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Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor Heterodimers
... pADH1_RXR_2A_NLS_GAL4AD_RAR.pSUR (Gene Bank AB425277) was constructed previously and used as a reporter in the modified yeast one-hybrid system [8]. The positive control of a modified one-hybrid assay were constructed by ...
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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
... acid receptor (RAR), and the associated ligands play critical roles in the generation of the ...of retinoid binding protein and ret- inoic acid binding protein are observed during the peri- natal period ...
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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
... The cytokine levels in the BAL fluid and homogenized lung were measured by ELISA as previously described [23]. All cytokine and chemokine ELISAs (R&D Systems, Minneapolis, MN, USA) were performed according to the ...
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The retinoid X receptor from mud crab: new insights into its roles in ovarian development and related signaling pathway
... Phylogenetic and sequence analysis of SpRXR. The Sequence alignment was performed with ClustalW software. GenBank accession numbers of the sequences used are: DrRXR-beta, Danio rerio (AAI62301.1); XlRXR-beta, Xenopus ...
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: House dust mite; Ag: Antigen; APC: Antigen presenting cells; TCR: T cell receptor; ...
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Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
... estrogen receptor, progesterone receptor and/or ...D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor γ (PPAR γ ) are known to ...
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Studies of the expression and function of the retinoid-x-receptor y gene in rodent embryonic development
... Clues about the function of the proteins encoded by the genes of the MyoD family came from experiments that involved their ectopic expression (forced e x p re s s io n in cells th a t do not n o rm ally ex p re s ...
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The insulin-like growth factor-binding protein (IGFBP) family and its role in obesity and cancer
... IGF receptor-dependent model (IGFBPs can act as an inhibitor, preventing the IGF/IGF-re- ceptor association and as an activator, facilitating binding with IGF receptors) and IGF receptor-independent model ...
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... Retinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of cancer development and ...
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Endosulfan-alpha Induces CYP2B6 and CYP3A4 via the Pregnane X Receptor
... pregnane X receptor (PXR) and induce the expression levels of cytochrome P450 (CYP or P450) enzymes, thereby increasing metabolic rates for steroid ...
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<p>Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer</p>
... Cyclin D1 is involved in G1/S transition, 21 but the results of cell cycle analysis showed no DTX-induced G1/S arrest, suggesting an insigni fi cant role for cyclinD1 in the combination t[r] ...
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Retinoid X receptor and peroxisome proliferator activated receptor gamma agonists cooperate to inhibit matrix metalloproteinase gene expression
... nuclear receptor at the target gene promoter and prevents the clearance of associated corepressors by proinflammatory stimuli ...SUMOylated receptor (lanes 4P and ...
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Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
... partner retinoid X receptor α (RXRα), but not RXRβ, in visceral WAT from obese humans and ...for retinoid and thyroid hormone receptors (SMRT) upon agonist ...
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