RGD peptides
![Last step enzymatic [18F] fluorination of cysteine tethered RGD peptides using modified Barbas linkers](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Last step enzymatic [18F] fluorination of cysteine tethered RGD peptides using modified Barbas linkers
... peptide conjugate with the fluorinase. This approach was good for lysine modified azido containing RGD peptides. It became an objective to develop a protocol compatible with cysteine ligation due to the ...
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In Vivo Characterization of 4 68Ga-Labeled Multimeric RGD Peptides to Image αvβ3 Integrin Expression in 2 Human Tumor Xenograft Mouse Models.
... radiolabeled RGD peptides was calculated as the fraction of injected dose per gram of tissue (%ID/g), as determined by gamma counter whilst simultaneously measuring 1% ...
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Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3
... (RGD) peptides have been a major focus because of their high affinity and selectivity for integrin α v β 3 --one of the most extensively examined target of ...
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Cell surface alterations in embryonic tissues exposed to RGD peptides: selective expression
... Int I De\' BioI 39 933 938 (1995) 933 O,igi lIal A rtirle Cell surface alterations in embryonic tissues exposed to RGD peptides selective expression JAMES W LASH", KENNETH M YAMADA2 and RUTH BELLAIRS'[.] ...
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Radiolabeled Cyclic RGD Peptides as Radiotracers for Imaging Tumors and Thrombosis by SPECT
... Radiolabeled multimeric cyclic RGD peptides as integrin αvβ3 -targeted radiotracers for tumor imaging.. A review: Integrin αvβ3 -targeted molecular imaging and therapy in angiogenesi[r] ...
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New Methods for Labeling RGD Peptides with Bromine-76
... specificity of the imaging tracers was confirmed by decreased tumor uptake after co-administration of unlabeled dimeric RGD peptides. The energy barrier of the transition state of bromination for the ...
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Quantitative analysis of complex amino acids and RGD peptides by X-ray photoelectron spectroscopy (XPS)
... and RGD-peptides presented in Figure 1, investigating the zwitterionic nature and varied side-chain groups of the amino acids and drawing attention to the potential for the analysis of oligopeptides as well ...
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Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction
... The accumulated activity of 68 Ga in tissues as measured with gamma counting is presented in Table 1. The highest 68 Ga activities were seen in the urine and kidney, indicating renal excretion as previously reported in ...
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Evaluation of 111In-Labeled Cyclic RGD Peptides: Effects of Peptide and Linker Multiplicity on Their Tumor Uptake, Excretion Kinetics and Metabolic Stability
... vein injection. Five animals were sacrificed by sodium pentobarbital overdose (~200 mg/kg) at 0.5, 1, 4, 24 and 72 h postinjection (p.i.). Blood samples were withdrawn from the heart of tumor-bearing mice. The tumor and ...
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8-26-2015 12:00 AM The Development of Cyclic RGD Peptides Stabilized Through 99mTc/Re(CO)3+
... towards peptides, for example integrins, growth hormone secretagogue receptor 1a, and gastrin releasing peptide ...1,2,3 Peptides as a class of biomolecules have many desirable properties such as rapid body ...
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Ternary Aligned Nanofibers of RGD Peptide-Displaying M13 Bacteriophage/PLGA/Graphene Oxide for Facilitated Myogenesis
... the RGD peptides play a fundamental role in cell attachment, and the RGD peptide-enriched substrates can stimulate the cell attachment [12, 13, ...the RGD peptide-containing ...GO-PLGA/ ...
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Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy
... after RGD-AuNP ...using RGD as a targeting ligand, but the effect has been previously described ...of RGD-targeted proteins and found significantly increased small intestine accumulation for ...
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Thromboerythrocytes In vitro studies of a potential autologous, semi artificial alternative to platelet transfusions
... the peptides appeared to crosslink to glycophorin ...phase RGD peptides and monoclonal antibodies indicated that the RGD peptides on the thromboerythrocytes interacted with the ...
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Integrin Targeted Delivery of Radiotherapeutics
... 31], RGD peptides and ana- logues were therefore chemically synthesized to mimic the structure of the natural ligands of integrins and used as the integrin αvβ3 targeting ...The RGD triple-peptide ...
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44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations
... these peptides (Fig. 1). Overall, 68 Ga-NODAGA-RGD revealed a more favorable tissue distribution profile than 68 Ga-DOTA-RGD, shown in previous studies as well as in the experiments presented in this ...
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Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis Identification of the participating ligands and development of inhibitory peptides
... The yeast Candida albicans is the leading cause of disseminated fungal infection in neonates, immunocompromised hosts, diabetics, and postoperative patients; Candida tropicalis is the second most frequent isolate. ...
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Engineered peptide-based nanobiomaterials for electrochemical cell chip
... i.e. RGD peptide on chip surfaces together with their effects on cell behaviors and electrochemical ...engineered RGD peptide over their homogenous thin film. The engineered RGD peptide not only ...
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Cell-adhesive RGD peptide-displaying M13 bacteriophage/PLGA nanofiber matrices for growth of fibroblasts
... tissue engineering applications by using various biodegra- dable polymers [5-7]. Poly(lactic-co-glycolic acid, PLGA), as one of synthetic biodegradable polymers, has been most extensively used in drug delivery and ...
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Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells
... the RGD-PEGylated liposomes with siRNA had larger mean particle sizes than the PEGylated ...mol% RGD-PEGylated lipo- somes showed a similar particle size distribution as mea- sured by the dynamic light ...
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Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins
... ADMET, absorption, distribution, metabolism, elimination, and toxicity; ECM, extracellular matrix; EGF, epidermal growth factor; GP, glycoprotein receptor; MIDAS, metal-ion-dependent adhesion site; MTS, medium throughput ...
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