rhBMP-2
Bioabsorbable Barrier Membrane Combined with rhBMP 2 Improved Bone Formation in an Experimental Model of Compromised Healing But Was Not Superior to rhBMP 2 Alone
... had rhBMP-2 depos- ited between the bone ends and Membrane wrapped around the osteotomy, the second group had Membrane wrapped around the osteotomy, the third group had rhBMP-2 placed between ...
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Evaluation of bone healing using rhBMP-2 soaked hydroxyapatite in ridge augmentation: a prospective observational study
... Methods: A total of 10 patients (4 males, 6 females; 58.5 ± 8.6 years) participated in this clinical research. Alveolar ridge augmentations were performed in edentulous (4 maxillary posterior, 5 mandibular posterior, and ...
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Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2
... The rhBMP-2 solution ...lyophilized rhBMP-2 (Ruibang Biological Materials ...mL rhBMP-2 ...1, 2, 4, 8, 12, 24, and 48 ...with rhBMP-2 was then precipitated ...
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Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: complications in the elderly
... Because of demographic changes and higher demands for mobility and life style, the number of elderly patients who seek help by orthopedic surgeons for lumbar path- ology is increasing. In contrast to younger patients, ...
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Comparison of two independent systematic reviews of trials of recombinant human bone morphogenetic protein-2 (rhBMP-2): the Yale Open Data Access Medtronic Project
... to rhBMP-2 began to be re- ...with rhBMP-2 use in anterior cervical spine sur- gery including dysphagia, hematoma, seroma, swelling, and the need for ...
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Bone Regeneration Enhanced by Antigen Extracted Xenogeneic Cancellous Bone Graft with rhBMP 2 in Rabbits Mandibular Defect Repair
... (AXCB/ rhBMP-2) had much better and more extensive bone regeneration than the group grafted with AXCB only, and the bone rege- neration increased over time from 4 weeks to 12 weeks after operation, which ...
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Schwartz, Daniel (2005): Development of an Aqueous Suspension of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2): Entwicklung einer wässrigen Suspension des recombinanten menschlichen Knochenwachstumsproteins-2 (rhBMP-2). Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... of rhBMP) also resulted in the induction of new cartilage and extensive osteophyte formation [Gelse et ...an rhBMP-2 impregnated collagen sponge, as demonstrated by Sellers and ...the ...
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Vertical bone regeneration using rhBMP-2 and VEGF
... After 3 months 108 dental implants were inserted into the mandible (72 implants) and the tibia (36 implants) of the 12 mini pigs. All surgery was performed under sterile conditions in a veterinary operating theatre. The ...
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Injectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study
... for rhBMP-2 administered by MIS techniques has been postulated to decrease complications and length of hospital stays ...for rhBMP-2 for spinal arthrodesis. Ideally, an rhBMP-2 ...
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Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model
... combining rhBMP-2 and expanded MSC in the carrier material fibrin or autologous ...with rhBMP-2 and expanded MSC in autologous serum induced significantly more bone formation than the booster ...
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Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
... The MTT assay was used to evaluate the influences of samples (VH/rhBMP-2/n-MZS VH/rhBMP-2/MZS, n-MZS, and MZS) on cell viability. The evaluation was conducted by culturing MG63 cells (Chinese ...
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Original Article rhBMP-2 applied as support of distraction osteogenesis: a split-mouth histological study over nonhuman primates mandibles
... The edentulous atrophic ridge can adversely affect the patient’s speech as well as their abil- ity to masticate. Currently, the dental atrophies caused by surgical resection, dental patholo- gies or trauma can withhold ...
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The effect of locally delivered recombinant human bone morphogenetic protein-2 with hydroxyapatite/tri-calcium phosphate on the biomechanical properties of bone in diabetes-related osteoporosis
... Since its discovery approximately 25 years ago, research has provided important insights into the role of BMPs and their effect on bone. Like most protein sig- naling substrates in the human body, their role is vast, ...
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Bone regenerative effect of recombinant human bone morphogenetic protein-2 after cyst enucleation
... Unfortunately, however, there have been some limi- tations to the use of rhBMP-2 despite the successful outcomes described above. These include the shorter half-life of BMP-2 and its rapid ...
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Enhancement of the effects of intermittent parathyroid hormone (1-34) by bone morphogenetic protein in a rat femoral open fracture model
... of rhBMP-2 with carrier effectively enhanced bone healing in a rat model of femoral fractures, although it was not enough to achieve complete bone union; 10 μg of rhBMP- 2 was necessary for ...
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Evaluation of a poly(lactic-acid) scaffold filled with poly(lactide-co-glycolide)/hydroxyapatite nanofibres for reconstruction of a segmental bone defect in a canine model
... Abstract: Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention. Abundant in vitro studies have proven ...
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Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases
... that rhBMP-2 treatment induces cancer cell growth and tumor cell invasion [10, 14, ...between rhBMP-2 and malignancy by reviewing 515 articles [19] found that 43 studies indicated that ...
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Analysis of socioeconomic profile of dairy farmers – practicing organic and non organic farming
... bisphosphonates, rhBMP-2, use of DFDBA in combination with Guided Tissue Regeneration, use of large membranes to cover extensive periodontal defects, adjunctive use of Enamel Matrix Protein, Guided Tissue ...
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Outcomes and complication rates of different bone grafting modalities in long bone fracture nonunions: a retrospective cohort study in 182 patients
... or rhBMP-2 comparative ...or rhBMP-2 ...recombinant rhBMP-2 remains highly controversial, particularly in light of some recent concerns regarding its question- able safety and ...
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“Evolving Trends in Biopolymer Based Drug Delivery Systems: An Overview” by Soruba Evangeline, Vickram Sundaram, Ramesh Pathy Manian, Sridharan Balasundaram, India.
... protein 2 (rhBMP-2) was studied for bone development on adult rat parietal bone, and the carrier collagen aided in the delivery of protein also it was absorbed after 8 weeks of administration whereas ...
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