RICC of U266B1 sensitive and U266B1 melphalan resistant cells
Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model
... cancer cells where genome integrity primarily relies on a main- tained G2/M checkpoint ...ant cells and BCL2 overexpression protects these cells against apoptosis, certain concentrations of ...
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Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro
... cancer cells via up-regulation of 15- LOX-1 in the absence of COX-2 ...neuroblastoma cells in a concentration- and time-depen- dent manner, while the terminal products of the arachi- donate cascade ...
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All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to Ponatinib
... both sensitive and resistant CML cell lines, whatever the mode of resistance and also on BaF3 murine B cells carrying native BCR-ABL or T315I ...
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Magnetic nanoparticle hyperthermia potentiates paclitaxel activity in sensitive and resistant breast cancer cells
... in sensitive and resistant cell ...the resistant cell line leads to sig- nificant reduction in cell survival at a low PTX concentration that, otherwise, had no ...affects cells during mitosis, ...
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Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
... Dovepress Nanoparticles for DTX delivery to drug-resistant cancer cells for tumor targeting. More importantly, the DTX-LPH showed great ability to induce apoptosis and kill cancer cells. The enhanced ...
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Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells
... In summary, our studies show for the first time that obatoclax is trapped in lysosomes. Its intralysosomal accumulation leads to the impairment of both lysosomal function and autophagic degradation capacity, inducing the ...
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Proton NMR visible mobile lipid signals in sensitive and multidrug-resistant K562 cells are modulated by rafts
... The NMR proton spectra of whole cells were obtained at 25°C on a Unity Inova spectrometer (Varian, France) working at 500 MHz. One-dimensional runs were per- formed by accumulating 128 transients of 90° pulse with ...
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Virogenic Properties of Bromodeoxyuridine-sensitive and Bromodeoxyuridine-resistant Simian Virus 40-transformed Mouse Kidney Cells
... When simian virus 40 (SV40) -transformed mouse kidney cells (mKS) were grown in the presence of susceptible indicator cells, SV40 was readily recovered from: (i) 15 transformed cell line[r] ...
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Combination Treatment of Imatinib-sensitive and -resistant BCR-ABL-positive CML Cells with Imatinib and Farnesyltransferase Inhibitors
... cells potentiation of imatinib activity could be observed. In contrast, the combination of imatinib plus L744,832 demonstrated synergism in EM3 but potentiation in the other cell lines (Figure 1). The reason for ...
9
Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
... Melanoma is a very aggressive form of skin cancer where advanced stages are generally associated with poor pa- tient survival [1]. Together with lung cancer, melanoma is characterized by the highest number of somatic ...
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Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
... Background Melanoma is a very aggressive form of skin cancer where advanced stages are generally associated with poor pa- tient survival [ 1 ]. Together with lung cancer, melanoma is characterized by the highest number ...
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Modeling malaria sensitive and resistant strains with superinfection
... blood cells where they initiate a second phase of asexual multiplication resulting into reproduction of about 8 - 16 merozoites which infect new red blood cells and destroy them ...
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Modeling malaria sensitive and resistant strains with superinfection
... blood cells where they initiate a second phase of asexual multiplication resulting into reproduction of about 8 - 16 merozoites which infect new red blood cells and destroy them ...
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Late-passage SC-1 cells resistant to N- and B-tropic viruses but sensitive to NB-tropic viruses.
... Late-passage dually resistant C-177 cells showed shorter doubling times than earlier- passage dually sensitive SC-1 cells, which might explain the rapid emergence of resistance in cell. [r] ...
5
A phenolic ester from Aglaia loheri leaves reveals cytotoxicity towards sensitive and multidrug resistant cancer cells
... T cells [11], HIV-1 infection [12], and initiation and promotion of chemically-induced cancer on mouse skin ...in resistant human cancer cells ...cancer cells in vitro and in vivo ...carcinoma ...
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Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells
... CCRF-CEM cells. Human wild-type HCT116 (p53 +/+ ) colon cancer cells as well as knockout clones HCT116 (p53 −/− ) derived by homologous recombination were a generous gift from ...U87MG cells ...
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Fractionated irradiation induced radio-resistant esophageal cancer EC109 cells seem to be more sensitive to chemotherapeutic drugs
... patients. This mode of therapy is considered to improve resection rates, increase survival time, and decrease lymph metastases. However, the 5-year survival rate with conven- tional doses of radiation alone is 0% to 10% ...
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Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells
... cancer cells, little attention has been paid to elucidate how to rationally design a multifunctional ...MCF-7 cells and DOX-resistant MCF-7/ADR cells by constructing four kinds of micelles ...
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Radiation-Resistant and Radiation-Sensitive Forms of Host Resistance to Polyomavirus
... The R r-r phenotype is based on a nonimmunological mech- anism that blocks dissemination of the virus in vivo. Neither a high level of NK cells nor a high level of antiviral interferons accounts for this form of ...
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The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F- driven cells and inhibit colony formation of primary MPN cells
... myeloid cells, bone marrow fibrosis, and risk of leukemic ...neoplastic cells in patients are largely insensitive to current anti-JAK2 therapies, effective therapies remain ...hematopoietic cells ...
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