ring-closing metathesis reaction
Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction.
... medium ring product, while the other instead forms a dimer product and/or ...RCM reaction would require pure samples of each diastereoisomer to be submitted to the reaction conditions ...
13
APPROACHES TOWARDS THE TOTAL SYNTHESIS OF BIOACTIVE MACROLIDES: LEUCASCANDROLIDE A, AMPHIDINOLACTONE A AND ASPERGILLIDE B
... Our next target was to couple both the fragments and investigate the critical ring-closing metathesis reaction. As per our investigation in Chapter I, we had followed the Yamaguchi conditions ...
17
Toward a simulation approach for alkene ring-closing metathesis : scope and limitations of a model for RCM
... under reaction conditions similar to those used for the majority of target synthesis ...maximum reaction yield could be obtained at optimal substrate concentration, with the most appropriate pre- catalyst ...
8
SYNTHESIS OF SOME CYCLITOLS AND AMINOCYCLITOLS BY USING RING CLOSING METATHESIS
... next reaction. Mixture of isomers 38 and 39 were subjected to ring closing metathesis using 5 mol% Grubbs 2 nd generation catalyst in DCM to give cyclopentene derivative 40 as major isomer ...
16
Central core Uprolides a survey of some ring closing metathesis approaches
... Corey-Chayvosky reaction which was studied under various reaction conditions to control the ...the reaction condition (using trimethylsulfoxonium iodide in ...
6
STEREOSELECTIVE TOTAL SYNTHESIS OF (-)-ASPINOLIDE, SYRIBUTINS, RING-CLOSING METATHESIS APPROACH TO THE SYNTHESIS OF ILEXLACTONE AND SYNTHESIS OF STRUCTURALLY DIVERSE COMPOUNDS VIA BAYLIS-HILLMAN REACTION
... Baylis-Hillman reaction is one of the most well studied C-C bond ...catalyzed ring-closing metathesis has been the subject of much attention in the recent years, and the development of ...
26
Mapping the potential energy surfaces for ring-closing metathesis reactions of prototypical dienes by electronic structure calculations
... for ring-closing metathesis reactions of a series of simple a,w-dienes which lead to 5–10 membered ring products, have been explored using density functional theory ...the reaction ...
12
Ring closing metathesis reactions of α methylene β lactams : application to the synthesis of a simplified phyllostictine analogue with herbicidal activity
... Ring closing metathesis (RCM) reactions of -methylene--lactams are used to construct strained 11- and 12-membered macrocycles that mimic key structural elements of phyllostictine ...
10
Synthesis of some monocyclic and bicyclic polyhydroxy nitrogen heterocyclic compounds (Azasugars)
... Grignard reaction on imines and ring- closing metathesis in construction of iminosugars here in we report the stereoselective synthesis of bicyclic azasugars (5,6), (6,6) and (6,7) such as ...
17
Phyllostictine A ring assembly via ring closing metathesis
... 3-Methylhept-2-en-1-ol (231) (100 mg, 0.78 mmol) was dis- solved in CH 2 Cl 2 (5 mL) and cooled to 0 °C. DBU (30 µL, 0.20 mmol) was added followed by CCl 3 CN (0.1 mL, 1.17 mmol) and the reaction stirred at room ...
190
Syntheses of polymers with diverse architectures via metathesis polymerization and investigation of their structure-property relationships
... Chapters 4 and 5 focus on brush polymers. Chapter 4 describes the syntheses of linear and cyclic brush polymers using ring-opening metathesis polymerization (ROMP) and REMP of macromonomers (MMs), ...
19
Practical New Strategies for Immobilising Ruthenium Alkylidene Complexes: Part I71-82
... initial reaction step with the diene substrate the active catalytic species becomes detached from the vinyl polystyrene support, acts then as a homoge- neous RCM catalyst in solution and, after all of the diene ...
12
How to Make a Mudsparkler
... In this dissertation work, two major research frontiers were explored. First, antimicrobial biomaterials were developed using natural biomass-derived chemicals. Pine rosin-derived cationic compounds and polymers were ...
177
Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents
... acquire natural product shikonin with high optical purity, asymmetric synthesis and chiral resolution were pro- posed to prepare crucial intermediates, 5,8-O-dimethyl ether of shikonin derivatives, in our group [10, 11]. ...
8
11C Labeling of the C(1) C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide 2 PET Tracer
... Positron emission tomography (PET), which uses specific probes radiolabeled with short-lived positron- emitting radionuclides ( 11 C, 13 N, 15 O, 18 F etc.), is a powerful non-invasive molecular imaging technique usable ...
10
Ultrasound-assisted self-metathesis reactions of monounsaturated fatty acids
... A viscous precipitate formed during these reactions. We assumed that this was due to molecular interactions between the ruthenium-based carbene complex and oleic acid, and concluded that some catalyst may have stuck to ...
6
Rapid, regioselective living ring opening metathesis polymerization of bio derivable asymmetric tricyclic oxanorbornenes
... ROMP of the methyl ester 4 was attempted with G3 in both THF and chloroform as solvent. The polymethyl ester was found to precipitate from the reaction mixture after ~10 min in both solvents (data not shown), ...
15
Studies Towards the total synthesis of (-)-Hennoxazole A, Passifloricin A, (+)-Cryptocarya Diacetate, and Davanones
... The primary hydroxyl group in compound 12 was selectively tosylated to give primary tosylate 32, which was further converted into iodide 33 by treating with NaI in refluxing acetone (Scheme 10). The compound 33 on ...
19
Syntheses of Polymers with Diverse Architectures via Metathesis Polymerization and Investigation of Their Structure-Property Relationships
... Polymerization of all these MMs using Ru catalyst 1 followed linear first- order kinetics (Figure 2A). GPC analyses of the polyMMs each showed narrow, monomodal peaks, and MWs increased linearly with conversion while ...
208
Ethyl Linoleate Derivatives from Olefin Metathesis as a Function of the Starting Complex and Reactivity Conditions
... olefin metathesis of EL conducted by G1 reached lower selectivity than that conducted by G2 for 24h at 50 ...olefin metathesis of EL; however, it was activated in the presence of SnCl 2 at 50 ºC for ...
11