risk allele
Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease
... 19H allele contributing to the choles- terol supersaturation of bile and the formation of choles- terol gallstones ...19H allele exhibited reduced choles- terol absorption as well ...19H risk ...
11
Knockout of the murine ortholog to the human 9p21 coronary artery disease locus leads to SMC proliferation, vascular calcification, and advanced atherosclerosis
... ancestral allele (G/G) only, 28 were found to be homozygous for the 9p21 risk allele rs1333049 (C/C), and 36 were heterozygous ...the risk allele than those of the ancestral ...
19
Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention
... one risk allele is sufficient for development of obesity and to affect obesity intervention outcomes ...two risk alleles are necessary to have an impact on BMI status and intervention outcomes in a ...
8
Higher <em>FKBP5</em>, <em>COMT</em>, <em>CHRNA5</em>, and <em>CRHR1</em> allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment
... PTSD risk alleles located within FKBP5, COMT, CHRNA5, and CRHR1 genetic loci (allele range = 0–6, mean count = ...this risk allele count remained associated with both lifetime (odds ratio = ...
9
Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset
... Genetic risk and age at menarche in 2 ...genetic risk have previ- ously been associated with earlier age at first symp- toms, we sought to understand the association between menarche and genetic ...1501 ...
8
Worldwide population differentiation at disease-associated SNPs
... that risk alleles for common complex diseases should be com- mon ...a risk allele discovered in one population is not always a strong predictor of the frequency of that risk allele in ...
10
Association between interleukin 8–251 T/A and +781 C/T polymorphisms and glioma risk
... with risk of ...a risk factor for the development of glioma ...higher risk of adult glioma than the CA and CC ge- notypes and that the risk allele of ERCC2 K751Q confered a significant ...
5
Reproductive aging associated common genetic variants and the risk of breast cancer
... conventional risk factors ...conventional risk factors across all of the studies (Table S2 of Additional file ...the risk allele frequency and the corre- sponding per-risk-allele ...
15
Thesis
... the risk allele (A) at ...major allele (C) at this location, so a point mutation, from (C) to (A), was necessary in order to create a new plasmid with the risk allele at ...
15
ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) GENE POLYMORPHISM (RS9939609) AND LIPID PROFILE IN TYPE2 DIABETIC OBESE IRAQI MALE
... of risk allele leads to a decreased HDL ...T2DM risk, where the frequency of distribution of rs9939609 among different ethnicities and its proposed association with BMI, insulin resistance and lipid ...
7
Probability Model of Allele Frequency of Alzheimer’s Disease Genetic Risk Factor
... genetics risk factors for common, complex diseases such as Type II diabetes and ...the risk is believed to be genetic with many genes usually involved ...Other risk factors include a history of head ...
6
Review Article Is apolipoprotein E4 an important risk factor for vascular dementia?
... APOE allele fre- quencies may vary across study populations, particularly in different ethnic and geographical ...added risk for the development of VaD, which would be aggravated even more in people ...
8
POLYMORPHISMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS) IN OBESITY AND TYPE 2 DIABETES MELLITUS (T2DM)
... is risk factor for the disorders, identifying the genes that are regulated by the diet may give a better insight to the diagnostics and therapeutics of both, Obesity and ...
23
Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the Apolipoprotein A5 gene
... a risk factor for the development of carotid plaque in patients with type III ...conventional risk factors in common providing a uniform back- ground in which to investigate the role of variants in ...
6
COPD in individuals with the PiMZ alpha-1 antitrypsin genotype
... Historically, AAT serum levels of 11 μ M were considered protective against emphysema [4, 9]. This was based on a variety of assumptions that included suggestions that MZ individuals are not at increased risk of ...
10
Association between miR-27a genetic variants and susceptibility to colorectal cancer
... of allele type and genotype distributions in the patients and healthy controls were performed by means of two-sided contingency tables using the χ 2 ...genotypic-specific risk were calculated using an ...
6
Buchkovich_unc_0153D_15588.pdf
... Other tested parameters demonstrated the trade-off between sensitivity and precision based on their settings, but in most cases these parameters had little effect other than to change the number of predicted imbalanced ...
148
Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV 1 Co Infection
... that patients that have achieved a RVR, or have one or no genetic risk factors should continue standard treatment. However, co- infected patients with unfavourable pre-treatment characteristics (i.e. HCV genotype ...
6
Associations between apolipoprotein E gene polymorphisms and Alzheimer’s disease risk in a large Chinese Han population
... ε2 allele lowered the risk of developing AD while ε4 increased this risk, which existed in all subgroups after the subjects were stratified by sex and AAO, with the highest OR of ...
8
Mendel and Genetics
... The next step in performing a genetic cross is determining the genotypes of the parents and the genotypes of the gametes. A heterozygous male and a heterozygous female to be crossed have the genotypes of Aa and Aa. ...
6