Ross river virus infection
Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses
... RRV infection of OA hOBs elicited consistently lower levels of IL-6 transcription compared to healthy hOBs, but its expres- sion was increased at 96 hpi (Figure ...RRV infection at 24 hpi, which peaked at ...
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Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus Infection
... mutant virus containing both these mutations (RRV-T48-nsP1-S79C;L224I) and observed an attenuated phenotype similar to that of RRV T48-nsP1 6M , indicating that these are the major attenuating ...
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Specific Ablation of Antiviral Gene Expression in Macrophages by Antibody-Dependent Enhancement of Ross River Virus Infection
... 264.7 cultures infected via the RRV-ADE pathway. Figure 3 shows the reverse transcriptase PCR (RT-PCR) analysis of gene transcription in LPS-treated (250 ng/ml) RAW cell cul- tures infected with RRV. The transcription of ...
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Infectious diseases
... In contrast to Ross River virus infection, most Barmah Forest cases lived on the north coast, were men (relative risk 1.4, p<O.02), and a greater proportion were aged 35 years or more[r] ...
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Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon Inducing RNAs
... Chikungunya virus (CHIKV) infection, both RLH and TLR family members are involved in the type I IFN response (7, ...Forest virus (SFV) and Sindbis virus (SINV) infection, RLH family ...
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Ross River Virus Glycoprotein-Pseudotyped Retroviruses and Stable Cell Lines for Their Production
... Forest virus, it has been demonstrated that membrane fusion is a low-pH-dependent process and that viral entry requires the endocytosis of bound viral particles ...Sindbis virus, however, it has been ...
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A Tyrosine-to-Histidine Switch at Position 18 of the Ross River Virus E2 Glycoprotein Is a Determinant of Virus Fitness in Disparate Hosts
... including Ross River virus (RRV), chikungunya virus (CHIKV), o’nyong-nyong virus, and Mayaro virus, are a group of mosquito- transmitted viruses with positive-sense, ...
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Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus
... within virus particles ...of virus particles, suggesting a role for the 6k proteins in viral assembly or budding (5, ...wild-type virus in a model of SINV neuropatho- genesis ...
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Ross River virus and the necessity of multi scale, eco epidemiological analyses
... Socio-economic status (SES) was only found to be an important covariate at a fine spatial resolution, and had a negative association with the RRV notifications. Socio-economic status may be reflecting housing conditions, ...
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Mosquito excreta: a sample type with many potential applications for the investigation of Ross River virus and West Nile virus ecology
... regulate virus infection of the midgut, escape from the midgut into the hemocel and associated tissues (dissemination), and finally infection of the salivary glands ...
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The non human reservoirs of Ross River virus: a systematic review of the evidence
... of virus-vector-vertebrate host interactions, there is unlikely to be a single definition suitable for all systems or for all applications ...to infection, and can produce sufficient viraemia to infect ...
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Adaptive Mutations in Sindbis Virus E2 and Ross River Virus E1 That Allow Efficient Budding of Chimeric Viruses
... more virus much more ...that virus budding is accelerated by 8 h or more by the different mutations, making it unlikely that changes in entry or other early events are responsible for the increase in ...
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Complement Contributes to Inflammatory Tissue Destruction in a Mouse Model of Ross River Virus-Induced Disease
... The histological analyses and EBD uptake studies reported here demonstrate a clear role for complement in mediating tissue injury after RRV infection. Although we cannot rule out that the differences in viral ...
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Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease
... RRV infection is regulated by C3- and CD11b-independent mechanisms and further confirm that many aspects of the RRV-induced inflam- matory response are similar in WT, C3 ⫺/⫺ , and CD11b ⫺/⫺ ...
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Molecular Genetic Study of the Interaction of Sindbis Virus E2 with Ross River Virus E1 for Virus Budding
... radiolabeled virus released from cells transfected with SIN(E2:D248Y) RNA was 60 to 100% of that released from cells transfected with SIN RNA in two different experi- ments, consistent with the results in ...
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Sindbis-Group Alphavirus Replication in Periosteum and Endosteum of Long Bones in Adult Mice
... Forest virus, and Ross River virus replicate in bone-associated connective tissue in neonatal mice, but skin and muscle are also major sites of viral replication (13, 17, 18, ...Furthermore, ...
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mBio-2018-Gralinski-e01753-18.full.pdf
... influenza virus and flavivirus infections (22, 32, ...viral infection are not well ...from infection with influenza virus (34) and, more recently, MERS-CoV ...dengue virus (38), and human ...
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Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphaviruses
... mosquito-cell-derived Ross River virus (mos-RRV) and Venezuelan equine encephalitis virus (mos- VEE) exhibited enhanced infection of primary myeloid dendritic cells (mDCs) compared to ...
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Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis
... RRV infection induces inflammation of bone and joint-as- sociated tissues and skeletal muscle of adult C57BL/6J ...RRV infection of B6 mice resulted in inflammation and pathology at any of these ...other ...
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Entry kinetics and mouse virulence of Ross River virus mutants altered in neutralization epitopes.
... for virus variants that were altered in their reactions to neutralizing monoclonal antibodies ...parent virus, whereas those altered in residue 4 showed no ...
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