SDF-1/CXCR4 axis
Osteoprotegerin regulates cancer cell migration through SDF-1/CXCR4 axis and promotes tumour development by increasing neovascularization
... We and others have previously described the effect of OPG on new blood vessel formation which may occur through angiogenesis, defined as the sprouting of endothelium from pre-existing vasculature and involves the mature ...
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Original Article SDF-1/CXCR4 axis promotes prostate cancer cell invasion and bone metastasis through p38, NF-κB and HIF-1α pathways
... factor 1 (SDF-1) and its specific receptor, CXC chemokine receptor 4 (CXCR4), are associated with tumor progression and metastasis in prostate cancer ...of ...
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Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1
... CXCL12/CXCR4 axis is considered as a potential target for cancer ...with CXCR4 inhibitors [43–45]. Since SDF-1 can induce CXCR4-positive HCC cells to metastasize [26], there has ...
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Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis
... the SDF-1/CXCR4 ...blotting. SDF-1 α and CXCR4 expressions were analyzed in xenotransplanted tumors and 348 cases by ...secreting SDF-1 α ...the SDF-1 ...
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SDF-1/CXCR4 axis enhances the immunomodulation of human endometrial regenerative cells in alleviating experimental colitis
... models. SDF-1/CXCR4 axis plays a chemotaxis role in stem/stromal cell ...of SDF-1/CXCR4 axis in the immunomodulation of ERCs on the experimental ...of ...
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Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia induced pulmonary artery smooth muscle cells by up regulating A2a receptor via the SDF 1/CXCR4 signaling pathway
... and SDF-1/CXCR4 axis both par- ticipate in vascular remodeling in many tissues and organs [14, ...the SDF-1/CXCR4 ...
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Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow- disseminated tumor cells
... feedback SDF-1-CXCR4 signaling loop, which is a frequently observed autocrine system [29] and, in this case, is likely to be initiated by CXCR4 ...The SDF-1-CXCR4 ...
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Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats
... of SDF-1, is highly expressed in BMSCs in the bone ...the SDF-1 gradient [19, ...of CXCR4 can enhance the migration ability of ...of CXCR4 in MSCs. CXCR4 overexpression ...
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Vol 68, No 1 (2016)
... chemokine SDF-1 and its main receptor CXCR4 are expressed in progenitor cells and play a pivotal role in EPC mobilization and homing (Peled et ...the SDF-1/CXCR4 axis and ...
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SDF 1/CXCR7 axis regulates the proliferation, invasion, adhesion, and angiogenesis of gastric cancer cells
... that SDF-1/CXCR7 inter- action may regulate multiple processes in gastric cancer gastric cancer invasion and tumor ...affect SDF-1-induced tumor cell proliferation, ad- hesion, and ...that ...
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Attenuation of osteoarthritis via blockade of the SDF 1/CXCR4 signaling pathway
... AMD3100 also reduced the level of GAG, MMP-13, MMP-1, and IL-1 b in synovial fluid and IL-1 b in serum. Matrix metalloproteinases (MMPs) play an important role in the extracellular matrix degradation ...
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Hypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis
... of SDF-1/CXCR4 axis in the migra- tory ability of monocytes, mononuclear cells were dis- posed with CXCR4 inhibitor (AMD3100, 1 ...
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Combination of Atorvastatin–Endurance Training Has Positive Effect on Apoptosis and Protein Expression of SDF-1α/CXCR4 Axis after Myocardial Infarction in Rat's Heart Tissue
... cognate CXCR4 receptor on the stem and progenitor cells and plays a crucial role in gathering and recruitment of stem cells into the infarcted ...that SDF-1α induced mobilization of the bone marrow-derived ...
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The homing of bone marrow stem cells is differentially activated in ischemic and valvular heart diseases and influenced by beta blockers
... oxide. SDF-1, particularly the α isoform, attracts stem cell to the lesion areas [7, 8], playing an essential role in pro- tecting and repairing the ischemic ...of SDF-1 expression in response ...
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Expression of chemokine receptors in angiosarcoma
... investigated CXCR4 and SDF-1 expres- sions in 53 patients with squamous cell carcinoma of the tongue, in which the frequency of cervical lymph node metastasis was significantly higher in those with ...
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Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo
... Background: Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated ...
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Field cancerisation in colorectal cancer
... Bioinformatic software was used to convert the output images into data for further analysis. Data normalisation was performed both within array (Lowess) and between array (Aquantile) using the Agilent microarray scanner. ...
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Original Article Estrogen receptor ESR1 promotes BMSCs cell proliferation and migration via regulation of SDF-1/CXCR4 signaling
... of SDF-1 and CXCR4 both increased in BMSCs express- ing ...of SDF-1 and CXCR4 helping to maintain healthy endometrium which could be reflected from our results that the pro- ...
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Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma
... of SDF(K1R)-KDEL was less stable in clone 10 compared with clone 30, so that enough CXCR4 reap- peared on the surface to enable the cells to ...the CXCR4 chemokine receptor in the ...toward ...
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The CXCR4/CXCR7/SDF 1 pathway contributes to the pathogenesis of Shiga toxin–associated hemolytic uremic syndrome in humans and mice
... the CXCR4/CXCR7/SDF-1 pathway in microvascular endothelium by a mechanism requiring enzymatic activity of the Stx A ...of CXCR4, CXCR7, and SDF1 were ...
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