second messenger
Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function
... In summary, we utilized the uniquely non-metabolizable nature of CO to quantitatively model the endogenous CO production required to achieve various intracellular CO concentrations, given the rapid diffusion of CO from ...
20
Inositol 1,4,5 trisphosphate and inositol 1,3,4,5 tetrakisphosphate are second messenger targets for cardioactive neuropeptides encoded on the FMRFamide gene
... Neuropeptides are now recognized as the largest and most diverse class of neurotransmitter molecules. Previous research has shown that these signalling molecules are commonly colocalized in neurones with classical ...
13
Correlates of aldosterone induced increases in Cai2+ and Isc suggest that Cai2+ is the second messenger for stimulation of apical membrane conductance
... Studies were performed on monolayers of cultured A6 cells, grown on permeable filters, to determine the second messenger system involved in the aldosterone-induced increase in electrogenic sodium transport. ...
8
The Bacterial Second Messenger cdiGMP Exhibits Promising Activity as a Mucosal Adjuvant
... The development of mucosal adjuvants is still a critical need in vaccinology. In the present work, we show that bis(3 ⴕ ,5 ⴕ )-cyclic dimeric GMP (cdiGMP), a second messenger that modulates cell surface ...
7
Integration of the Second Messenger c di GMP into the Chemotactic Signaling Pathway
... tous second messenger c-di-GMP functions to modulate chemosensory sensitivity of a bacterial chemotaxis receptor in the alp- haproteobacterium Azospirillum ...
11
Second messenger systems underlying amine and peptide actions on cardiac muscle in the horseshoe crab Limulus polyphemus
... Since cyclic AMP is important in excitatory chronotropic as well as inotropic actions of amines on the Limulus heart Groome & Watson, 1987, the relative activities of cardiac ganglion an[r] ...
20
Signalling by potassium: another second messenger to add to the list?
... a relatively small root region, thereby ensuring that the over- all root potassium nutritional status is not compromised. The root apex seems to be the most likely candidate for such a role (Box 2). First, cells in this ...
5
Comparison of a Ca(2+) gated conductance and a second messenger gated conductance in rat olfactory neurons
... Intracellular dialysis of 1 mmol l−1 Ca2+ in a standard-K+, low-Cl− internal solution ECl=−69 mV from the patch pipette into the olfactory neurons induced a sustained outward current of [r] ...
7
Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model
... Because the hypothesis that cAMP analogues enhanced cardiac preservation was borne out by the experiments described above, and knowing that elevated intracellular cAMP levels in vascular[r] ...
10
Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes Effects on activation of NADPH oxidase
... To investigate the effect ofvarious concentrations of propranolol on the generation of PLD-derived products, PA and DG, and to examine correlations between PA and/or DG and the activatio[r] ...
10
Calcium as a second messenger in developing nerve cells
... growth cone was moved into the centre of the camera view^ and the camera gain adjusted so that it was high enough for the growth cone to be clearly visible above the background noise, but low enough so that on Fluo-3 ...
194
c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress
... While the exact number of S. aureus proteins involved in c-di- AMP production and hydrolysis remains to be determined, it is certain that GdpP and DacA are involved in this process (Figure 7). Having shown that a ...
16
Neutrophil migration inhibitory properties of polyunsaturated fatty acids The role of fatty acid structure, metabolism, and possible second messenger systems
... As this function is crucial to cell accumulation at sites of inflammation, we examined the ability of PUFA to alter neutrophil locomotion, paying particular attention to fatty acid struc[r] ...
9
PIP2 as local second messenger: a critical re-evaluation
... Second, we set out to directly visualize subresolution membrane folding, using a numerical approach to in- crease the axial resolution. In these studies, we recorded stacks of images at 40- or 80-nm axial ...
112
RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
... Background: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP‑AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of ...
9
Native low density lipoprotein induced calcium transients trigger VCAM 1 and E selectin expression in cultured human vascular endothelial cells
... a second messenger to induce vascular cell adhesion molecule-1 (VCAM-1) expres- sion in human coronary artery (HCAEC) and pig aortic endothelial cells (PAEC) and VCAM-1 and E-selectin ex- pression in human ...
13
An epoxygenase metabolite of arachidonic acid mediates angiotensin II induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells
... The observations of this study and those reported earlier 10, 29, 30, 38 indicate that 5,6-EET fulfills the criteria for a second messenger 42: a 5,6-EET can be formed by the target tiss[r] ...
7
Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency A double blind, placebo controlled study
... One important finding of the present study is that growth hormone deficiency is associated with decreased systemic NO formation. Impaired NO activity has been shown to play an important role in the pathogenesis of ...
9
Regulation of Mitochondrial Function by Bioactive Sphingolipids
... Ceramide from mammalian membranes is composed of sphingosine, linked to a fatty acyl chain, varying in length from 14 to 26 carbon atoms [1]. Ceramide functions as an important second messenger in apoptosis ...
7
Non-ribose ligands for the human adenosine A1 receptor
... Within the mammalian body, communication is essential for the regulation of all physiological functions. Signaling from the extracellular environment to the cell’s interior is conducted in most cases by cell surface ...
164