Selected disease states associated to downregulated genes
Heme metabolism genes Downregulated in COPD Cachexia
... SCO104960, NCT00292552; www.eclipse-copd.com) co- hort. In ECLIPSE, phenotype data was obtained via the database of Genotypes and Phenotypes (dbGaP accession: phs001252.v1.p1) and gene expression data from the Gene ...
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Identifying disease-associated genes based on artificial intelligence
... mutated genes” (SMG) whose mutation rates are significantly higher than the background mutation rate and judge them as driver ...driver genes from clusters generated based on these seed positions ...driver ...
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Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease
... of genes in the region; 3) functional significance; and 4) linkage disequilibrium, the non- random association in the occurrence of alleles at two loci, represented by the square of the correlation coefficient ...
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Characterization of candidate genes in inflammatory bowel disease–associated risk loci
... these disease-related genes and maintain them at homeostatic ...in disease states may reflect a loss of such regulatory ...of genes that are conserved or differentially expressed across ...
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Tobacco smoking is associated with methylation of genes related to coronary artery disease
... 85 genes with an in-gene variant and 84 cis-eQTL genes (Additional file 1: Table ...CAD-related genes as provided by Illumina were included in the ana- ...were selected based on known asso- ...
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Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia.
... limitations associated with our ...expressed genes and comparison of different cortical brain regions), there was certainly variation unrelated to the disease state introduced into the differential ...
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Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk
... versus disease status and age at onset Previous risk profiling methods have calculated polygenic risk scores (PRS) using only variants that exhibit genome-wide significant associated with disease ...
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PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
... activation states will further enable us to target these cells for the treatment of neurological ...s disease (AD), possibly through limiting neuroinflammatory ...
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Original Article Analysis of underlying genes and functions associated with diabetic kidney disease
... and selected some differentially expressed path- ways, such as Cdc42 signaling, Type 1 diabet- es signaling, and vascular endothelial growth factor ...the genes and pathways associated with DKD, the ...
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Integrative analysis reveals disease-associated genes and biomarkers for prostate cancer progression
... pairwise disease phase comparison of prostate cancer was integrated with the reconstructed ...was selected for searching the core sub-networks in a large network of interactions from any pairwise ...
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Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes
... of genes as well as interacting with the epig- enome to modify chromatin and methylation ...is associated with several human diseases including end-stage renal ...
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cepip: context dependent epigenomic weighting for prioritization of regulatory variants and disease associated genes
... To investigate the relationship between informative tissue/cell type-specific chromatin marks and the regula- tory effect of variants, we selected the most significant fine-mapped eQTLs in each LD to form the ...
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FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease
... mellitus genes from false positive genes in GWASs The likelihood of harboring disease-associated variants in genes with high DER values could be used to prioritize candi- date SNPs from ...
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Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset
... were selected based on their relevance to the pathobiology of PD, which ultimately consisted of tissues from ten brain regions, whole blood, skeletal muscle, and nerve (a full list of the tissues utilized can be ...
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cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes
... To investigate the relationship between informative tissue/cell type-specific chromatin marks and the regula- tory effect of variants, we selected the most significant fine-mapped eQTLs in each LD to form the ...
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Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease
... To verify the gene chip data, four glucose and lipid metabolism-related genes were selected for qRT-PCR analyses. Primer sequences were designed by Primer Express 2.0 software according to mRNA sequences of ...
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Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
... SOCS genes do not follow a similar pattern in all ...was downregulated in about two third of breast cancer tissues compared with the corre- sponding ANCTs, it was upregulated in the remaining ...of ...
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Highly interconnected genes in disease specific networks are enriched for disease associated polymorphisms
... are associated with altered interactions between thousands of ...prioritize disease genes, which was generally applicable to complex ...interconnected genes in disease-specific networks ...
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Identification of disease states associated with coagulopathy in trauma
... Clinical consequences The Hidden Markov Model of the impact of trauma on coagulation provides an improved understanding that can shape the way we treat trauma patients. If blood data are measured for patients in an ICU, ...
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The IGF pathway is activated in insulinomas but downregulated in metastatic disease.
... Moderate to strong nuclear p-AKT expression in normal pancreatic islets 7. (D), and moderate to strong nuclear and moderate cytoplasmic expression in an 8[r] ...
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