selective cyclooxygenase-2 inhibitor
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
... highly selective cyclooxygenase-2 inhibitor DFU (5,5-dimethyl-3-(3- fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone) (Merck Frosst, Quebec, Canada) was administered orally (10 ...
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Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor
... a selective COX-2 inhibitor, in spite of the consti- tutive expression of the inducible isoform in the pan- ...another selective COX-2 inhibitor, namely DuP-697, which did not ...
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Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo
... Celecoxib may exert an inhibitory effect on the en- hanced radiation-induced G2/M arrest in the COX-2- overexpressing cells. This effect may allow the arrested cells to enter mitosis and die after radiation [31]. ...
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Selective cyclooxygenase-2 inhibitor use and progression of renal function in patients with chronic kidney disease: a single-center retrospective cohort study
... The limitations of this study include: 1) The obser- vational study design – so no kidney biopsy was used to diagnose causative renal diseases, such as acute ischemic tubular necrosis and ATIN; 2) The study did ...
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Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2
... To further improve tumor response and reduce normal tissue toxicity from radiotherapy or chemoradiotherapy, many novel approaches have investigated several agents in preclinical and clinical settings. These approaches ...
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EXPERIMENTAL ANTIBACTERIAL ACTIVITY OF SELECTIVE CYCLOOXYGENASE ANTAGONIST
... selected selective cyclooxygenase-2 ...of selective COX-2 (meloxicam,celecoxib,valdicoxib and ...conclusion selective cyclooxygenase (cox-2) inhibitor ...
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Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
... the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global cerebral ischemia in ...that cyclooxygenase-2 ...
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Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients
... non selective NSAID and onset of symptoms ...non selective NSAID hypersensitivity may consequently lead to a lower estimate of the percentage of COX-2 inhibitor ...
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The role of cyclooxygenase inhibitors in lipopolysaccharide induced hypophagia in chicken
... that cyclooxygenase 1 (COX) enzyme has an important role in lipopoly- saccharide (LPS)-induced hypophagia in mammals but the effect of COX on LPS-induced hypophagia has not been studied in avian ...
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Reduced Risk of Human Lung Cancer by Selective Cyclooxygenase 2 (Cox-2) Blockade: Results of a Case Control Study
... of selective cyclooxygenase-2 (COX-2) blocking agents and lung ...of 2:1 to the cases by age, gender, and county of ...of selective COX-2 inhibitors (primarily celecoxib ...
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Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase 2
... Because there is circumstantial evidence linking COX-2 ex- pression to intestinal tumorigenesis, we set out to test the hy- pothesis that COX-2 is involved directly in intestinal tumor de- velopment. In ...
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Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
... cortex 24 h after stroke and diminished infarct size by 48 % with respect to vehicle-treated animals after 3 days of reperfusion. Furthermore, nimesulide significantly attenuated the blood-brain barrier (BBB) damage and ...
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Cyclooxygenase 2 inhibitor celecoxib attenuates joint contracture following immobilization in rat knees
... Representative images of the posterior capsule of the knee joint in HE sections are shown in Fig. 5a-f. In the control group, the joint capsule was thin and densely stained. Infiltrated cells were scarcely seen ...
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Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells
... supplemented with mixed T3s (20.2% a-T3, 4.0% b-T3, 16.1% c-T3, 9.9% d-T3, 14.8% a-tocopherol, and 3.1% c-tocopherol), d-, c-, and a-CEHCs and CMBHCs, as well as some new metabolites, were observed in HPLC chro- ...
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Activation of Guanylate Cyclase-C With Heat-Stable Enterotoxin Fails to Potentiate Celecoxib-Induced Reduction in Colorectal Cancer Cell Growth in Vitro
... adenomatous polyps. In fact, a significant reason for the withdrawal of rofecoxib was that an increase in cardiovascular risks was observed during a study that was assessing the drug’s ability to prevent polyps (Zarghi ...
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Use of Propolis in Cancer Research
... Pérez et al. [52 evaluated the total antioxidant activity (TAA) of ethanolic extracts of propolis produced by Tetragonisca angustula from Mérida, Venezuela, through the radical cation ABTS. The TAA value was 190.6 ± 4.7 ...
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What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox 2 selective and non selective NSAIDs
... 'Everything is poison, there is poison in everything. Only the dose makes a thing not a poison.' Paracelsus might have been intrigued by the controversy that has arisen over the cardiovas- cular adverse effects that have ...
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The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression
... protease inhibitor cocktail [Roche, Indianapolis, IN], and 1× phosphatase inhibitor cocktail I/II [Calbiochem, San Diego, CA]) and incubated for 30 min on ...
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Calcium Antagonistic Activity of Biophytum Petersianum on Vascular Smooth Muscles of Wistar Rat
... Fig. 2. Effect of noradrenaline (1 µM) on rat thoracic aorta in Ca 2+ -free, high K + (60 mM) solution in absence (control) and presence of hydro-alcoholic extract of ...
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Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids
... and gefitinib (Gefi; 5 µM) with or without celecoxib (cele; 21.8 µmol/l), the samples were collected. samples incubated with only celecoxib were obtained 48 hours after celecoxib administration. (A–C) immunoblots ...
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