Selective cytotoxicity
Selective cytotoxicity of a Vietnamese traditional formula, Nam Dia long, against MCF 7 cells by synergistic effects
... The cytotoxicity of flavonoids on breast cancer cells, such as MCF-7 cells, is closely related to the expres- sion of estrogen receptors ...to selective cytotoxicity toward MCF-7 cells ...
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<p>Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway</p>
... K562/MDR cells, suggesting that myristoyl-CM4 showed selective cytotoxicity against K562/MDR and Jurkat cells. Further investigations showed that the binding activity of myristoyl-CM4 to HEK293 cells was ...
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Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells
... detection limits (0.5 mM) or that lithium was included within the polymer pockets, resulting in it being inaccessible to the electrode. The second method detected lithium at 8.5 µ g/L (1.21 µ M) after the sample was ...
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The novel compound STK405759 is a microtubule-targeting agent with potent and selective cytotoxicity against multiple myeloma in vitro and in vivo
... STK405759 prevented tubulin polymerization in a cell-free system and in viable MM cells. MTAs have been suggested as potential MM drugs [19–26]. However, the use of plaquitaxel and docetaxel was shown to be ineffective ...
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Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
... exhibited cytotoxicity toward both tumor and normal cell lines (Figure ...60% cytotoxicity toward the L-929 cells. However, the cytotoxicity of AgNPs and the extract against MCF-7 tumor cell line ...
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Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells
... In conclusion, the results obtained in present study indicate that PM produced by L. plantarum exhibited selective cytotoxic effect on various cancer cells in dose- and time-dependent manners without causing toxic ...
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Selective cytotoxicity of Pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds
... Following treatment, Jurkat cells were incubated with cell-permeable Hoechst 33342 dye; brightly stained condensed nuclei were considered to be apoptotic while non-bright, smooth nuclei[r] ...
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The future of cytotoxic therapy: selective cytotoxicity based on biology is the key
... induce selective tumor cytotoxicity, sparing normal tissues and therefore resulting in little toxicity, with their success being largely dependent on the magnitude of this speci- ...
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β‐Ketoiminato iridium(III) organometallic complexes: Selective cytotoxicity towards colorectal cancer cells HCT116 p53‐/‐
... selective for colorectal cancer, especially immortalized colorectal cancers with null p53 function. As the p53 plays a role in apoptosis, and the increased activity of these compounds against null-p53 cells gives ...
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<p>Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics</p>
... To evaluate the level of VP-loaded micelle and free VP uptake in GBM1A, JHGBM612, and NHA, fl ow cytometry was performed given the fl uorescence property of VP. Cells were incubated with VP at equivalent concentrations ...
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Selective Cytotoxicity and Apoptogenic Activity of Hibiscus Sabdariffa Aqueous Extract Against MCF 7 Human Breast Cancer Cell Line
... Aqueous extract of Hibiscus sabdariffa appeared to be toxic towards MCF-7 cells in a dose- and time-dependent manner. Each concentration was assayed in eight wells on each plate, and the average was considered as a ...
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Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non selective cytotoxicity and P glycoprotein inhibition
... The crude extract and aqueous alkaloid-enriched frac- tion displayed prominent P-gp inhibitory activity, which could be ascribed to the presence of solamargine, how- ever, other phytochemcials cannot be excluded. The P- ...
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Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles
... Diselenide-containing paclitaxel nanoparticles (SePTX NPs) indicated selectivity of cytotoxicity between cancerous and normal cells in our previous work. Herein, the mechanism is revealed by molecular biology in ...
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Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
... the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 µM) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast ...of ...
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Induction of selective cytotoxicity and apoptosis in human T4 lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest
... the cytotoxicity of this compound towards primary human blood lymphocytes. Briefly, blood was collected into a cell preparation tube containing sodium citrate (BD Vacutainer W , New Jersey, USA). After collection, ...
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Synthesis, Characterization, and Study of In Vitro Cytotoxicity of ZnO Fe3O4 Magnetic Composite Nanoparticles in Human Breast Cancer Cell Line (MDA MB 231) and Mouse Fibroblast (NIH 3T3)
... in cytotoxicity imparted by MCPs is the synergy of selective cytotoxicity of ZnO nanoparticles via reactive oxygen species (ROS) and exhausting scavenging activity of cancerous cells, which further ...
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The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
... induces selective cytotoxicity in primary chronic lymphocytic leukemia (CLL) cells when compared with healthy lymphocytes and tumor cells from other B-lymphoid malignancies, with a slight bias for CLL cases ...
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In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside
... has selective activity against malignant transformed ...moderate selective anticancer activity and prolong survival of cancer ...the selective cytotoxicity of AzGalp against malignant cells ...
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Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways
... Salvianolic acid A reverses cisplatin resistance in lung cancer A549 cells by targeting c-met and attenuating Akt/mTOR pathway.. Salvianolic acid A shows selective cytotoxicity agains[r] ...
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The aromatic head group of spider toxin polyamines influences toxicity to cancer cells
... relatively selective cytotoxicity activity against specific cancer cell lines and that the aromatic head group appears to be involved in conferring ...
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