Sequencing of the CIP29 mutant cell lines
Generation and Sequencing of Pulmonary Carcinoid Tumor Cell Lines
... only cell line to form xenograft tumors in nude ...derived cell line to generate libraries for next generation ...derived cell line is shown in Tables 2 and ...derived cell line ...the ...
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Whole genome sequencing of nine esophageal adenocarcinoma cell lines
... This is an adequate platform to present these data and the fact that the authors make all raw BAM files easily accessible to the community means that this study is particularly valuable to colleagues looking to contrast ...
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Constitutive production of alpha and beta interferons in mutant human cell lines.
... this cell line in antibodies to IFN-P did result in a substantial reduction in the constitutive expression of 6-16 mRNA (Fig. 3a), indicating that Cl cells produce levels of IFN-1 that a[r] ...
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Mutant p53 melanoma cell lines respond differently to CP induced apoptosis
... CP-31398 treatment resulted in a significant increase in the level of active conformation of p53 protein in M M R U and MeWo cells (Fig. In contrary, PAb-1620 antibody did not show an[r] ...
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Functional expression of native and mutant Y1 receptors in stably transfected adenocarcinoma cell lines
... Yi(C337S) mutant in C lY lC -3 epithelia is much reduced compared to C lY l -6 Yi ...and mutant receptor clones provides evidence that overall desensitisation pathways are ...
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Transcriptional Regulation of the BCL-6 Gene: Mechanistic Dissection Using Mutant Cell Lines
... the mutant cell line, but only barely detected in its parental cell line, ...the cell lines, these mutations do not have sig- nificant effects on the expression of the downstream ...
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Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines
... For this study, we focused our analysis on a collection of breast cancer samples with BRCA1 mutations. Tumors of this type may possess a distinctive, possibly unique, expression signature, despite their resemblance to ...
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Genotypic Stability, Segregation and Selection in Heteroplasmic Human Cell Lines Containing np 3243 Mutant mtDNA
... Cell lines containing various different proportions of mutant mtDNA remained generally at a consistent, average heteroplasmy value over at least 30 wk of culture in nonselective media and exhibited ...
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Potential of Sweet Potato Mutant Lines for Bioethanol Production
... irradiating cell suspension cultures with gamma rays ...the mutant lines from Sari variety of sweet potato which having higher production, starch content and potential to produce ...
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A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments.
... T cell activation allowed us to test PDL-1 expression as a putative mechanism of resis- tance in a significant number of KRAS mutant cell lines relatively rapidly and ...tumour cell ...
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Comprehensive High-Throughput RNA Sequencing Analysis Reveals Contamination of Multiple Nasopharyngeal Carcinoma Cell Lines with HeLa Cell Genomes
... RNA sequencing (RNA-seq) analysis pipeline, RNA CoMPASS, to investigate the presence of ectopic organisms within a number of NPC cell lines commonly used by NPC and Epstein-Barr virus (EBV) ...
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Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
... gene sequencing 103 candidate genes were selected for resequencing based on their involvement in pathways for drug metabolism, transport, or drug action for 5 classes of chemotherapy drugs tested in the in vitro ...
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Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing
... multiple cell types ( Raposo & Stoorvogel, 2013 ...same cell type are heterogeneous and can be classified into at least three classes based on their mode of biogenesis: (1) exosomes (30–130 nm in ...
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Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib
... To evaluate the antiproliferative effects of paclitaxel and gefitinib treatment, we performed a series of MTT cell growth assays. Treatment with gefitinib alone for 72 h resulted in a dose-dependent inhibition of ...
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High-Throughput RNA Sequencing-Based Virome Analysis of 50 Lymphoma Cell Lines from the Cancer Cell Line Encyclopedia Project
... RNA sequencing data from 50 common lymphoma cell culture models from the Cancer Cell Line Ency- clopedia project, we performed an unbiased global interrogation for the presence of a panel of 740 ...
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Cyclophilin A-Dependent Restriction to Capsid N121K Mutant Human Immunodeficiency Virus Type 1 in a Broad Range of Cell Lines
... CA mutant has a dif- ferent sensitivity for it. Thus, the N121K CA mutant could be a useful tool for analyzing the mechanism(s) underlying CypA-de- pendent restriction of HIV-1 ...
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Gefitinib induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
... What Do These Findings Mean? These findings (and those reported by Gong et al. and Costa et al.) indicate that activation of the proapoptotic BH3-only protein BIM is essential for gefitinib-induced killing of NSCLC cells ...
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Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines
... chondrosarcoma cell line panel including five IDH1/2 wildtype, three endogenous IDH1 mutant and two endogenous IDH2 mutant cell lines, originating from conventional central as well as ...
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EGFR-Mediated Reactivation of MAPK Signaling Induces Acquired Resistance to GSK2118436 in BRAF V600E-Mutant NSCLC Cell Lines
... Inhibition of EGFR signaling potentiates the antitumor activity of GSK2118436 in GSR xenograft models To further examine whether combined BRAF and EGFR inhibition can overcome acquired resistance to GSK2118436 in vivo, ...
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Identification of an env defective HIV 1 mutant capable of spontaneous reversion to a wild type phenotype in certain T cell lines
... in cell-free and cell-associated viruses to cause infection and to revert to wild-type was measured using several T cell ...of cell growth and ...T cell lines or when cells were ...
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