Serum amyloid P component
Influenza Virus Infection is not Affected by Serum Amyloid P Component
... Serum amyloid P component (SAP), a normal plasma protein of the pentraxin family (1), binds specifically to amyloid fibrils, to certain anionic gly- cans, to DNA, chromatin and ...
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Original Article Serum amyloid P component regulated the development of diabetic nephropathy via down regulation of CCL-1
... The development of kidney disease is a com- plex process involving a series of physiological changes, including cell proliferation, apoptosis, cell invasion, and metastasis. Clinical symp- toms of renal cell carcinoma ...
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Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages
... PON1: serum paraoxonase1; PPAR-γ: Peroxisome proliferator-activated receptor gamma; Psrc1: proline/serine-rich coiled-coil protein 1; RCT: Reverse cholesterol transport; RNA-seq: RNA sequencing; SAP: Serum ...
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Metabolic studies of radioiodinated serum amyloid P component in normal subjects and patients with systemic amyloidosis
... 125I-Serum amyloid P component (SAP), injected intravenously into 10 normal subjects, remained predominantly intravascular with mean (SD) T1/2 (half time) in plasma of ...
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The pentraxins, C reactive protein and serum amyloid P component, are cleared and catabolized by hepatocytes in vivo
... and serum amyloid P component (SAP), a universal constituent of amyloid deposits, were sought using the ligand 125I-tyramine cellobiose (TC) which is substantially retained within the ...
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Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines
... protein serum amyloid P component (SAP) (also called PTX2) to Candida al- bicans dampens the innate immune response to this ...surface amyloid-like structures important for adhesion and ...
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Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum
... whole serum samples, eluted from gel filtra- tion columns clearly ahead of ...man serum, SAP sedimented as single pentamers not complexed with any macromolecular ligand, regard- less of the presence or ...
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Selected expression profiling of full-length proteins and their variants in human plasma
... With increased interest in clinical pro- teomics—the comparative investigation of dif- ferential protein expression patterns for use in the diagnostic and prognostic assessment of disease states—the demand for techniques ...
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Verification of foetal Down syndrome biomarker proteins in maternal plasma and applications in prenatal screening for Down syndrome
... promote amyloid deposition β that causes age spots and excessive phosphorylated tau protein that forms tangles in nerve cells, while neurons inhibit glial cell hyper- plasia ...with amyloid pla- ques, which ...
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... protein, Serum amyloid A, Serum amyloid P component, Complement factors, Mannan-binding lectin, Fibrinogen, prothrombin, factor VIII, Von Willebrand factor, Plasminogen, Alpha ...
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In vitro interaction of soluble and amyloid form of serum amyloid a protein to bc3h1cells
... of Serum Amyloid A (SAA) and Serum Amyloid A protofibrils with BC3H1 cells of the mouse are dealt with in detail to study the binding of SAA protofibrils in various ...of Serum ...
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Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry
... APCS: Amyloid P component; APOC1: Apolipoprotein C1; C4BP: C4b-binding protein; CASPAR: Classification and diagnostic criteria for psoriatic arthritis; CD5L: CD5-like protein; CRP: C-reactive ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... We wanted to investigate whether stimulation with the most common human ApoE isoform, ApoE ε3, would induce human TREM2 signaling. For this, reporter cells were generated with TREM2-CD8-CD3 ζ and NFAT/lacZ constructs. ...
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... Alzheimer’s disease (AD) is the most common form of dementia. The major risk factor for AD is age. Between age 65-90 the risk for AD doubles every 5 years [1]. In 2010, AD cost the American economy $179 billion to care ...
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The Amino Acid Sequence of a Major Nonimmunoglobulin Component of Some Amyloid Fibrils
... constitutes up to 50% of amyloid fibrils from a patient with familial Mediterranean fever has been obtained. Partial amino acid sequences of three other proteins from patients with secondary amyloidosis were ...
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Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
... response [13]. However, extrahepatic production of SAA has been implicated as being more relevant to the patho- genesis of chronic inflammatory diseases including AD [13]. In mice, SAA is encoded by a family of three ...
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Serum Amyloid A: EVIDENCE FOR ITS ORIGIN IN POLYMORPHONUCLEAR LEUKOCYTES
... the amyloid A content of the culture medium and of sonicated, 2 × 10 6 cells was determined by ...of amyloid A-related material in the sonicated granulocytes compared with the individuals' serum ...
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Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
... Serum levels of the acute phase proteins SAA and CRP are known risk factors for cardiovascular disease in prospective studies [13, 42]. Conditions that induce acute phase response are in general associated with ...
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Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein
... and amyloid-beta fibrils [37, ...the amyloid fibrils (λ = 846 nm) and a narrower distribution of the fibril contour length ...of amyloid aggregates is not straightforward and may result in ...
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Plasma clearance kinetics of the amyloid related high density lipoprotein apoprotein, serum amyloid protein (apoSAA), in the mouse Evidence for rapid apoSAA clearance
... The plasma clearance kinetics of the amyloid-related high density lipoprotein HDL apoprotein serum amyloid protein apoSAA was examined in BALB/c mice by two different methods, using labe[r] ...
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