Serum sclerostin
Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
... of serum sclerostin or FGF-23 with bone turnover markers, calciotropic hormones, and biochemical ...FGF-23, sclerostin, iPTH, 25(OH) 2 D, calcium, phosphorus, ALP, uric acid, creatinine, bone ...
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Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass
... higher sclerostin levels in females than in males; in addition, sclerostin con- centrations were higher in males participating in weight- bearing disciplines than in those who participated in non- ...
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Original Article Serum sclerostin as an independent marker of peripheral artery disease in elderly persons
... and sclerostin). Left or right ABI val- ues that correlated with serum sclerostin levels in subjects were evaluated using univariate lin- ear regression ...
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Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study
... between serum scleros- tin levels and each clinical ...dian serum sclerostin levels because the normal serum sclerostin range in the PD population remains ...of sclerostin levels ...
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Association Between Serum Sclerostin Level and Carotid Artery Atherosclerosis in Hemodialysis Patients
... the serum sclerostin level increases in CKD patients especially ...that sclerostin was found in atherosclerotic plaques and that osteoblastic transition of VSMCs resulting in increased expression of ...
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Serum sclerostin in high activity adult patients with juvenile idiopathic arthritis
... of sclerostin occurs during mechanical loading of the skeleton ...[38,39]. Sclerostin is not a specific product of osteo- cytes, however ...[40]. Sclerostin is also produced by chondrocytes and ...
10
Serum sclerostin is an independent predictor of mortality in hemodialysis patients
... Our study has important strengths, including its long follow-up and the evaluation of several demographic and also biochemical variables that certainly could influence the outcomes. Also, the competing risk analysis ...
7
High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein 3a signaling but is not linked with greater structural damage
... reported serum level of sclerostin to be significantly lower in 46 AS pa- tients with mean disease duration (SD) of ...of sclerostin over 2-year follow-up was sig- nificantly higher in patients with ...
5
Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus
... Male ZDF rats (ZDF-Lepr fa ) and Zucker lean rats (ZDF-Crl) (n = 6/group) were purchased from Charles River laboratories (Margate, UK) at 8 weeks of age. Rats were acclimatised to their housing (21 °C ± 1 °C; 12 h ...
12
Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study
... fetuin-A serum measurements reveal mean- ingful differences depending on analytical procedures [28] and that previous data from our group indicating a link between fetuin-A in serum and the magnitude of VC ...
10
Role of sclerostin in the pathogenesis of chronic kidney disease-mineral bone disorder
... of sclerostin in the serum due to a decline in glomerular filtration rate (GFR) and/or increased sclerostin production by ...increased serum sclerostin levels in CKD ...of ...
8
Sclerostin: Intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders
... of sclerostin, bone formation inhibitor, but also the source of receptor activator of NF-kB ligand (RANKL), an essential cytokine responsible for osteo- clast activation and bone resorption in postmenopausal ...
9
Survey of the Status of Iron and Sclerostin in Major Thalassemia Patients
... of serum sclerostin (p=0.01). Sclerostin and ferritin showed association in the control group ...between sclerostin and hematocrit (p=0.05) as well as sclerostin and hemoglobin ...
6
Review Article The potential role of sclerostin in the development of osteoarthritis
... of serum sclerostin lev- els and monoclonal antibodies to sclerostin have advanced to phase II clinical trials or ...of sclerostin in the pathogenesis of OA and the potential utility of ...
9
Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults
... that serum sclerostin concentrations increased in participants in the resistance exercise group and walking group compared to its base level ...that sclerostin concentrations increased after acute ...
8
Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice
... that serum sclerostin levels were higher in Enpp1 −/− mice and that sclerostin mRNA expression was strongly increased in Enpp1 −/− osteocyte-like cells and mature, bone forming ...regulates ...
9
Sclerostin : a key regulator of bone metabolism
... disease. Sclerostin could be detected in the serum in all but one patients [mean ...p<0.001). Serum procollagen type 1 amino- terminal propeptide (P1NP) levels were also significantly higher in ...
188
Efficacy of anti sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia
... In conclusion, short-term treatment with the fully human anti-sclerostin monoclonal antibody BPS804 increased ALP and BSAP enzymatic activity in ALPL-deficient adult HPP patients. BPS804 administration increased ...
12
Association of Sclerostin with Bone Metabolism and Bone Mineral Density in Adults with Type 1 Diabetes Mellitus
... between sclerostin and iPTH is ...between sclerostin and iPTH in T2DM patients [15], whereas studies with T1DM have shown no association ...between sclerostin and iPTH in accordance with bone ...
7
Circulating levels of Dickkopf 1, Osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole body bone mineral density in older adults
... COULSON, J, BAGLEY, L, BARNOUIN, Y, BRADBURN, S, BUTLER-BROWNE, G, GAPEYEVA, H, HOGREL, J-Y, MADEN-WILKINSON, Tom, MAIER, A B, MESKERS, C, MURGATROYD, C, NARICI, M, PAASUKE, M, SASSANO, L, SIPILA, S, SHANTI, A L, ...
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