SH-SY5Y cells
<p>Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage</p>
... reverse BUP-induced oxidative damage in SH-SY5Y cells. However, when 3-MA was present, the level of total GS, SOD and MDA returned to the level of the BUP group. All these reports con fi rm our fi ...
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Differentiated Human SH-SY5Y Cells Provide a Reductionist Model of Herpes Simplex Virus 1 Neurotropism
... Neuronal SH-SY5Y cells release less extracellular virus during lytic HSV-1 ...differentiated SH-SY5Y neuronal cells (blue), undifferentiated SH-SY5Y cells ...
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Effect of long-term exposure of SH-SY5Y cells to morphine: a whole cell proteomic analysis
... neuroblastoma SH-SY5Y clone that stably overexpresses the μ -opioid (MOP) ...Wild-type SH-SY5Y cells express low levels of MOP receptor, and even lower (3- to 4-fold) levels of delta ...
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Original Article Baicalin protects against thrombin induced cell injury in SH-SY5Y cells
... control cells, cell viability was significantly decreased in SH-SY5Y cells treat- ed with ...with cells treated thrombin Figure ...viable cells in the lower-left quadrant (low PI ...
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Human ischaemic cascade studies using SH SY5Y cells: a systematic review and meta analysis
... the cells were manipulated prior to ex- ...the cells, for example, see Boltze and colleagues ...the SH-SY5Y cells were differentiated (19 comparisons), undifferentiated (8 comparisons) ...
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Wnt3a protects SH SY5Y cells against 6 hydroxydopamine toxicity by restoration of mitochondria function
... on SH-SY5Y ...6-OHDA. Cells pre-treated with Wnt3a-CM were partially protected against 6-OHDA ...when cells were pre-treated with Wnt3a-CM the reduction of cell viability was ...
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MiR 212 Attenuates MPP+ Induced Neuronal Damage by Targeting KLF4 in SH SY5Y Cells
... 3B). Nevertheless, no difference was found in the luciferase ac- tivities of KLF4-Mu reporter following a change of miR-212 ex- pression (Fig. 3B). Furthermore, miR-212 mimics or anti-miR-212 were transfected into ...
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Coffee Modulates the Function of Brain Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH SY5Y Cells
... Recent epidemiological studies showed that daily coffee consumption is associated with a lower risk for several neurological disorders such as Alzheimer’s disease and Parkinson’s disease; how- ever, the molecular ...
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Original Article The expression of the nicotinic acetylcholine receptor α3 subunit in the brains of patients with Alzheimer’s disease and its effects on α- and γ-secretases and Notch signal transduction in SH-SY5Y cells
... progenitor cells with DAPT (N-[N-(3,5-difluorophenacetyl)- L-alanyl]-S-phenylglycine t-butyl ester), a γ-sec- retase inhibitor, induces the inhibition of the Notch pathway and leads to reduced prolifera- tion and ...
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Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... in SH- SY5Y cells by western ...of cells with TBHP alone caused a significant decrease in Bcl-2/Bax level as compared with control ...of cells with MDHB (2, 4, 8 μM) could up-regulate ...
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Original Article Lentivirus-mediated silencing of HSP70 aggravated hypoxia-induced apoptosis in SH-SY5Y cells
... protected cells against hypoxic-induced ...in SH-SY5Y cells and elucidated the possible mechanisms underlying this ...in SH-SY5Y cells sig- nificantly decreased the cell ...
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Neuroprotective Mechanisms of Orientin against Hydrogen Peroxide-induced Oxidative Damage in SH-SY5Y Cells
... within SH-SY5Y cells ...neuronal cells have been determined to be the causes of ND, which provide an avenue to combat ND prior to the event itself by means of plant derivatives such as ...
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Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH SY5Y cells
... neuroblastoma SH-SY5Y cell line upon persistent ER ...seeding, SH-SY5Y cells were serum starved for 8 h and treated with 0 or 100 nM of thapsigargin for 16 h, in the presence or absence ...
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In vitro neuroprotective effect of charantin from Momordica charantia against neurotoxin and endoplasmic reticulum stress-induced cell death in SH-SY5Y cells
... lines SH-SY5Y were utilized in this study to prove the effectiveness of charantin on the against neurotoxin and endoplasmic reticulum (ER) stress-induced cell ...in SH-SY5Y neuroblastoma cell ...
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Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism
... SH-SY5Y cells were pretreated with different concentra- tions of baicalein for 1 hour and then co-treated with rote- none (20 μ M) for another 6 hours in serum-free ...
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Mechanistic basis for protection of differentiated SH SY5Y cells by oryzanol rich fraction against hydrogen peroxide induced neurotoxicity
... in SH-SY5Y cells leading to acti- vation of ERK1/2 gene as a protective ...In SH-SY5Y cells, Akt activation is linked to inhib- ition of apoptosis especially in the presence of ...
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Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity
... P19 cells at the concentration of 1 mM, but not in the PC12 or SH-SY5Y ...to SH-SY5Y cells in the beginning of the differentiation process for 3–6 days greatly reduced cell ...
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
... [27–30]. SH-SY5Y cells have been useful as a human neuronal cell model in the study of neurodegeneration ...using SH-SY5Y cells, we have recently revealed TRPM2 channel ...
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Original Article Parthanatos is involved in bupivacaine induced injury in SH-SY5Y cells
... The SH-SY5Y cells, exposed to 5 mM of bupiva- caine for 2 hr, were washed with ice-cold PBS, left on ice for 10 minutes, and then re-sus- pended inisotonic homogenization buffer [250 mM sucrose, 10 ...
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Optimising parameters for the differentiation of SH SY5Y cells to study cell adhesion and cell migration
... (a)). Cells were counted from each condition and the number of differentiated cells was expressed as a percentage of the total cells counted (Figure 3 ...onal cells involves arrest of ...
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