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Signaling Pathways

Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury

Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury

... many signaling pathways are altered as a consequence of gene expres- sion ...NF-κB signaling pathway played an important role in rhabdomyolysis- induced ...

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Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection

Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection

... GFR signaling (19–22), and MuPyV-ganglioside interactions could mediate MuPyV activation of GFRs and downstream sig- ...of signaling pathways in the presence or absence of GD1a, a known MuPyV ...

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Linearity in Cell Signaling Pathways

Linearity in Cell Signaling Pathways

... Here, we show how linearity can facilitate reliable fold-change output in the face of parameter variations. For a linear input-output response, parameter variation affects only the gain of the response. In turn, ...

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Stress Signaling Pathways for the Pathogenicity of Cryptococcus

Stress Signaling Pathways for the Pathogenicity of Cryptococcus

... stress signaling cascades, it remains unclear how pathway cross talk is coordinated in response to incoming ...Mpk1 pathways, their cross talk points are not ...core signaling components in many ...

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Exercise for the heart: signaling pathways

Exercise for the heart: signaling pathways

... several signaling pathways, in particular, the growth factor neuregulin1 (NRG1)-ErbB4-C/EBPβ and insulin-like growth factor (IGF)-1-PI3k-Akt signaling ...

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Endometrial Carcinogenesis and Molecular Signaling Pathways

Endometrial Carcinogenesis and Molecular Signaling Pathways

... WNT signaling pathways are less understood, and they work in a β -catenin independent manner, such as WNT/Cal- cium pathway, in which the WNT binds to Frizzled receptors, resulting in the release of calcium ...

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Endothelial activation: intracellular signaling pathways

Endothelial activation: intracellular signaling pathways

... of signaling pathways through which TNF could acti- vate NF- κ B and ...[19]. Signaling is initi- ated when ligand-occupied receptors recruit the binding of intracellular adaptor proteins to the ...

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Signaling pathways in the development of infantile hemangioma

Signaling pathways in the development of infantile hemangioma

... individual signaling pathways in ...tiple pathways often control a common process. Second, many signaling outcomes impact other processes through feedback loops and compensatory ...molecular ...

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Communication codes in developmental signaling pathways

Communication codes in developmental signaling pathways

... Many signaling pathways share a convergent structure, with ligands interacting with receptors in a many-to-many fashion and information ‘ funneling ’ down to control a smaller number of intracellular ...RTK ...

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Over-expression of CKS1B activates both MEK/ERK and JAK/ STAT3 signaling pathways and promotes myeloma cell drug- resistance

Over-expression of CKS1B activates both MEK/ERK and JAK/ STAT3 signaling pathways and promotes myeloma cell drug- resistance

... Fig. 3. CKS1B-over-expression activates STAT3 and MEK/ERK signaling pathways. CKS1B was knocked down in KMS28PE, OCI-MY5 and XG-1 cells. Cells were cultured for 72 hours and cell lysates were prepared. (A) ...

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Retinoic acid signaling pathways

Retinoic acid signaling pathways

... Although many advances have been made in understanding RA signaling, a reproducibility crisis for RA signaling is evident (Duester, 2017). Several previously proposed functions for RA are not supported by ...

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Cotargeting survival signaling pathways in cancer

Cotargeting survival signaling pathways in cancer

... Carracedo et al. examine the relationship between these pathways in prostate and breast cancer cell model systems (see the related articles beginning on pages 3051 and 3065, respectively). Their findings suggest a ...

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Clinical significance of mitofusin 2 and its signaling pathways in hepatocellular carcinoma

Clinical significance of mitofusin 2 and its signaling pathways in hepatocellular carcinoma

... Mitofusin 2 was first recognized as a key protein not only regulating mitochondria fusion but also participat- ing in tumor cell proliferation. Although MFN2 has not been proven to act as a tumor suppressor gene in can- ...

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CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

... tumor-suppressor pathways is frequently observed in glioma ...Rb1 signaling pathways, respectively ...oncogenic pathways are more frequently disrupted in high-grade glioma cells ...

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The Aspergillus fumigatus Mucin MsbA Regulates the Cell Wall Integrity Pathway and Controls Recognition of the Fungus by the Immune System

The Aspergillus fumigatus Mucin MsbA Regulates the Cell Wall Integrity Pathway and Controls Recognition of the Fungus by the Immune System

... cell signaling and cell wall plasticity are crucial for maintaining physiologic ...important signaling mucin responsible for activation of a variety of mitogen-activated protein kinase (MAPK)-dependent ...

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An integrated analysis of key microRNAs, regulatory pathways and clinical relevance in bladder cancer

An integrated analysis of key microRNAs, regulatory pathways and clinical relevance in bladder cancer

... functional enrichment analysis indicated that the significant DEGs in BC were related to classical cancer pathways such as cell cycle and MAPK signaling pathways. The key DEGs such as CDK1, CCNB1, ...

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A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders

A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders

... regulation-related pathways, such as long-term potentiation, long-term depression and neuroactive ligand-receptor interaction; It has been indicated that the adjunctive drugs WY and NX, and the messenger drug GC ...

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Impact of steroid hormone signals on Drosophila cell cycle during development

Impact of steroid hormone signals on Drosophila cell cycle during development

... the signaling pathways affecting these cell cycles are well characterised ...key signaling mole- cule in the morphogenesis of the wing is the Wingless (Wg) protein, a member of the Wnt family of ...

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Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential

Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential

... same signaling pathways have been repeatedly shown to be targets for various anoikis related miRNAs, such as the TGF-𝛽/Smad and PI3K/Akt pathways, thus emphasizing the need to focus on these ...

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mTor signaling is required for the formation of proliferating Müller glia derived progenitor cells in the chick retina

mTor signaling is required for the formation of proliferating Müller glia derived progenitor cells in the chick retina

... mTor signaling in the formation of Mu ̈ ller glia-derived progenitor cells (MGPCs) in the chick ...mTor signaling) is present in early-stage retinal progenitors, differentiating amacrine and ganglion cells, ...

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