Significant single nucleotide polymorphisms
Detecting significant single nucleotide polymorphisms in a rheumatoid arthritis study using random forests
... a single tree in ...and single-nucleotide polymorphism (SNP) data analyses ...no single SNP was significant, they achieved an appealing prediction performance with their top 500 SNPs ...
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Effect of population stratification on the identification of significant single nucleotide polymorphisms in genome wide association studies
... In the primary analyses of these data, a clustering algorithm in the program PLINK was used to reduce the VIF to 1.14, after which genomic control was used to control residual confounding. Here we use stratification ...
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Picking single nucleotide polymorphisms in forests
... In the second stage, consideration of all variables in the logReg model (Table 1) shows the largest genetic effects for SNPs on chromosomes 6, 11, and 18. Of these, the regions on chromosomes 6 and 18 correspond to the ...
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Single Nucleotide Polymorphisms and Linkage Disequilibrium in Sunflower
... was significant LD variability among loci, the slower decay in sunflower inbred lines can be attributed to population bottlenecks produced by in- breeding and artificial selection, a common phenome- non in ...
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Single nucleotide polymorphisms and disease gene mapping
... Although much is known about patterns of LD within the MHC, the important outstanding question for human genet- ics is whether the same pattern of LD exists elsewhere in the genome. The large, dense set of SNPs now ...
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Single nucleotide polymorphisms (SNPs) in occupational exposure assessment
... the significant associated SNPs with both skin NKAs and urine biomarkers, and the use of MLRMs including 10 SNPs with the lowest P-values provided one way to construct a final exposure model and investigate the ...
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Evidence for single nucleotide polymorphisms and their association with bipolar disorder
... ically significant, was conducted by Belmonte Mahon et al 83 on combined data from three GWASs: the NIMH Bipolar Disorder Genetic Association Information Network (GAIN- BP), NIMH BiGS, and a German sample, with a ...
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Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer
... We also carried out a meta-analysis in an effort to increase power to identify any SNPs with small effects. Published data are available for 11 ATR and 11 CHEK1 SNPs. There was no evidence for effects on breast cancer ...
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Single nucleotide polymorphisms of Kit gene in Chinese indigenous horses
... very significant role in transportation and war and used to be placed in the first position of six domestic animals (cattle, sheep, pig, dog, and chicken) in ancient ...
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Prioritizing single-nucleotide polymorphisms and variants associated with clinical mastitis
... a significant number of candidate SNPs/variants between the genes vitamin D-binding protein precursor (group-specific component) and neuropeptide FF receptor 2 genes on chro- mosome 6 in cow are known to be ...
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Studies on the relationship between single nucleotide polymorphisms and protein interactions
... not significant (p = ...obtain significant results that neutral polymorphism (pSNPs) would be found more often on the surface non-interface than in the interface ...
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Single Nucleotide Polymorphisms in HSP17.8 and Their Association with Agronomic Traits in Barley
... Nucleotide polymorphisms By using EcoTILLING, 13 polymorphic sites were detected in the targeted region of ...same nucleotide changes in sequence with only one exception that one sample showing two ...
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Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet’s Disease
... were significant differences be- tween the BD patients (n=220) and controls (n=217) concerning the frequencies of ...no significant difference between the AG genotype in two groups ...
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ABCB1 and ABCC1 single-nucleotide polymorphisms in patients treated with clozapine
... We analyzed the impact of common SNPs of ABC transporters (ABCB1 rs1045642 and ABCC1 rs212090) on important clinical outcomes in patients treated with CZ. Carriers of T (A) allele (ABCB1) and A allele (ABCC1), in ...
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Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults
... The Institutional Review Board of the University of California, Davis, approved the study, which was con- ducted according to Good Clinical Practice guidelines and the Declaration of Helsinki, version 1989. Written in- ...
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Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke?
... any significant associations between MI/CAD SNPs and stroke, the chromosomal regions harboring these loci might still contain stroke-related SNPs that are not in high LD with the MI-associated SNPs, as the example ...
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Ranking non-synonymous single nucleotide polymorphisms based on disease concepts
... no significant deviations in the reported performance measures and therefore conclude that the performances observed were not an artefact of our disease-specific weighting ...
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Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes
... less significant than originally ...of single nucleotide polymorphisms (SNPs) identified by GWAS has been used to develop sets of genetic markers able to more accurately stratify asthma ...
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Modeling Effects of Human Single Nucleotide Polymorphisms on Protein-Protein Interactions
... A highly conserved position within the protein sequence is often related to an important biological function. Multiple sequence alignment analysis showed that most of the posi- tions corresponding to interfacial nsSNPs ...
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Original Article Single nucleotide polymorphisms of HER2 related to osteosarcoma susceptibility
... In present study, 5 SNPs from HER2 were ana- lyzed and their functions were different. Two of them rs1136201 and rs1508808 have demon- strated that either genotypes or alleles are associated with the increased risk of ...
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