Simian Immunodeficiency Virus
Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
... is simian immunodeficiency virus (SIV), and the other is chimeric simian-human immunode- ficiency virus (SHIV), in which the envelope glycoproteins of SIV are replaced with those of ...
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Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery
... of simian immunodeficiency virus strain 239 deleted of V1-V2 sequences in the envelope gene (SIV239 ⌬ V1-V2) was used for vaccine/challenge experiments in rhesus ...
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Variability of Viral Load in Plasma of Rhesus Monkeys Inoculated with Simian Immunodeficiency Virus or Simian-Human Immunodeficiency Virus: Implications for Using Nonhuman Primate AIDS Models To Test Vaccines and Therapeutics
... with simian-human immunodeficiency virus ...or simian immunodeficiency virus mac 251 (SIVmac 251), we estimated variability in three viral load (VL) measures: peak VL, the ...
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Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus
... human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) gp120 exterior enve- lope glycoprotein to the initial receptor, CD4 (1, 2), triggers con- formational ...
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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... human immunodeficiency virus type 1 (HIV-1) epidemic arose by transmission of simian immunodeficiency virus (SIV) SIVcpz from a subspecies of common chimpanzees (Pan troglodytes ...
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A Quantitative Measurement of Antiviral Activity of Anti-Human Immunodeficiency Virus Type 1 Drugs against Simian Immunodeficiency Virus Infection: Dose-Response Curve Slope Strongly Influences Class-Specific Inhibitory Potential
... Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in ...
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
... of simian immunodeficiency virus (SIV) originally derived from naturally infected sooty mangabeys (23) causes an immunodeficiency syndrome which closely resembles AIDS in human immuno- ...
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Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
... human immunodeficiency virus type 1 (HIV-1) into target ...and simian immunodeficiency virus (SIV) employ the same chemokine receptors for ...CXCR4-tropic virus or with a ...
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Natural Infection of a Household Pet Red-Capped Mangabey (Cercocebus torquatus torquatus) with a New Simian Immunodeficiency Virus
... of simian immunodeficiency virus (SIV) isolates reveal that they belong to five distinct lineages of the lentivirus family of retroviruses ...lenti- virus lineages form a distinct subgroup, ...
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Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus
... of simian immunodeficiency virus (SIV) Env or Gag or a Rev-Tat-Nef fusion ...epitope. Virus-specific CD8 ⴙ T cell responses persisted at high levels up to the time of challenge at 18 weeks ...
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Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections
... human immunodeficiency virus (HIV) infection has largely been attributed to the rapid and severe depletion of CD4 ⴙ T cells in the gastrointestinal (GI) ...the simian immunodeficiency ...
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Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
... human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) virions with protein A-conjugated gold (PAG) nanoparticles using negative-stain electron ...
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Complex determinants of macrophage tropism in env of simian immunodeficiency virus.
... Characterization of infectious molecular clones of simian immunodeficiency virus SIVmac and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly c[r] ...
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Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication
... pathogenic simian immunodeficiency virus (SIV) mac239 clone has been well charac- ...human immunodeficiency virus type 2 (HIV-2)-infected ...
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Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys.
... Characterization of infectious molecular clones of simian immunodeficiency virus SIV mac and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly [r] ...
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Modification of a loop sequence between α helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV 1) derivative that has simian immunodeficiency virus (SIVmac239) vifand CA α helices 4 and 5 loop improves replication in cynomolgus monkey cells
... adapted virus has not yet been fully characterized; so it may be that fur- ther modifications of the viral genome are necessary for optimal replication of HIV-1 genomes in OWM ...incoming virus by its ...
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Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance
... ZIKV infection assessment in LN cells. Lymph node cells from day 5 and day 27 post-ZIKV infection were sorted into T cell, B cell, and macrophage populations (Fig. S2) for assessment of ZIKV viral RNA via qRT-PCR. RNA ...
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Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.
... binding is not necessary for macrophage infection as well. What, then, is the importance of UNG binding to Vpr? A recent study showed that in the presence of Vpr, the mutation rate of HIV in a single-round assay was ...
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A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation
... Viruses and animals. The 35 animals used for the bulk of the analyses were infected with SIVmac239 between 1998 and 2001. These animals were chal- lenged with SIV in trials of vaccine efficacy and pathogenesis (2, 21, ...
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Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop.
... Virus isolation. SIVsm isolation from one West African household pet manga- bey has been reported in detail elsewhere (41). Viruses were recovered from mangabey samples either by cocultivating monkey cells with ...
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