single agent
Analysis of a Single-Agent Search
... On the other hand, the pathology of a single-agent search has been much less investigated. It was first discovered in 2003 by Bulitko et al. [3], and it was first demonstrated on a synthetic, two-level ...
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Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells
... Salvianolic Acid B (Sal B), an active compound extracted from the Chinese herb Salvia miltiorrhiza, is attracting more and more attention due to its biological activities, including antioxidant, anticoagulant and ...
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Bevacizumab combined with chemotherapy vs single-agent therapy in recurrent glioblastoma: evidence from randomized controlled trials
... Results: We pooled 1,169 patient cases from seven RCTs. Bevacizumab combined with che- motherapy showed a significantly improved progression-free survival (PFS) (HR=0.65; 95% CI 0.57–0.74; P<0.001) compared to ...
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Characterizing the kinetics of lymphocytosis in patients with chronic lymphocytic leukemia treated with single-agent ibrutinib
... We analyzed two multicenter, randomized, open-label phase 3 trials of single-agent ibrutinib in patients with CLL. RESONATE-2 (NCT01722487) evaluated ibrutinib ver- sus chlorambucil in the first-line ...
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A Step toward Decision making in Diagnostic Applications using Single Agent Learning Algorithms
... A single action is not important; the policy is important that is the sequence of correct actions to reach the ...of single agent learning, Section III describes Q-learning algorithm, Sarsa learning ...
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In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia
... a single agent and not in combination with other chemotherapeutic agents in cell lines and primary blast cells from acute lymphoblastic leukemia based on the hypothesis that the intrinsic gen- omic ...
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In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma
... We evaluated the efficacy of afatinib in HNE-1 xenograft mouse model, both as a single agent and in combination with GEM. As shown in Figure 4A, afatinib modestly inhibited NPC tumor growth in the HNE-1 ...
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Comparison of single agent versus combined chemotherapy in previously treated patients with advanced urothelial carcinoma: a meta-analysis
... A total of 1,685 advanced UC patients from 50 cohorts are included for analysis. Based on our pooled results, we found that combined chemotherapy resulted in a statisti- cally increased ORR, DCR, and 1-year OS but not ...
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Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition
... the single-agent use of inhibitors of other DDR components, exemplified by the cytotoxicity of PARP inhibitors in HRR-defective tumours [8] is an exciting new paradigm in cancer that led to a rapid ...
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Efficacy and Risk Factors Associated to Resistance to Single Agent Chemotherapy in Low Risk Gestational Trophoblastic Neoplasia
... Extensive experience has been accumulated in treating low-risk GTN over time, and over 14 different types of chemotherapy regimens have been described, but no consensus has been reached about the preferred first-line ...
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First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer
... first-line single agent treatment with ...first-line single agent treat- ment with gefitinib may have better effect in patients with advanced NSCLC than standard first-line che- motherapy ...
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Incidence and management of adverse events in patients with relapsed and/or refractory multiple myeloma receiving single-agent carfilzomib
... 20. Nooka A, Badros A, Patel P, McCulloch L, Lonial S, Kaufman J. Hematologic safety data from four phase 2 studies of single-agent carfilzomib in relapsed and/or refractory multiple myeloma. Abstract ...
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Preclinical Efficacy of Nimotuzumab, an Anti Egfr Monoclonal Antibody as a Single Agent Therapy in Human GBM u87mg Xenografts
... different single therapies in nude mice bearing both subcutaneous and orthotopic brain xenografts of the U87MG human GBM cell ...chemotherapeutic agent temozolomide ...a single agent against ...
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Trastuzumab, an appropriate first line single agent therapy for HER2 overexpressing metastatic breast cancer
... first-line single agent in oligosymptomatic patients that fit the eligibility of the study by Vogel and colleagues and can be used as a platform onto which other molecular therapies, not neces- sarily ...
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The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN.
... Fig. 4. Evaluation of preclinical efficacy of PF- 06463922 in an orthotopic CLB-BAR xenograft neuroblastoma setting. 2×10 5 CLB-BAR cells were injected into the left adrenal gland of nude mice and adrenal tumor growth ...
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A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
... Dose-finding designs for phase I trials have been widely discussed over the past two decades. Many methods have been proposed to identify maximum tolerated dose (MTD) in single-agent dose-finding clinical ...
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Single-Agent Thalidomide for Treatment of Malignant Paraganglioma of the Organ of Zuckerkandl
... After discussion with the patient, he was started on single-agent thalidomide 200 mcg daily based on the lack of effective chemotherapy. The patient was followed closely with repeat imaging every 3 months. ...
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Tomotherapy concomitant with cetuximab, followed by cetuximab as single-agent therapy for unresectable squamous cell carcinoma of the skin: a case report
... Background: Cutaneous squamous cell carcinoma (SCC) is the second most frequency of all skin tumors. Incidence of SCC has risen significantly due to an increased sun exposure and the number of immunodeficient patients. ...
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Single Agent vs Multi Agent Techniques for Concurrent Reinforcement Learning of Negotiation Dialogue Policies
... multi- agent RL but only standard single-agent RL, in particular an on-policy Monte Carlo method (Sut- ton and Barto, ...But single-agent RL tech- niques are not well suited for ...
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Postoperative chemotherapy with single-agent fluoropyrimidines after resection of colorectal cancer liver metastases: a meta-analysis of randomised trials
... with single-agent fluoropyrimidines after resection of liver metastasis likely alters the natural course of the disease, because it does not affect ...
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