Single amino acid substitution
A Single Amino Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli
... ObgE*-mediated PCD is distinct from previously described bacterial cell death mechanisms. To unravel the mechanism underlying ObgE*-mediated PCD, we investigated the involve- ment of key regulators of previously ...
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A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction
... Iwamoto and co-workers (Iwamoto et al., 1999, 2000) and others studied the structure of dog NCX1 protein. On the topologi- cal disposition of N842 (corresponding to mouse N874), these authors concluded that it is ...
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A single-amino-acid substitution in polyomavirus VP1 correlates with plaque size and hemagglutination behavior.
... Thus, these data demonstrate that the major capsid protein VP1 determines the HA properties of the virus and that the determinant within VP1 is amino acid residue 92; glutamic acid conve[r] ...
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A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Resistance
... increased acid lability have been previously characterized (35); an FMDV variant with increased resistance to acid inactivation was also isolated (54), although the molecular basis for this phenotype was ...
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A Single-Amino-Acid Substitution in the TvbS1 Receptor Results in Decreased Susceptibility to Infection by Avian Sarcoma and Leukosis Virus Subgroups B and D and Resistance to Infection by Subgroup E In Vitro and In Vivo
... cidence was 100% in both lines, with similar tumor growth rates, depending on the initial dose of ASV (Fig. 4A, B, and C). Animals that received the 1,000-FFU dose were terminated due to tumor burden by day 18 and those ...
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A single amino acid substitution alter antigenicity of Glycosylated protein 4 of HP PRRSV
... the amino acids (aa) sequences of AR(s) is aligned among PRRSV strains for further identify the key aa site(s) impact the antigenicity of the ...specific amino acid in ...
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Adaptive evolution of fish hatching enzyme: one amino acid substitution results in differential salt dependency of the enzyme
... Naruse, 1996), although adult fish are occasionally found in brackish water (Miyamoto et al., 1986). The death rate of medaka embryos in brackish water and seawater is higher than that in freshwater (Inoue and Takei, ...
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Ebola Virus Transcription Activator VP30 Is a Zinc-Binding Protein
... that single- amino-acid substitutions within the zinc-binding domain of Sendai virus V protein led to the reduction of zinc-binding activity to between 22% and 68% of that of the wild type but not to ...
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Loss and Gain of Elicitor Function of Soybean Mosaic Virus G7 Provoking Rsv1-Mediated Lethal Systemic Hypersensitive Response Maps to P3
... a single dominant resistance gene in soybean PI 96983 (Rsv1), confers extreme resistance against all known American strains of Soybean mosaic virus (SMV), except G7 and ...four amino acid differences ...
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The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
... this substitution had an antigenic effect of ...other single amino acid substitution was respon- sible for a greater antigenic effect than D128T in the context of NL/B1/68 ...a ...
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Preparation and characterization of a site-directed mutant of Escherichia coli L-threonine dehydrogenase
... Our reaction a single amino acid substitution can whereby technique in better understanding the powerful The two is sequence of an enzyme amino acid without function mutagenesis threonin[r] ...
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A Conserved Tryptophan-Rich Motif in the Membrane-Proximal Region of the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Is Important for Env-Mediated Fusion and Virus Infectivity
... the single amino acid substitution W672P re- sulted in Env proteins which were up to twice as fusogenic as wild-type Env in a syncytium ...other single amino acid ...
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Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant
... the single amino acid substitution orthologous to the G119S mutation responsible for high level resistance to organophosphate and carbamate insecticides in mosquitoes can also generate high ...
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Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease
... caused single (or double) amino acid(s) ...a single amino acid substitution in clinical isolates were estimated based on the streptococcal pyrogenic exotoxin B (SpeB) ...
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Gelsolin related amyloidosis Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin
... Complete amino acid sequence analyses show that the two amyloid components obtained are fragments of gelsolin, an actin-modulating protein occurring in plasma and the ...a single amino ...
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Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.
... We show that a single amino acid substitution Arg to Gln or Lys at position 8 of the protease results in a substantial decrease in the inhibitory activity of the drug on the enzyme and a[r] ...
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Self-Compatible B Mutants in Coprinus With Altered Pheromone-Receptor Specificities
... a single amino acid substitution (R96H) at the intracellular end of transmembrane domain ...F67W substitution in this same pheromone enabled it to activate the normally incompatible ...
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A Single Amino Acid in the Adenovirus Type 37 Fiber Confers Binding to Human Conjunctival Cells
... precise amino acid sequences in the Ad fiber protein that mediate cell attachment have yet to be ...A single amino acid substitution in the Ad19p fiber distal do- main (knob), ...
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Substitution of a single amino acid residue is sufficient to allow the human amphotropic murine leukemia virus receptor to also function as a gibbon ape leukemia virus receptor.
... deduced amino acid sequences of the HaPiT2 and PiT2 proteins suggested that differences in the amino acid composition of the extracellular region(s) of the hamster and human proteins account ...
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Molecular basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch Nyhan syndrome
... the single aberrant tryptic peptide in HPRTKinston revealed an aspartic acid to asparagine amino acid substitution at position ...This amino acid substitution can ...
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