Sirolimus therapy
Long-term efficacy and safety of sirolimus therapy in patients with lymphangioleiomyomatosis
... Normally distributed data are reported as the mean ± SD; data that were not normally distributed are reported as the medians and interquartile ranges (median [25, 75%]). The normality of the data was analyzed by the ...
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Pneumocystis Jirovecii Pneumonia During Sirolimus Therapy for Kaposiform Hemangioendothelioma
... starting sirolimus therapy and near the end of his prednisolone taper (at age 4 months), he presented with fever, tachypnea, and ...A sirolimus trough level 5 days before admission was ...
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Rapid Regression of Left Ventricular Outflow Tract Rhabdomyoma After Sirolimus Therapy
... Oral sirolimus therapy resulted in a rapid regression of the tumor and al- leviation of out fl ow tract obstruction within 1 month of ...of sirolimus therapy in alleviating critical left ven- ...
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Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients
... SRL therapy warrants further attention in evaluating renal function ...non-sirolimus therapy would strength the causal relationship between SRL use and renal ...
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Sirolimus Therapy in Congenital Hyperinsulinism: A Successful Experience Beyond Infancy
... to sirolimus therapy, without major adverse effects during the fi rst year of ...of sirolimus in an infant with severe hyperinsulinemic hypoglycemia due to a compound heterozygous ABCC8 gene ...
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The impact of sirolimus therapy on lesion size, clinical symptoms, and quality of life of patients with lymphatic anomalies
... We reviewed 20 patients with LMs (five with cystic LM, three with KLA, three with GLA, six with GSD, and three with CCLA) who were treated with sirolimus at our insti- tution. Patient characteristics and treatment ...
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Severe Hyperinsulinemic Hypoglycemia in a Neonate: Response to Sirolimus Therapy
... Our decision to proceed with this treatment option was prompted by the lack of response to standard therapies, with the aim to avoid the major adverse effects of subtotal pancreatectomy. The desired glycemic control was ...
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Nanomedicines in renal transplant rejection – focus on sirolimus
... effects. Sirolimus slows the growth of established experimental tumors (Guba et al ...2004), sirolimus therapy oughtweighs other immunosuppressive agents in the low incidence of ...the ...
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A retrospective review of oral low-dose sirolimus (rapamycin) for the treatment of active uveitis
... of sirolimus in treating patients with severe uveitis is ...suggest sirolimus may be an effective agent for controlling uveitis, but its role was not clearly defined [Wroblewski KJ, Sen HN, Yeh S, it ...and ...
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Functional improvements in patients with lymphangioleiomyomatosis after sirolimus: an observational study
... started sirolimus therapy because of symptomatic chylothorax, and two of these patients were complicated with chylous ...olimus therapy. Before sirolimus therapy, all patients had ...
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Is sirolimus a therapeutic option for patients with progressive pulmonary lymphangioleiomyomatosis?
... despite sirolimus therapy for twelve months ...for sirolimus therapy ...to therapy may be a crucial factor contributing to outcome discrepancies ...of sirolimus may be the fact ...
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LFA 1–specific therapy prolongs allograft survival in rhesus macaques
... LFA-1/CD28 blockade prevents donor-specific antibody formation. To assess whether anti–LFA-1–treated animals developed donor-spe- cific antibodies (DSAs) after islet transplantation, we incubated recipient serum with ...
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Blue Rubber Bleb Nevus Syndrome: Successful Treatment With Sirolimus
... Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder with characteristic vascular malformations of the skin, gastrointestinal sys- tem, and, less often, other organ systems. The characteristic cutaneous lesions ...
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Efficacy and safety of low-dose Sirolimus in Lymphangioleiomyomatosis
... Because sirolimus has the potential to exacerbate pre-existing or newly occurring renal lesions by causing massive proteinuria, glomerulonephritis or thrombotic microangiopathy [25], patients with TSC who already ...
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Sirolimus Improves Pain in NF1 Patients With Severe Plexiform Neurofibromas
... with sirolimus to shrink growth of PNs, after a multidisciplinary staff reviewed their ...to sirolimus therapy was based retrospectively on a 1-year morphologic study of PN with 3- dimensional MRI ...
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In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus
... removed and replaced with fresh medium of serum-free fetal bovine. For the MTT assay and TUNEL assays, two equal RPE cell experimentation series were prepared and one series used for each test exclusively. The eight ...
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Late Thrombosis of Sirolimus-Eluting Stent: A Multifactorial Problem
... a sirolimus-eluting stent was implanted on the culprit left anterior descending coronary artery at primary percutaneous coronary intervention (PCI) for acute myocardial ...antiplatelet therapy with aspirin ...
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A Case of a Central Conducting Lymphatic Anomaly Responsive to Sirolimus
... lymphatic malformations involving bone and significant chylous effusions had substantially decreased pleural effusion output soon after initiation of treatment with chest tube removal. Other case reports also discuss ...
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Multifocal Lymphangioendotheliomatosis With Thrombocytopenia: Clinical Features and Response to Sirolimus
... At 4 days of age, the infant presented with gastrointestinal bleeding (melena); his hemoglobin level was 7.2 g/dL. Endoscopy revealed 2 mucosal vascular gastric lesions and 1 large vascular lesion in the cecum. From age ...
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Successful Treatment of Juvenile Polyposis of Infancy With Sirolimus
... survival, sirolimus and its analogs have an expanding role in the treatment of tumors associated with tuberous sclerosis complex, 12,13 lymphoproliferative disease, and autoimmune ...
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