SIV, simian immunodeficiency virus
Direct ex vivo simian immunodeficiency virus (SIV)-specific cytotoxic activity detected from small intestine intraepithelial lymphocytes of SIV-infected macaques at an advanced stage of infection.
... Human immunodeficiency virus (HIV) induces a profound disorganization of the lymphoid tissues with marked abnormalities of the immune system at the terminal stage of ...of simian ...
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Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop.
... fourth virus, SL92d, segregated differently in gag and env trees and had properties of a recombinant viral genome, as described by others (17, 27, ...1 virus and the gag gene of an unknown SIVsm ...new ...
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Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques
... the SIV/DeltaB670 swarm and the macrophage-tropic clone SIV/17E-Fr as previously de- scribed (36, 38, ...to virus inoculation with 2 mg minocycline/kg of body weight twice per day orally and were ...
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Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
... and SIV Env during viral infection has been established (58, 59, 77, 78), but the subse- quent mechanisms by which CD4 and coreceptors mediate viral entry are still not ...from virus strains that use CXCR4 ...
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Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... deficiency virus (HIV) and simian immunodeficiency virus (SIV) that is important for optimal viral replication in the infected ...with SIV containing disruptions of the nef ...
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Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections
... of virus-positive cells by using this ...chronically SIV- infected Asian macaques ...two SIV-infected animals (colon-resident macrophages and jejunum- resident ...of virus-positive cells in ...
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A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation
... of CD8-TL responses against epitopes in these proteins. To test this hypothesis, we analyzed SIV-specific IFN- ␥ ELISPOT results in SIVmac239-infected animals. Peripheral blood mononuclear cells (PBMC) from these ...
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Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins
... human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) preparations by alkylating cysteines of NC zinc fingers, we treated infectious virus ...
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Rhesus Macaque Polyclonal and Monoclonal Antibodies Inhibit Simian Immunodeficiency Virus in the Presence of Human or Autologous Rhesus Effector Cells
... 80% virus inhibition was observed with all five ani- ...5:1, virus inhibition was consider- ably more variable, with two animals demonstrating ⬎ 90% inhibition, two showing 57 and 78% inhibition, and one ...
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Simian Immunodeficiency Virus in Which nef and U3 Sequences Do Not Overlap Replicates Efficiently In Vitro and In Vivo in Rhesus Macaques
... SIV variants containing TPI elements downstream of nef are replication competent and express functional Nef. CEMx174 cells were infected with virus stocks derived from transiently transfected 293T cells to ...
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Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
... the virus after centrifugal ultrafiltration through a 300-kDa cutoff ...treated virus through a Percoll gradient showed that most of the SU did not cosediment with ...the virus during the ultra- ...
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Protective Role of the Virus-Specific Immune Response for Development of Severe Neurologic Signs in Simian Immunodeficiency Virus-Infected Macaques
... blotting. Virus-specific titers for the SIV- specific envelope (Env) protein and the group-specific antigens (Gag) were determined in serum and CSF by an indirect solid-phase fluorescence enzyme immunoassay ...
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Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus Vpx
... the virus replication cycle (37). However, the block to ⌬ vpx virus is not consistent with restriction by TRIM5 ␣ , which is abrogated by preincubation of target cells with VLP, regardless of whether they ...
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DNA Vaccines Expressing Different Forms of Simian Immunodeficiency Virus Antigens Decrease Viremia upon SIVmac251 Challenge
... (ANOVA) to compare each group to the group of the four controls. The P values derived from the repeated-measure ANOVA were adjusted by Dunnett’s method in analyses where multiple groups were compared to the same ...
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Measles Virus Glycoprotein-Pseudotyped Lentiviral Vectors Are Highly Superior to Vesicular Stomatitis Virus G Pseudotypes for Genetic Modification of Monocyte-Derived Dendritic Cells
... are simian immunodeficiency virus (SIV) (60, 66) and human immunodeficiency virus (HIV) lenti- viral vectors (49), but a major drawback is that high vector doses (multiplicities ...
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Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus
... Each SIV expression insert was designed to be noncomplementary to the others in order to avoid recombination events when subsequent SIV-recombi- nant RRV viruses were used to coinfect ...
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Mechanistic differences between HIV 1 and SIV nucleocapsid proteins and cross species HIV 1 genomic RNA recognition
... chimpanzee simian immunodeficiency virus (SIVcpz), a recombinant generated from two distinct monkey SIV lineages [5, 6] (reviewed in [7, ...an SIV from sooty mangabeys (SIVsm) ...
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Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys.
... Characterization of infectious molecular clones of simian immunodeficiency virus SIV mac and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly [r] ...
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Natural Infection of a Household Pet Red-Capped Mangabey (Cercocebus torquatus torquatus) with a New Simian Immunodeficiency Virus
... for simian immunodeficiency virus (SIV) antibody in household pet monkeys in ...nodeficiency virus type 2 (HIV-2)/SIVsm, SIVmnd, and SIVagm antigens, one red-capped mangabey (RCM) ...
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Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein
... a virus-specific immune ...HIV-2, simian immunodeficiency virus from tan- talus monkeys (SIVtan), feline immunodeficiency virus (FIV), and Ebola virus; the Nef protein of ...
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