Slit-Robo
Slit Robo signaling
... additional Slit receptors exist. Indeed, a candidate Slit receptor, Eva1C, first identified in ...in Slit-responsive axons in the mouse (James et ...above, Slit fragments can also bind to the ...
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Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals
... integrating Slit/Robo signals with other cues The remarkable precision of longitudinal trajectories is disrupted by the loss of Slit/Robo ...varying Slit responses, yet individual axons ...
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Myo9b is a key player in SLIT/ROBO mediated lung tumor suppression
... that SLIT/ROBO signaling in neurons and in different types of cancers may use distinct signal transduction ...the SLIT/ROBO/srGAP/CDC42 pathway seems to play a major role in neurons ...for ...
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The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation
... the Slit/Robo signaling pathway. Slit/Robo regulates thalamocortical projections, forebrain commissure formation, axonal guidance, and dendritic spine formation ...[38–40]. Robo is a ...
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Involvement of Slit–Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis
... between Slit (ligand) and Robo (receptor), which acts as a repulsive guidance signal, plays an essential role in the formation of early scaffolds, ...28]; Robo:[29, ...the Slit/Robo ...
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Formation of Cranial Sensory Ganglia: Role of Neural Crest-Placode Interactions, Slit-Robo, and Cadherins
... that Slit–Robo signaling may be responsible for coordinating cell–cell interactions during trigeminal ganglion ...addition, Slit-independent functions of Robo2 may also occur, since Robo–Robo2 ...
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Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling
... impairs Slit production, which normally inhibits EE cell generation by activating Robo signaling in stem ...decreased Slit/Robo signaling triggers an intestinal inflammatory ...
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Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling
... the Slit family have emerged as repul- sive regulators of midline crossing of axons and, more recently, in neuron cell bodies in both vertebrates and invertebrates reviewed by ...the Slit receptors, Robo1 ...
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Thesis_FINAL2.pdf
... between Slit (a repulsive ligand) and Robo (its receptor) 32 , to determine if Crk plays a role in this signaling ...of Robo to negatively regulate Slit/Robo signaling 33 ...of ...
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Osteogenic differentiation of fibroblast like synovial cells in rheumatoid arthritis is induced by microRNA 218 through a ROBO/Slit pathway
... To elucidate the functional consequences of upregula- tion of miR-218, we searched for potential gene targets of miR-218 that might contribute to the osteogenesis of RA-FLS. We performed a DNA microarray using ...
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Slit mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain
... which Slit-Robo signalling was attenuated either in mouse mutants or using dominant-negative approaches in the chick showed strikingly similar ...of Slit- Robo ...of Robo proteins and ...
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Cytoplasmic domain requirements for Frazzled mediated attractive axon turning at the Drosophila midline
... not Slit-Robo or Unc-5 ...fra, robo double mutants have many extra axons crossing the midline, though the defects are slightly less severe than robo single ...fra, robo double mutants ...
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Between Slit and Repulsion: Cell and Molecular Mechanisms Underlying Robo-Mediated Midline Guidance
... the Slit-Robo signaling ...of Robo protein on the commissural portions of axons in kuz mutants, we postulate that Kuz cleaves Robo to regulate receptor ...
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A Slit/miR 218/Robo regulatory loop is required during heart tube formation in zebrafish
... We examined the functional role of the Slit/Robo signaling pathway in the migration of the bilateral heart fields to the midline. In vivo time-lapse confocal microscopy revealed that knockdown of slit2 ...
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Slit and Robo control the development of dendrites in Drosophila CNS
... for Robo in directing growth cones away from the Slit-secreting ...Without Robo, the axons of RP2 motoneurons are misguided medially (Wolf and Chiba, ...same Robo-lacking RP2 neurons also ...
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Search | Preprints
... . Slit/Robo signaling in zebrafish axons has been shown to genetically interact with caspases, in a manner that suggests localized activation [66] ...with Slit/Robo regulation of caspases, we ...
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Moving away from the midline: new developments for Slit and Robo
... the Slit/Robo signalling pathway through the direct interaction of their intracellular domains, which results in the inhibition of netrin attraction (Stein and Tessier-Lavigne, ...
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Non cell autonomous control of precerebellar neuron migration by Slit and Robo proteins
... third Robo receptor, Robo3, is expressed by precerebellar neurons until their leading processes cross the midline (Marillat et ...counteract Slit/Robo repulsion, as proposed for spinal cord ...
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Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors
... by Robo signaling (reviewed by Dickson and Gilestro, 2006). Slit protein is present at the midline and acts as a repellent, activating the Robo, Robo2 and Robo3 ...when Robo signaling is low ...
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Stirring patterns in foaming oxygen steel making slags
... A slice reactor has been constructed to study stirring patterns in jetted liquid/liquid reaction systems of the type found in top blown oxygen steel making processes. The two liquids used in the study have been mercury ...
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