SMAD2/SMAD3
Original Article Effect of TGF-β/Smads signaling in patients with osteoarthritis and osteoarthritis rat model
... control. Smad2, Smad3, and TGF-β1 mRNA expressions were significantly up-regulated in OA patients compared with ...control. Smad2, Smad3, and TGF-β1 mRNA levels were significantly increased in ...
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<p>Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo</p>
... Figure 5 SIN attenuated APAP-induced acute liver injury by decreasing oxidative stress and inflammatory response via regulating TGF-β/Smad signaling pathway. The mice were randomly divided into four groups (n=10): control ...
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Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis
... Abstract: We explored whether transforming growth factor (TGF-β)/Smads signaling pathway influences rheumatoid arthritis (RA)-associated pulmonary fibrosis (PF) and proliferation of RA synovial fibroblast (RA-SF). ...
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Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas
... The sections were examined and scored by two patholo- gists who were unaware of clinical records of patients. For Smad2, Smad3, and Smad4, the cytoplasmic staining pattern was considered to be the positive ...
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Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines
... TGFβR1, smad2, smad3 and smad4 in TMZ- resistant cells (U87TR, U251TR) transfected with pcDNA-RP or ...TGFβR1, smad2, smad3, and smad4 were reduced in the cell transfected with pcDNA-RP ...
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Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1
... TGF-β1, Smad2 and Smad3 between the blank and NC groups (all p > ...TGF-β1, Smad2, Smad3, N-cadherin, and Vimentin presented with no signifi- cant difference in the miR-137 inhibitor + ...
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Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
... that Smad2;Smad3 double heterozygous animals develop normally defines the upper limit of this ...of Smad3 in the context of a Smad2-deficient epiblast eventually disrupts node and axial ...
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Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells
... targeting Smad2 and Smad3 respectively were designed by Wuhan Genesil ...effective Smad2 and Smad3 siRNAs were chosen according to the knockdown effect of Smad2 and Smad3 evalu- ...
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The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
... TGF-β1, Smad2, phospho-Smad2 (p-Smad2), Smad3, phospho-Smad3 (p-Smad3), Smad4, and Smad7 in normal anterior pi- tuitaries, invasive NFPAs, and noninvasive NFPAs and evaluated ...
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How Single Cells Sense Smad3 Signal
... The Tgf-β pathway functions across diverse contexts and tissues, and regulates fun- damental processes, including proliferation, differentiation, morphogenesis, stem- cell maintenance, and regeneration (Massagué, 2012). ...
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Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats
... phosphorylated Smad3 (b). Large numbers of phospho-Smad3-positive cells were detected in the thickened peritoneal membrane of animals with PF (c), and in animals with PF and uremia PF ...blocked ...
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<p>Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3</p>
... and Smad3 was suggested to be a down- stream target of miR-149-3p as con fi rmed by luciferase reporter assay and ...RIP. Smad3, a major transcription factor in transforming growth factor- β (TGF- β ) ...
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Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation
... Cryostat sections from frozen left lung lobe (7 μm) or primary mouse lung fibroblasts cultured on four-well chamber slides were fixed with 4% paraformaldehyde and used for immunofluorescence as described previ- ously ...
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Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
... of Smad3 null mice do not survive longer enough for tumor development after DMBA administration, we are not able to achieve statistically significant results (data not ...since Smad3 null mice have certain ...
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Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor ß signaling
... that Smad3 would be re- quired for SNX9 nuclear membrane bind- ing; and second, in the absence of Smad3, negligible SNX9 would associate with the nuclear membrane following addition of ...into Smad2 ...
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Inhibition of myocyte-specific enhancer factor 2A improved diabetic cardiac fibrosis partially by regulating endothelial-to- mesenchymal transition
... induced Smad2 expression and activity and also attenuated HG-induced EMT in ...of Smad2 as a co-modulator for MEF2 transcriptional regulatory proteins ...
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Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3
... RNA interference (RNAi) is a form of post-transcriptional gene silencing that is mediated by short double-strand RNAs known as small interfering RNA (siRNA). Experi- mental down-modulation of the canonical signal trans- ...
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Transforming growth factor beta1/Smad signalling pathway of aortic disorders: histopathological and immunohistochemical studies
... and Smad2/3 mainly showed a cytoplasmic immunoreactivity in the aor-tic media, Smad4 immunoreactivity was predominantly located in the cytoplasm and/ /or the nucleus of the aortic media, and Smad7 immunoreactivity ...
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Original Article LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression
... To explore the effect of lncRNA TUG1 on cell fibrosis, we overexpressed lncRNA TUG1 in high glucose-suppressed NRK-52E cells and down- regulated the expression of lncRNA TUG1 by small RNA interference strategy. First, we ...
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<p>MiR-145 inhibits EGF-induced epithelial-to-mesenchymal transition via targeting Smad2 in human glioblastoma</p>
... and Smad2 were assessed by Western blot. The silencing of Smad2 was conducted by transfection of Smad2 ...whether Smad2 is a direct target of ...of Smad2 in U87 and U251 cells in a ...
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