Sodium phenylbutyrate
Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Recurrent Advanced Pancreatic Cancer—A Potential Strategy for Improved Survival
... PB—sodium phenylbutyrate; PDGFR—platelet derived growth factor receptor; PI3K—phosphoinositide 3 kinase; PTEN—phosphatase and tensin homolog; PTPRR—protein phosphatase R; RAS—rat sarcoma gene protein ...
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Preliminary Findings on the Use of Targeted Therapy with Pazopanib and Other Agents in Combination with Sodium Phenylbutyrate in the Treatment of Glioblastoma Multiforme
... with sodium phenylbutyrate (PB), a histone deacetylase (HDAC) inhibitor as well as with antineoplastons (ANP), a group of peptides, amino acid derivatives and carboxylic acids that inhibit the growth of ...
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Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Advanced Malignant Mesothelioma: A Strategy for Improved Survival
... PB—sodium phenylbutyrate; PBT—PB and other drugs; PD— progressive disease; PET—positron emission tomography; RR1—ribonucleotide reductase; RT—radiation therapy; SD—stable disease; SPARC— secreted protein ...
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Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Colorectal Cancer after Failure of Second Line Therapy—A Potential Strategy for Improved Survival
... Colorectal cancer (CRC) is the second leading cause of cancer death related mortality with 1.2 mil- lion new cases diagnosed annually worldwide. Despite remarkable advances in the treatment of resectable CRC, advanced ...
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The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells
... Background: Chemotherapy resistance is the main cause of the marginal clinical benefit of platinum-based chemotherapy and tyrosine kinase inhibitors in advanced non-small-cell lung cancer (NSCLC). Thus, the ...
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Profile of sodium phenylbutyrate granules for the treatment of urea-cycle disorders: patient perspectives
... pathways. Sodium benzoate combines with glycine and phenylacetate/phenylbutyrate with glutamine, forming, respectively, hippuric acid and phenylacetylglutamine, which are eliminated in the ...drugs, ...
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The Effect of Antineoplastons A10 and AS2 1 and Metabolites of Sodium Phenylbutyrate on Gene Expression in Glioblastoma Multiforme
... Antineoplastons are peptide and amino acid derivatives that occur naturally in the human body. They inhibit the growth of neoplastic cells without growth inhibition of normal cells. Phenylace- tylglutaminate (PG) is an ...
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Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration
... To determine the effect of SPB on the expression of sur- vivin, p38, p-p38, ERK, p-ERK, JNK, and p-JNK, the whole protein production was extracted from different treatments of the two cell lines for Western blotting ...
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Treatment of Esthesioneuroblastoma and Nonsmall Cell Lung Cancer with Phenylbutyrate
... oral sodium phenylbutyrate ...of phenylbutyrate (PB) and its metabolite phenylacetate on neuroblastoma and lung cancer is documented by numerous preclinical studies and is also evident in this ...
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Pharmaceutical compounding of orphan active ingredients in Belgium: how community and hospital pharmacists can address the needs of patients with rare diseases
... L-carnitine, sodium benzoate and sodium phenylbutyrate solutions and chenodesoxycholic acid, pyridoxal phosphate and primaquine phosphate capsules were stable over 3 months under all storage ...
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A Case of Sustained Objective Response of Recurrent/Progressive Diffuse Intrinsic Pontine Glioma with Phenylbutyrate and Targeted Agents
... Sodium phenylbutyrate (PB) is a drug approved by USA Food and Drug Administration (FDA) for the treat- ment of episodic hyperammonemia in children with inborn errors of urea synthesis ...
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Investigations of the inhibition kinetics of some drugs and chemicals on enzyme of polyphenol oxidase purified from Apricot’s (Salak)
... The assay mixture consisted of 2.8 mL of 0.001 M sodium phosphate buffer (NaPi), pH,7.3, 0.2 ml of 0.1 M catechol and 0.2 mL of enzyme extract. The increase in absorbance at 420 nm was measured. One unit of enzyme ...
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THE EFFECT OF ACUTE ARTERIOVENOUS FISTULA ON RENAL FUNCTIONS
... * The figures given in each experiment for RPF, GFR, FF, plasma sodium, urine volume, amount of sodium excreted, amount of sodium filtered, percentage of filtered sodium reabsorbed by th[r] ...
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Evaluation of Treated Municipal Wastewater Quality for Irrigation
... High sodium content common to recycle water can cause de- flocculating (breakdown) of soil clay particles, severely reducing soil aeration and water infiltration and percola- ...low sodium water, which can ...
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Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro
... All animal care and experimental procedures were approved by the Institutional Animal Care and Use Committee, and the care or use of laboratory animals were conducted in accordance with the guidelines of the Animal ...
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3,4 Dichlorophenoxyacetate interleaved into anionic clay for controlled release formulation of a new environmentally friendly agrochemical
... Release profiles of 3,4-D from the nanohybrid composite, N3,4-D, into various aqueous solutions, sodium phosphate, sodium carbonate, sodium sulfate, and sodium chloride 0.005 M, are show[r] ...
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A Studies on Behaviour of Geopolymer Concrete
... of sodium silicate solutions are ...using Sodium Meta-Silicate, the solid particles weighing equal to ...both Sodium Silicate Gel (Textile Grade) and Sodium Tri-Silicate Solution, it is taken ...
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Nondestructive Evaluation Of Corrosion Damage In Reinforced Concrete Aged Slab Specimen
... of sodium hydroxide used, the amount of external heat needed, and the partial replacement of fly ash by Portland cement in a fly ash-based geopolymer ...fume, sodium hydroxide, and ...
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Spatial distribution of hydro chemical groups of groundwater in different geological and geomorphic settings in various sub basins of Sarada River Basin, Visakhapatnam, India
... In this group as well as in the bicarbonate group, sodium is dominant cation, Ca ++ , Mg ++ both being minor. In several locations in the south and southeast of the study area, there are indications that the ...
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MECHANISMS CONTROLLING CATION CONCENTRATIONS IN THE HUMAN CELL: EVIDENCE FROM THE EFFECT OF IODOACETATE ON Na AND K EXCHANGE RATES OF THE ERYTHROCYTE
... Determination of sodium and potassium exchange rates by the use of radioisotopes showed that the net gain of sodium was caused by a decrease in sodium output with the intake being little[r] ...
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