Solid Malignancies
Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies
... Although the research into CAF subsets and their immunomodulatory properties is in its infancy, they appear to be potent modulators of the immune system and therefore an attractive target for improving T-cell based ...
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Immunological effect of local ablation combined with immunotherapy on solid malignancies
... Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression, metastasis, and response to treatment. Furthermore, several immunotherapeutic ...
6
The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review
... In terms of DFS, the meta-analysis of 13 studies indicated that overexpression of Axl was significantly correlated with a shorter DFS time, with a pooled HR of 1.85 (95% CI 1.44–2.38). No significant heterogeneity and ...
11
A phase I study of high dose rosuvastatin with standard dose erlotinib in patients with advanced solid malignancies
... This was a single-center, phase I open-label study to determine the safety and RPTD of rosuvastatin in com- bination with the standard clinical dose of erlotinib (150 mg/day) in patients with advanced solid ...
11
Targeting immune suppression to improve the Post-surgical outcome of solid malignancies
... many solid malignancies including melanoma and colorectal cancer but is not routinely done in others such as malignant ...of solid cancers due to micro-metastases that have remained undetected or the ...
145
Dysphagia in solid malignancies outside the head, neck and upper gastrointestinal tract
... The previous chapter identified a dearth of robust bedside clinical evaluation tools for use with adults who have solid malignancies outside the head, neck, and upper GI tract. It concluded that screening ...
391
Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis
... carcinoma and some other malignancies. However, the results are controversial or inconclusive. This discrepancy is mostly owing to the genuine heterogeneity, relatively small sample size or different detecting ...
10
Haemostatic abnormalities in solid malignancies
... of solid malignancies are not seen commonly screening in all such cases can guide us to correct those abnormalities in time and improve the ...of solid malignancies and compare their levels ...
5
Current status of sentinel lymph node biopsy in solid malignancies
... BioMed Central World Journal of Surgical Oncology ss Open AcceReview Current status of sentinel lymph node biopsy in solid malignancies Amit Goyal and Robert E Mansel* Address Department of Surgery, U[.] ...
7
Reporting quality of abstracts in phase III clinical trials of systemic therapy in metastatic solid malignancies
... Citations were reviewed from Medline, PubMed, and Embase published between 1 January 2009 and 31 December 2011 to identify eligible publications for ana- lysis. ‘Metastatic” or ‘advanced” were the key words in- cluded in ...
8
Hepatitis B Reactivation in Patients with Hematological and Solid Malignancies: A Retrospective Analysis of Single Center’s Experience
... and solid organ malignancies due to immunosuppressive effect of ...primary solid cancer therapy. Several trials related to patients with solid tumors have suggested the efficacy of preventive ...
8
Recognizing and managing the expanded risk of tumor lysis syndrome in hematologic and solid malignancies
... Tumor lysis syndrome (TLS) is widely recognized as a serious adverse event associated with the cytotoxic therapies primarily used in hematologic cancers, such as Burkitt lymphoma and acute lymphoblastic leukemia. In ...
11
Review Article Old Disease, New Targets Part-I, Solid malignancies
... diffusible glycoprotein produced both by normal and neoplastic cells. It is one of the important regulators for physiologic and pathological angiogenesis. Preclinical studies have demonstrated the efficacy of murine ...
8
Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities
... PBS, solid tumors were cut into 1-3 mm 3 pieces and digested at room temperature for 1 hour on a magnetic stirring apparatus in a solution containing DNAse (Roche, 4536282001), collagenase (Sigma, C5138), ...
12
Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies
... In the current study, confirmed objective clinical re- sponses were seen in 8/58 (14%) patients. All responses were in patients with melanoma or kidney cancer, includ- ing a single confirmed CR. A response rate of 8/45 ...
15
A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies.
... Data from paired tumour biopsies provided evidence of target inhibition at doses of 120 mg; although target modulation in PBMC was observed at doses beyond 30 mg, target inhibition in tu[r] ...
8
Oncogenic protein SALL4 and ZNF217 as prognostic indicators in solid cancers: a meta‑analysis of individual studies
... SALL4, expressively silenced in mature entities, is constitutively enriched in embryonic tissue and serves to maintain self‑renewal capability [3, 4]. Aberrantly reemerging both in vivo and in vitro, SALL4 was first ...
12
The neutrophil-to-lymphocyte ratio (NLR) predicts adrenocortical carcinoma and is correlated with the prognosis
... Adrenocortical carcinoma (ACC) is a very rare disease with an incidence of 0.5 to 2.0 patients/100,000,000 pa- tients/year and has one of the poorest prognoses among all solid malignancies [1, 2]. A large ...
5
Advances and perspectives of PARP inhibitors
... Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies. Rugo HS, Olopade OI, D[r] ...
12
The Effects of Tissue Regenerative Status on Hormesis in Dogs Irradiated during Their Lifespan
... The speed and extent of regeneration/reparation in tissues dosed with 0.003 Gy/day preserved the LS in general populations of Beagle dogs [9]. We con- firmed this conclusion in this study in which we focused on ...
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