soluble CD4
Human Immunodeficiency Virus (HIV) Envelope Binds to CXCR4 Independently of CD4, and Binding Can Be Enhanced by Interaction with Soluble CD4 or by HIV Envelope Deglycosylation
... with CD4 and CXCR4 (18), but the nature of the binding events leading to the formation of this complex and the possibility of a direct interaction between HIV Env and CXCR4 remained specula- ...neuronal ...
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Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4.
... Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 sCD4 neutralization differ in sCD4 binding and glycoprotein gpl20 retention from sCD4-sensitive i[r] ...
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Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies
... of soluble receptor, soluble CD4 (sCD4), or monoclonal antibodies directed against the viral envelope ...the CD4 binding site, the third variable (V3) loop, and CD4-induced epitopes, ...
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Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Identific[r] ...
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Activation of T lymphocytes in dengue virus infections High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon gamma in sera of children with dengue
... of soluble IL-2 receptor (sIL- 2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-gamma (IFN gamma) in the sera of 59 patients with DHF and 41 patients with ...
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Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro
... recombinant soluble CD4 protein (rsT4) blocks both HIV-1 infection of CD4 bearing lymphocytes and syncytium formation in ...(Recombinant soluble CD4 is designated by ...recombinant ...
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Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells
... A soluble form of the CD4 receptor (sCD4) can either enhance or inhibit the infection of cells by simian immunodeficiency virus (SIV) and human immunodeficiency ...into CD4-positive and ...
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CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells.
... Effect of rCD4, CD4-IgG, or V1V2 on syncytium formationa between C8166 cells and HIV-1-infected or HIV-2-infected H9 cells Syncytium formation enhancement of cells infected with: Inhibit[r] ...
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Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1.
... Since primary isolates do not usually replicate well in CD4+ cell lines 21, 22, 63, it is possible that the capacity for growth in such cells and the ability of the viral envelope to bin[r] ...
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Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
... 5007-5012 0022-538X/91/095007-06$02.00/0 Copyright © 1991, American Society for Microbiology Effects of Changes in gpl20-CD4 Binding Affinity on Human Immunodeficiency Virus Type 1 Envel[r] ...
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A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
... Two other MAbs, OKT4 and L120, which are reactive with domains 3 and 4 of CD4, have little or no effect on HIV-1 infection, syncytium formation, or sCD4-induced conformational changes in[r] ...
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Human immunodeficiency virus type 1 envelope gp120 is cleaved after incubation with recombinant soluble CD4.
... To study the potential role of proteolytic cleavage of HIV-1 gpl20 in virus infection, we analyzed by immunoblot procedures highly purified, concentrated viable virus prepa* rations afte[r] ...
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Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein.
... Incubation of cells, expressing moderate amounts of gpl20 after infection with 3.3 PFU of recombinant virus, with high concentrations of sCD4 20 ,ug/ml at 37°C led to a significant decre[r] ...
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Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4.
... Here we report the selection of an HIV-2 strain, LAV-2/B, which directly induces cell-to-cell fusion and efficient infection of certain CD4- human cell lines.. Other HIV-2 strains, howev[r] ...
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Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
... We demonstrate that, at 37°C, the affinity of the binding reaction between sCD4 and HIV-1 IIIB and RF virions is experimentally indistinguishable from that for the reaction between sCD4 [r] ...
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Soluble CD4 enhances simian immunodeficiency virus SIVagm infection.
... 6252 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The CD4 molecule is expressed on T-helper cells and serves as the cellular receptor for the human immunodeficiency [r] ...
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Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Human imm[r] ...
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Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.
... and CD4 occur has been well documented and lends credence to the model of receptor-mediated activation of fusion (1, 51), whereby the binding step triggers a complex series of changes in conformation that ...
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The HIV-1 gp120 Major Variable Regions Modulate Cold Inactivation
... Changes in the conformation sampled by the HIV-1 Env gps have been shown to modulate sensitivity to both sCD4 neutraliza- tion (11, 13) and cold inactivation (8, 18). Therefore, we asked whether the cold inactivation ...
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Production and Characterization of a Soluble, Active Form of Tva, the Subgroup A Avian Sarcoma and Leukosis Virus Receptor
... of soluble CD4 (sCD4) with human immunodeficiency virus type 1 (HIV-1) envelope results in dissociation of gp120 from gp41 (47), acquisition of protease sensitivity by HIV-1 Env (56), and alterations in ...
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