Soluble interleukin-6 receptor
Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum
... IL-: Interleukin-; JAK: Janus kinase; KCO: Transfer coefficient; LABC: Lower airway bacterial colonization; LLOQ: Lower limit of quantification; mAb: Monoclonal antibody; mMRC: Modified Medical Research Council ...
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Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses
... membrane-bound receptor, the soluble form elicits exten- sive antiviral activity in response to infection by DNA and RNA viruses via activation of the type I IFN ...
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Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin 6 receptor alpha
... whose receptor contains gp130 (10), does activate the inflammatory response of these cells ...truncated, soluble IL-6R a can confer IL-6 sen- sitivity to cells containing gp130 (12), including ...
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Construction and Characterization of a Replication-Deficient Adenovirus Expressing Rat-Soluble Interleukin-6 Receptor
... To investigate the physiologic role of sIL-6R in an animal model, we constructed a replica- tion-deficient adenovirus vector carrying the gene encoding the extracellular domain of IL-6R.[r] ...
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Relationship of Interleukin-6 Trans-Signaling and Coronary Heart Disease in Young Adults: a Case-Control Study in Indonesia
... including soluble interleukin-6 receptor (sIL-6R), soluble glycoprotein 130 (sgp130), and intercellular adhesion molecule 1 (ICAM-1) and CHD in young ...
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Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis
... SSc. Interleukin (IL)-6 is implicated in the pathogenesis of SSc. IL-6 is increased in the peripheral blood and lesional skin from patients with SSc, and induces fibroblast collagen production ...
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Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children
... years). Interleukin-1 receptor antagonist (IL-1RA), soluble IL-2R (sIL-2R) (sCD25), IL-6, IL-8, tumor necrosis factor alpha (TNF- a ), soluble TNF receptor type II (sTNF-RII) ...
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Serum Levels of Interleukin-2 and Interleukin-2 Soluble Receptor in Patients with Vitiligo
... cytokines interleukin-1α, interleukin-1β, and interleukin-12 measured in epidermis fluid, were presented in patients whose response to melanocyte transplantation was unsatisfactory ...
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Polymorphisms rs1800795 of interleukin-6 and rs2228145 of interleukin-6 receptor genes in Euro-Brazilians with adult-onset type 1 diabetes mellitus
... membrane receptor (IL-6R, Chr1, 1q21.3; OMIM 147880) or soluble receptor (sIL-6R), and the complex IL-6–IL-6R or IL-6–sIL-6R couples with gp130 protein to trigger intracellular ...
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Methotrexate use, not interleukin 33, is associated with lower carotid intima-media thickness in patients with rheumatoid arthritis
... ultrasound. Interleukin-33 and its soluble receptor serum levels were measured by ...median interleukin-33 and its soluble receptor concentration was ...serum ...
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Soluble interleukin 18 receptor complex is a novel biomarker in rheumatoid arthritis
... Recently, the cytokine milieu of the joint in RA patients has become well-understood, and data from human clinical trials are now available. Therapies designed to block the effects of inflammatory cytokine tumor necrosis ...
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Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross sectional study
... (C-PTHrP), soluble interleukin-2 receptor (sIL-2R) and interleukin (IL)-6, and an osteo-destruction marker, deoxypyridinoline, in synovial fluid (SF) samples obtained from 22 HTLV-I ...
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Serum soluble interleukin 6 (IL 6) receptor and IL 6/soluble IL 6 receptor complex in systemic juvenile rheumatoid arthritis
... ELISA, soluble human IL-6 receptor (sIL-6 R) levels were measured in the sera of 20 healthy children and of 25 patients with systemic juvenile rheumatoid arthritis ...
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Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice
... IL-6 receptor (mIL-6R) mAb, ...purified soluble (s) mIL-6R in CFA (subcutaneously), followed 2 wk later by four 50- m g boosts of smIL-6R in Freund’s incomplete adju- vant once a wk ...
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Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls
... leptin, interleukin 6 (IL-6), and soluble uro- kinase plasminogen activator receptor (suPAR) were asso- ciated distinctively with adiposity, lipodystrophy and sarcopenia, in ...
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Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells
... RT-PCR was performed on cerebral artery tissue col- lected from the groups at 2 weeks for VSMC marker, matrix remodeling, and inflammation genes. A histological study of saccular IAs in 66 patients found that increased ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... IL-1 receptor was not ...the receptor complex. Both proteins bound rap- idly to the receptor upon IL-1 stimulation and remained asso- ciated with the complex for at least 1 ...
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Th17 and Th22 cells in psoriatic arthritis and psoriasis
... T-cell receptor (eBioscience), biotin-labelled anti-IL-23R (R&D Systems, Minneapolis, MN, USA) used with Qdot 605 streptavidin conjugate (Invitrogen), PE-labelled anti-CCR6 (BD Biosciences), ...
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TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling
... The microenvironment significantly affects disease progression [28]. In our previous works, we showed that IPF paracrine signaling significantly alters N-HLF phenotype [4]. Most works discussing IL-6 usually ...
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Evaluation of the immunomodulatory effects of a South African commercial traditional immune booster in human peripheral blood mononuclear cells
... human soluble IL-2 receptor (sIL-2R) levels were carried out using the IL-2 Receptor Human ELISA Kit from ABCAM® (England) and done according to the provided ...IL-2 receptor concentrations ...
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