Soluble VEGF receptor-1
High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study
... and soluble thrombomodulin (sTM) [4,8] are indicators of endothelial activation, glycocalyx degradation and endothelial cell damage, respectively; events that contribute directly to trauma pathology by enhancing ...
8
The association of angiogenic factors and chronic kidney disease
... suggested VEGF expression was reduced in the biop- sied kidney tissue from patients with diabetic nephropathy ...Elevated soluble VEGF receptor-1 (sVEGFR-1) and reduced VEGFR-2 ...
8
Human Trophoblast Progenitor Cells Express and Release Angiogenic Factors
... factor receptor 1 (VEGFR1), and vascular endothelial growth factor receptor 2 (VEGFR2) at protein and mRNA level in comparison with human umbilical vein endothelial cells (HUVECs), revealed that ...
9
Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration
... a VEGF trapping agent (aflibercept) ...with VEGF. Vitreous fluid levels of soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 are reported to be elevated in ischemic vitreoretinal ...
6
Circulating protein biomarkers in systemic sclerosis related pulmonary arterial hypertension: a review of published data
... sFLT-1, soluble vascular endothelial growth factor receptor 1; PlGF, placenta growth factor; VEGF-A, vascular endothelial growth factor A; GDF-15, growth differentiation factor-15; ...
8
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
... the receptor is expressed by adult, differentiated RPE ...both VEGF and VEGFR2 by adult RPE suggests the existence of an autocrine function for VEGF in vivo, an observation previously shown for RPE ...
7
Virus-Induced Decline in Soluble Vascular Endothelial Growth Receptor 2 Is Associated with Plasma Leakage in Dengue Hemorrhagic Fever
... the soluble form of VEGFR2 and enhanced surface VEGFR2 ...in soluble and surface ...and VEGF signaling in ...recombinant VEGF (1 ng/ml), and the amount of phosphorylated VEGFR2 was ...
9
The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia
... including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endothelial cell proliferation and has basic role in ...vasculogenesis. VEGF and its tyrosine kinase receptors ...
12
Alterations in plasma soluble vascular endothelial growth factor receptor-1 (sFlt-1) concentrations during coronary artery bypass graft surgery: relationships with post-operative complications
... elevated VEGF levels following CABG surgery [8,9], suggesting that VEGF is a component of the inflammatory network after open heart ...plasma VEGF levels were higher in patients with cardiovascular ...
6
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
... to VEGF-A, VEGF- C, PDGF, hepatocyte growth factor, and CSF, respectively (Figure ...all receptor–ligand interactions could be detected by plate-based binding, which may be a consequence of steric ...
16
Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery
... [11,12]. VEGF has been characterized as a heparin binding angiogenic growth factor displaying high specificity for endothelial ...of VEGF is stimulated in response to hypoxia and by a wide range of ...
7
Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal.
... growth factor (VEGF) and related ligands include VEGFR1 (Flt-1), VEGFR-2 (KDR/ Flk-1), and VEGFR-3 (Flt-4).The interaction may facilitate the presentation and binding of VEGF to its ...
10
Expression and characterization of a soluble VEGF receptor 2 protein
... We initially chose to transfect HEK293 cells in a 48-well plate at 80–90% confluency. However, given the relatively long experimental period, the cells invariably became fully confluent within 24 h of transfection. The ...
10
The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model
... by VEGF-A, whereas lym- phangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial ...by soluble VEGFR-3 (sVEGFR-3) or the blocking ...
13
Is inflammation the cause of pre-eclampsia?
... Increases in inflammatory cytokine production have been associated with endothelial dysfunction, increased placenta apoptosis, decreased angiogenesis and kidney abnormalities that are relevant to the pathophysiology of ...
9
Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children
... and soluble immunological re- ceptors in sera bears diagnostic relevance in many ...cytokines, soluble receptors, and mediators in serum in healthy children (3 to 17 years of ...Interleukin-1 ...
5
Gonnermann, Claudia (2004): Der Interleukin-1-Genkomplex in der Schizophrenie. Dissertation, LMU München: Medizinische Fakultät
... Hirngewebe (Henneberg et al. 1993; Kelly et al. 1987; Pandey et al. 1981; Yang et al. 1994). Dabei wurden erhöhte Antikörpertiter gegen hippocampale Strukturen (Ganguli et al. 1987; Ganguli et al. 1993; Yang et al. ...
164
A high angiopoietin 2/angiopoietin 1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia
... [37], so that ex vivo platelet activation can result in fal- sely elevated Ang-1 levels, limiting the accuracy of the Ang-2/Ang-1 ratio. Accordingly, the effect of pre-analy- tical variables, such as sample ...
10
Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway
... of VEGF, KDR, and Cav-1 were analyzed with ...with 1 lg total RNA from each sample using random ...eters: 1 cycle, 95 °C, 5 s; 40 cycles, 95 °C 10 s, 57 °C, 30 ...C; VEGF, sense: GGC ...
9
Abstract
... were determined using a solid phase ELISA kit (R&D Systems, Minneapolis, MN, USA). The assays use the quantitative sandwich enzyme immunoassay technique using antibodies raised against recombinant human VEGF ...
6