spinal nerve ligation
Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation
... from spinal nociceptive neurons to higher order neurons in the contralateral ventral posterolateral thalamic nucleus (VPL), which is involved in sensory-discriminative aspects of pain processing [23], but also in ...
23
TWIK Related Spinal Cord K+ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
... after spinal nerve ligation (SNL), TRESK expression was dra- matically reduced in the ipsilateral DRG (D) ...TWIK-related spinal cord K + ; DRG, dorsal root ...
9
Age-Related Differences in Neuropathic Pain Behavior and Spinal Microglial Activity after L5 Spinal Nerve Ligation in Male Rats
... of spinal microglia and its association with the development of neuropathic pain remains unknown, we also evaluated the expression of spinal Iba1, a microglial marker, by using western blotting before and 5 ...
10
ANTIALLODYNIC AND ANTIHYPERALGESIC ACTIVITIES OF ANTICONVULSANT GABA DERIVATIVES IN BOTH SCIATIC NERVE AND SPINAL NERVE LIGATION MODELS OF NEUROPATHIC PAIN
... There is considerable research evidence supporting a palliative role for γ-aminobutyric acid (GABA)ergic neurotransmission and voltage-gated sodium channel blockade in neuropathic pain conditions. Hence, the present ...
14
Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation
... of nerve injury-induced neu- ropathic ...L5/6 spinal-nerve ligation in ...L5/6 spinal nerve ligation (SNL), Sprague-Dawley male rats were intrathecal- ly administered ...
9
Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study
... TRPA1 and TRPM8 receptors in the reduction of pain behaviors in response to cold stimuli. Both TRPA1 and TRPM8 expressions are increased following peripheral nerve injury and mRNAs encoding both were significantly ...
9
Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation
... touch, a normally innocuous stimulation. Touch-evoked pain is a hallmark of neuropathic pain and is triggered by spontaneous ectopic discharges from injured periph- eral nerves to sensitized spinal dorsal horn ...
10
Pro-resolving mediator maresin 1 ameliorates pain hypersensitivity in a rat spinal nerve ligation model of neuropathic pain
... mine the effects of MaR1 on the activation of NF- κ B in ipsilateral L4–L5 spinal cord following SNL, we examined the activity of NF- κ B on day 7 after surgery using immu- nofluorescence and Western blot. ...
9
Original Article Intervention of Toutongning on early neuralgia in rats by inhibiting P2X3 and CGRP expression
... group, spinal nerve ligation model group (SNL group) and Toutongning group (SNL+TG group), 10 rats in each ...L5 spinal nerves and they were ligated with silk threads to suture muscle and ...
6
Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia
... peripheral nerve injury causes changes in expression of some growth factors in the dorsal root ...peripheral nerve injury in the spinal dorsal horn; however, it remains unknown whether the expression ...
8
Identification of key genes and pathways associated with neuropathic pain in uninjured dorsal root ganglion by using bioinformatic analysis
... Purpose: Neuropathic pain is a complex chronic condition occurring post-nervous system dam- age. The transcriptional reprogramming of injured dorsal root ganglia (DRGs) drives neuropathic pain. However, few comparative ...
10
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
... spinal nerve ligation (SNL)-induced neuropathic pain ...in spinal glia, play an important role in signaling cascades of inflammatory mediators during nerve injury-induced neuropathic ...
10
NMDA RECEPTOR ANTAGONISTS ATTENUATE TOLERANCE INDUCED BY MORPHINE AND NERVE LIGATION IN MICE
... addition, nerve damage that affects peripheral nerves leads to abnormal pain states referred to as neuropathic ...sciatic nerve, has been studied exten ...
8
MR Imaging in Human Rabies
... unmyelinated nerve ending at the bitten site, the virus reaches the central nervous system (CNS) by retrograde axoplas- mic flow (1, ...innervated nerve fibers, ...
8
Case Report Minimally invasive transforaminal endoscopic treated neurologic deficit after percutaneous kyphoplasty-a case report
... the spinal canal, causing compression of the spinal cord and/or nerve roots and ischemic injury, is a well-recog- nized complication of PKP resulting in acute neurological ...the spinal canal, ...
5
Contrast enhancement in spinal nerve roots: an experimental study
... The spinal nerves were sectioned distal to the dorsal root ganglion at each level, and the dural sac and spinal cord were transected at ...the spinal canal and placed in 10% buffered formalin for ...
6
Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons
... for spinal microglia activation during neuropathic pain ...the spinal microglia ...the spinal dorsal horn of naive animals but not in CCR2-deficient mice ...a spinal injection of CCL2- ...
10
Spontaneous Extracranial Vertebral Artery Dissociation: A Case Report and Review of the Literature
... the nerve roots in the transverse ...C6 nerve roots by expansion of the vertebral artery wall within the intervertebral foramina associated with vertebral artery dissec- tion ...but nerve root ...
6
Nervous System
... sciatic nerve tibial nerve spinal cord cervical nerves brain cranial nerves common fibular nerve thoracic nerves lumbar nerves sacral nerves.. Copyright © The McGraw-Hill Companies, Inc.[r] ...
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Comparison of Success Rate of Inguinal Approach Versus Classical Pubic Approach for Obturator Nerve Block in Patients Undergoing TURBT
... obturator nerve is derived from the 3rd to 4th lumbar nerves with a minor contribution from ...The nerve descends on psoas muscle and lies deep in obturator canal (which is bordered by the obturator ...
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