SRC gene
Noncoding region between the env and src genes of Rous sarcoma virus influences splicing efficiency at the src gene 3' splice site.
... DISCUSSION We have shown in this paper that different cloned variants of Prague RSV vary in the efficiencies of splicing at the src gene 3' splice site resulting in two- to threefold dif[r] ...
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Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product.
... To examine the expression of the altered src gene, chicken embryo cells were infected with PrA RSV or with tdCH20 either viral DNA or virus from transfected cells and labeled with [35S]m[r] ...
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Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation.
... Src gene product from different strains of avian sarcoma virus: kinetics and possible mechanism of heat inactivation of protein kinase activity from cells infected by transformation-defe[r] ...
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Common features of the yes and src gene products defined by peptide-specific antibodies.
... By using anti-peptide antibodies generated against a carboxy-terminal region of pp6OSrc 17, the srcencoded protein product, which were cross-reactive with the yes gene products, we have [r] ...
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Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo.
... A, Uninfected cells labeled with 32Pi and precipitated with antitumor serum; B, uninfected cells labeled with 32Pi and precipitated with absorbed antitumor serum; C, uninfected cells lab[r] ...
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Evidence the pp60src, the product of the Rous sarcoma virus src gene, undergoes autophosphorylation.
... Figure 4A, track 2, shows that pp60Orc prepared in this fashion was able to undergo autophosphorylation; silver staining of this preparation indicated that almost all the protein was pp6[r] ...
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Isolation and structural mapping of a human c-src gene homologous to the transforming gene (v-src) of Rous sarcoma virus.
... FUJITA2* Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824,' and Cancer Research Laboratory and Department of Biochemistry, University of Western Ontari[r] ...
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Characterization of Rous sarcoma virus src gene products synthesized in vitro.
... It is quite unlikely that the large number of peptide differences observed between PR-B and SR-D are simply due to differential Downloaded from http://jvi.asm.org/ on November 10, 2019 b[r] ...
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Herbimycin A, a pp60c src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo
... c-src gene product in mice indicates that the pp60c-src tyrosine kinase is required and essential for osteoclastic bone resorption, we tested the effects of the antibiotic herbimycin A, which is an ...
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Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
... Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of Herpes simplex virus type 1.. Predicted n[r] ...
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A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens.
... In an attempt to examine the role of gag determinants of gag-frs fusion proteins in cellular transformation, viral DNA was constructed so that the src gene of Rous sarcoma virus was repl[r] ...
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View and review on viral oncology research
... cancer-causing gene (oncogene) was named src according to the type of tumor caused by RSV in chickens, the ...the src gene for RSV replication lead to the hypothesis that oncogenes have a ...
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Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.
... Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp6Osrc inactivate tyrosine protein kinase activity.. Myristic acid is attached to the [r] ...
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Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.
... 1927 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest A monoclonal antibody, R2D2, raised to the src gene product of Rous sarcoma virus was found to inhibit the tyrosine[r] ...
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Suppression of v-src Transformation by the drs Gene
... v-src gene also positively or negatively alters the expression of many cellular genes (1, 6, 12, 14, 16, 28, 33, 40, 44, 45, ...novel gene, drs (downregulated by v-src), which was ex- pressed ...
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The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides.
... We found that the subgenomic mRNA's that direct the synthesis of the env and src gene products have uninterrupted spliced leader sequences of approximately 390 nucleotides, whereas virio[r] ...
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<p>SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1</p>
... for SRC (si-SRC, 5 ʹ -CC AAGGGCCUCAACGUAA-3 ʹ ), SIRT1 (si-SIRT1, 5 ʹ -CCA UCUCUCUGUCACAAAUTT-3 ʹ ) and their corresponding negative controls (si-NC) were purchased from Ribobio (Ribobio, ...for SRC ...
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1,25 dihydroxyvitamin D3 stimulates phospholipase C gamma in rat colonocytes: role of c Src in PLC gamma activation
... L -1-chloro-3-[4-tosylamido]-4-phenyl-2-butanone, 0.1 mM L -chloro- 3-[4-tosylamido]-7-amino-2-heptanone-HCl, 10 mg/ml leupeptin, 1 mM sodium vanadate, 100 mM AEBSF, 10 mg/ml aprotinin, 50 mM b-glyc- erophosphate, 10 mM ...
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Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon cancer
... agent Src inhibitors have been applied in clinical trials, preclinical studies hinted that a combined therapy might greatly increase the efficiency of Src inhibitors in colon cancer ...of Src ...
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Expression patterns of Src family tyrosine kinases during Xenopus laevis development
... yes, src, lyn and csk transcripts in the animal pole portion, less in the marginal zone portion and still less in the vegetal pole portion of the ...Yes, src, lyn and csk transcripts formed concentration ...
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