Src-homology domain 2
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy
... Data analysis of the CNV beadchip experiments was conducted by using DosageMiner software (deCODE Genetics). The loss/gain analysis consisted of the follow- ing 4 steps: (1) intensity normalization and GC content ...
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SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome
... Recruitment of SH2 domain proteins to phosphorylated sites is a dynamic process and is by no means predeter- mined by the phosphorylation event alone. Each tyrosine site on a scaffold (including sites on receptors ...
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The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase 1 and Notch signaling
... VEGF signaling regulates EC polarization and Rho GTPase- dependent non-muscle myosin-induced cell shape changes required for vessel luminization (Strilic ́ et al., 2009). Thus, we determined whether enlargement and ...
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Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas
... SEREX is one of the most powerful tools to find novel tumor antigen for various cancers [5], and some autolo- gous antigens to esophageal cancer have been identified in our groups [29-31]. Compared with other screening ...
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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
... Age-related changes in T cell subset composition in- volve a reduced frequency/number of naïve T cells, in- creased number of memory T cells and increased proportion of CD28 - T cells, especially in the CD8 + sub- ...
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The role of SH3BP2 in the pathophysiology of cherubism
... SH3BP2: src homology 3 binding protein 2; PH: pleckstrin homology domain; PR: proline-rich domain; SH2: Src- homology 2 domain; Tyr: Tyrosine; Glu: ...
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Deficiency of Src homology 2 domain–containing inositol 5 phosphatase 1 affects platelet responses and thrombus growth
... washing for 2 minutes at the same shear rate with PBS. Thrombus for- mation was visualized with a ×40 long-working-distance objective in real time (acquisition rate: 1 frame every 5 seconds) for both fluorescent ...
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Phospholipase C-γ Contains Introns Shared by src Homology 2 Domains in Many Unrelated Proteins
... Figure 2.—(A) Intron positions in eight PLC-␥ genes. The location of every intron in each species is shown by a triangle above a schematic representation of the PLC-␥ protein; the phase of splicing for each intron ...
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Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
... of homology termed Janus homol- ogy (JH) domains 1–7 ...JH1 domain, shares the features of other tyrosine kinase ...molecule src homology (SH)2Bβ, an SH-2 domain containing ...
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WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain- containing protein tyrosine phosphatase 1
... including Src, Akt, ERK and FAK, which regulate endothelial cell survival, proliferation and motility [16, ...as Src, Akt, ERK and FAK in HUVECs exposed to ...
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SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer
... that Src homology phosphotyrosyl phos- phatase 2 (SHP2) is an essential downstream effector of EGFR signaling ...phosphatase domain in the C- terminal region ...
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Original Article Down-regulation of MiR-365 as a novel indicator to assess the progression and metastasis of hepatocellular carcinoma
... protein Src homology 2 domain-con- taining 1 (SHC1) and apoptosis-promoting pro- tein BAX in pancreatic cancer cells [28], neuro- pilin 1 (NRP1) in malignant melanoma [37], thyroid ...
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src homology 2 domain–containing tyrosine phosphatase SHP 1 controls the development of allergic airway inflammation
... SH2 domain– containing tyrosine phosphatases, are increasingly being shown to play key roles in T cell development and signaling ...dephosphorylating src-family PTKs, such as Lck and Fyn (28), as well as ...
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T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells
... the Src homology 2 (SH2) domain of the actin regulator Non-catalytic region of tyrosine kinase adaptor protein (Nck) potentially binds to TSAd phosphorylated on Tyr 280 (pTyr 280 ) and pTyr ...
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Mannell, Hanna (2007): The role of Src-homology 2 domain containing tyrosine phosphatase 2 in growth factor dependent endothelial signalling and angiogenesis. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Grb 2-associated binder 1 (Gab-1) binds SHP-2 upon EGF, PDGF and bFGF stimulation 91,92,99,133 and that this seems to be important for at least EGF and PDGF induced SHP-2 dependent signalling ...
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A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
... 338 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The v-src oncogene of Rous sarcoma virus RSV is able to transform both avian and mammalian cells, but the mutant all[r] ...
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Human resistin and the RELM of Inflammation in diabesity
... head domain also consists mainly of an α-helical coiled-coil ...sequence homology of the two proteins, as well as location and functional differences of mouse and human ...
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Cytoskeletal signaling proteins : complex regulatory mechanisms and roles in innate immunity
... FERM domain of ...N-terminal domain of Pyk2 (Pyk2ΔN) failed to associate with Syk ...FERM domain of Pyk2, expressed as a citrine- FERM domain fusion protein, Syk was co-immunoprecipitated with ...
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Biochemical and functional characterisation of phospholipase C η2
... The human LIMK1 plasmid fused to a c-myc tag on the C-terminus and cloned into pcDNA3.1 was kindly provided by Prof. Michael Olson (Beatson Institute, Glasgow, UK). The 75–1238 residues of mouse PLCη2 (isoform a; ...
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Sequence of the Long Terminal Repeat and Adjacent Segments of the Endogenous Avian Virus Rous-Associated Virus 0
... A direct comparison of the sequences between src and the LTR of SR-A with the region between env and the LTR of RAV-0 reveals a region of homology beginning at the LTR of about 120 base [r] ...
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