Src kinase
Src kinase inhibition promotes the chondrocyte phenotype
... the Src family kinases, in regulating the chondrocyte ...the Src family kinase Lyn exhibits a dynamic expression pattern in the chondrogenic cell line ATDC5 and in a mixed population of embryonic ...
12
The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii
... of Src kinases on the biology and pathogenesis of Acanth- ...that Src kinase inhibitor, PP2, but not its inactive analog, PP3, abolished ...that Src kinases have a pivotal role in the growth ...
9
Effects of Src-kinase inhibition in cancer-induced bone pain
... that Src expression is necessary for normal bone resorption, as these animals develop osteo- petrosis, 35 and the most critical role for c-Src in bone is related to osteoclast function rather than ...
14
Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors
... 5. Ma J.G., Huang H., Chen S.M., Chen Y., Xin X.L., Lin L.P., Ding J., Liu H. and Meng L.H. PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro ...
5
Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM
... then extends further before bifurcating. We observed that the longest neurite, destined to become the axon was reduced in length by PDN1, but not PDN1(P5A) expression (Fig. 4a,b). In addition, longest neurite branching ...
10
Regulation of the Src Family Kinases by Csk
... Although the molecular mechanisms of SFK ac- tivation may vary depending upon cell types and ex- tracellular cues, it is now believed that in general, full activation of SFK is achieved in the following order (Fig.2B): ...
13
Differential pp60c src activity in well and poorly differentiated human colon carcinomas and cell lines
... revealed src kinase activity comparable to that observed in normal colonic mucosa, considerably less than that observed in moderate/well differentiated ...of src kinase activity with ...
8
Suppression of v-src Transformation by the drs Gene
... tyrosine kinase activity of v-Src protein in MRSV-infected cells was examined by in vitro protein kinase assay with anti-Src ...v-Src kinase activities of F-drs-2, -4, and -7 ...
6
Nck adapter proteins: functional versatility in T cells
... the Src kinase Fyn to ...its kinase activity enabling the intense phosphorylation of SLAM, the recruitment of further downstream proteins and thus propagates signaling ...
13
Participation of Morphofunctional Zones in Aging Processes
... enhances Src kinase expression in the hypothalamic center, synthesizing ...because Src kinase reduces ...which Src kinase expression and accordingly a pituitary FSH ...is ...
7
Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation.
... the src kinase domain increases enzyme activity, whilst phosphorylation of tyrosine 527 by Csk reduces activity of the ...of src in a panel of isogenic cell lines modelling resistance to ...
34
Rhinovirus Activates Interleukin-8 Expression via a Src/p110β Phosphatidylinositol 3-Kinase/Akt Pathway in Human Airway Epithelial Cells
... Src kinase activity is required for the IL-8 response to ...Since Src is associated with focal adhesion com- plexes and phosphorylates p85 (15), we tested the dependence of IL-8 production induced by ...
9
Different effects of the inhibition of Src activity on Akt/PKB in melanoma cells with wild BRAF and mutated BRAF V600E
... of Src tyrosine kinase activity in the regulation of the mTOR signaling pathway in v-src-transformed ham- ster fibroblasts [12] and in HBL human melanoma cells ...of Src kinase acti- ...
6
Suppression of arthritic bone destruction by adenovirus mediated csk gene transfer to synoviocytes and osteoclasts
... RA. Src family tyrosine kinases are implicated in various intracellular signaling pathways, including mitogenic response to growth factors in fibroblasts, activation of lymphocytes, and osteoclastic bone ...
11
Association of pp60src and src protein kinase activity with the plasma membrane of nonpermissive and permissive avian sarcoma virus-infected cells.
... When subcellular components of the cell were fractionated by discontinuous sucrose gradient centrifugation, similar amounts of both pp60 and src protein kinase activity cosedimented with[r] ...
11
Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells
... Blocking FAK activity through the use of PF573228 exacer- bated the ILTV CPE (Fig. 7A). The level of apoptosis induced by ILTV in cells pretreated with PF5732228 was nearly 2-fold higher than that in DMSO-treated cells ...
13
Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration
... protein Src as an important player in the regulation of the MT-FA crosstalk. Src interacts with and phosphorylates end-binding protein 1 (EB1), a member of MT plus end-tracking proteins (+TIPs), both in ...
12
pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.
... gest that PP2A influences the final location of the MT complex rather than MT controlling the distribution of its associated proteins, as is usually envisaged. However, we cannot yet for- mally exclude a more indirect ...
9
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells
... tyrosine kinase that is regulated by SFK (Figure 5). SU6656, and Src-1, two other small molecule SFK inhibitors [25,26] were also tested, but found to be much less potent than PP2 in reducing overall pY ...
11
Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.
... 11 Autophosphorylation Is Required for High Kinase Activity and Efficient Transformation Ability of Proteins Encoded by Host Range Alleles of v-src KATHLEEN M.. VERDERAMEl12* Cell and Mo[r] ...
8