STAT activation
A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus
... sustained STAT phosphorylation and activation in epithelial cells, we examined STAT activity in two sets of paired cell lines, HeLa, an EBV-converted HeLa cell line, HeLa-Bx1, the NPC-derived cell ...
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Asymmetric localisation of cytokine mRNA is essential for JAK/STAT activation during cell invasiveness
... components of the cytoskeleton and signalling molecules. Some well-characterised examples include Veg1 and An1 mRNAs in Xenopus, the localisation of which determines the vegetal and animal poles of the embryo (Mowry and ...
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Pegylated IFN α regulates hepatic gene expression through transient Jak/STAT activation
... A large body of fundamental knowledge about the key signaling pathways and the biological role of IFN-α has been acquired through cell culture exper- iments and mouse models with genetic deletions of IFNs, IFN receptors, ...
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Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck.
... induces STAT DNA-binding ...This activation was dependent upon the presence of p56 lck , as there was no STAT activation in the JCam cell ...
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Abstract
... Jak/STAT activation in RA describes constitutive STAT−3 DNA binding activity in freshly isolated RA mononuclear ...on STAT−3. The objective was to evaluate the activity of STAT−3 in ...
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Abstract
... of STAT proteins in autoimmune inflammatory arthritis are not fully understood, but preliminary research on STAT activation dur− ing synovitis has been ...of STAT activation in ...
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The stem cell niche: lessons from the Drosophila testis
... If STAT activation in GSCs does not mediate their self-renewal, then what does it do? Testes that are globally depleted of stat lose both populations of stem cells, but CySCs can be rescued by ...
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The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
... JAK/STAT activation is driving disease has implications for determining the effect of JAK inhibitors upon the malignant clone in MPNs, illustrated by comparison with chronic myeloid leukaemia ...promote ...
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Signaling Pathways Activated by Interleukin-2 and Interleukin-4 Receptors Mediate T Lymphocyte Clonal Expansion
... Gene activation leads to the increased presence of high affinity IL-2 receptors, which helps promote the T cell response to IL-2 in an autocrine fashion ...regulate STAT activation and prevent ...
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JAK STAT signaling in asthma
... After binding of either IL-4 or IL-13, the activated Jaks phosphorylate tyrosines within the cytoplasmic domain of the IL-4Rα, which act as docking sites for Stat6. Phosphorylated Stat6 homodimerizes, translo- cates to ...
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Signal transduction through JAK1: The effect of a mutant on the induction of class II HLA by interferon-gamma, antiviral responses, and the response to dsRNA
... There is now persuasive evidence pointing to additional ligand-dependent signalling in response to IFNs which cannot be accounted for by the traditional Jak/STAT signal transduction pathway (125, 218, 219). ...
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Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice
... B-cell activation and anti- body production ...STAT3 activation in IL-9-induced B-cell activation, isolated naïve B cells were treated with IL-9 combined with IL-17, the data showed that more in- ...
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DNA methylation controls the timing of astrogliogenesis through regulation of JAK STAT signaling
... the STAT-binding element in the mouse Gfap promoter undergoes demethylation during the neuro- to gliogenic switch in the developing ...the STAT-binding element (5 ′ TTCCGAGAA3 ′ ) within this neuroectoderm ...
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Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation
... JAK/ STAT signaling pathway is involved in the renoprotective properties induced by dexmedetomidine in an in vivo I/ R injury model, we performed additional experiments after taking into consideration the ...
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Herbal formula Xian Fang Huo Ming Yin regulates differentiation of lymphocytes and production of pro inflammatory cytokines in collagen induced arthritis mice
... from full composition granules of XFHM. Several lines of evidence indicate that Veratric acid [33], Loganic acid [34], Paeoniflorin [35], Loganin [36] and apiin [37] have anti- inflammatory and immune-regulatory ...
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Dehydrohalogenation of ethyl halide
... the CBS level of theory, with Table 3 listing the same quantities calculated at both levels of theory. Subsequent discussion relates to the values derived by the CBS-QB3 method. Ethyl chloride (S1) and ethyl bromide (L1) ...
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Bis(maltolato)oxovanadium(IV) Activation of STAT-1 Signaling in Fibroblasts as a Potential Therapy for Pulmonary Fibrosis.
... First, STAT-1 is well-known to be an important regulator of growth arrest and apoptosis in cells of mesenchymal origin, including fibroblasts (Thomas et ...Second, STAT-1-deficient mice develop a more ...
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Neuropeptide FF increases M2 activation and self renewal of adipose tissue macrophages
... and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic ...M2 activation and increased the proliferation of murine and human ...M2 activation and ...
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JAK STAT and AKT pathway coupled genes in erythroid progenitor cells through ontogeny
... After activation of v-akt (murine thym- oma viral oncogene homolog 1 (AKT1)), cell survival is promoted via nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1) and conserved ...
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