Stromal Tumors
Clinicopathological characteristics and prognosis of primary appendiceal stromal tumors
... tinal stromal tumors indicate that lesions of less than 5 cm in diameter located in favorable anatomic sites, such as the greater curvature or anterior wall of gastric body and fundus, can be considered by ...
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Update on imatinib for gastrointestinal stromal tumors: duration of treatment
... Gastrointestinal stromal tumors (GISTs) are the most common sarcoma of the gastrointestinal tract, with transformation typically driven by activating mutations of c-KIT and less commonly platelet-derived ...
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Original Article Clinical features and prognosis of extragastrointestinal stromal tumors
... of stromal tumors, and therefore has been included in the risk rating system for stromal ...of tumors in the mesentery was 50% (11/22), that in the retroperitoneum was ...gastric ...
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Syndromic gastrointestinal stromal tumors
... During the review process and after acceptance of this manuscript, data relevant with respect to SDH-deficient GISTs, one of the main topics of the present review, have been published: 1) Ben-Ami et al. (Ben-Ami E, ...
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Transvaginal excision of rectal stromal tumors: case reports and a literature review
... Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Rectal locations are very rare, and minimally invasive surgery is a good ...
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Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya
... gastrointestinal stromal tumors (GISTs) mesenchymal tumor is very un- ...gastrointestinal stromal tumor depend on the site and size of the tumor, and may include abdominal pain, gastrointestinal ...
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Management of hemorrhage in gastrointestinal stromal tumors: a review
... other tumors, for the following reasons: 1) stromal tumors are generally relatively easy to remove, 2) tumor rupture should be prevented in case of implantation metastasis, and 3) because of the ...
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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
... Approximately 85% to 90% of all cases of gastrointestinal stromal tumors (GIST) are associated with gain-of-func- tion mutations in the gene KIT [1-4]. A further 5% to 10% of cases of GIST are associated ...
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Gastrointestinal Stromal Tumors in the 21st Century
... Gastrointestinal stromal tumors though rare, are the commonest primary mesenchymal neoplasm of the ga- strointestinal ...These tumors are heterogeneous with respect to patient demographics affected, ...
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Gastrointestinal Stromal Tumors: Review Article
... 28 Casali PG et al, Tumor response to Imatinib mesylate in advanced GIST.Proc Am Soc Oncol.2004; 23:821.Abstract 9028 29 DeMatteo et al, and the American College of Surgeons Oncology Group ACOSOG Intergroup Adjuvant GIST ...
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Gastrointestinal stromal tumors: three decades of lessons
... Gastrointestinal stromal tumors have been a diagnostic dilemma to the medical science in the past decades because of the clinical presentation and improper ...These tumors generally arise in the ...
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Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years’ retrospective study in a developing country
... cord stromal tumors from January 1, 1992 to December 31, 2012, whose specimens were received at Histopathology section, Department of Pathology and Microbiology, Aga Khan University Hospital, ...
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Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach
... Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease, overexpression of ...
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Efficacy and Tolerability of Imatinib Mesylate In Advanced Gastrointestinal Stromal Tumors
... Imatinib mesylate is a selective inhibitor of certain protein tyrosine kinases: the intracellular ABL kinase, the chimeric BCR-ABL fusion oncoprotein of chronic myeloid leukemia, the trans-membrane receptor KIT, and the ...
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Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
... Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of ...
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Gastrointestinal Stromal Tumors: Experience from a Single Surgical Unit
... gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract (GIT), overall they are rare neoplasms ranking a distant third in prevalence behind ...
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Targeting gastrointestinal stromal tumors: the role of regorafenib
... While clinical and radiographic findings may be suggestive, the definitive diagnosis of GIST relies on tissue diagnosis. Histologically, GIST can have a variable appear- ance, but has been classified in the past as ...
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Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
... whose tumors were not growing at the time of surgery, limited disease progression or generalized disease progression) and surgical result (no evidence of disease, minimal residual disease or bulky residual ...
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Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.
... in tumors’ >5 cm ...of tumors bearing KIT ...of tumors with KIT delinc557/558, within which tumor size, mitotic rate and fraction of high-risk tumors were also significantly higher than in ...
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Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
... sensitivity analyses using different algorithms to identify recurrence. First, we shortened the time interval between initial surgical resection and detection of a recurrence from 90 to 60 days using the original ...
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