structural biology
Bernal and the genesis of structural biology
... Likewise, structural biology is making major contributions to animal and plant health which, in turn, impact on agriculture and ...that structural biology contributes in a very direct, ...
13
Structural biology of presenilin 1 complexes
... and structural biology of this unusual enzyme ...the structural biology of the presenilin complex is an essential step towards rational design of substrate- and/or cleavage site-specific ...
10
Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques
... advancements, structural biology has begun to tackle more and more difficult questions, including complex biochemical pathways and transient interactions among ...of biology, one single technique is ...
12
Protein structural biology using cell-free platform from wheat germ
... for structural analysis of proteins remains the creation of high-yield and high-purity samples of the target ...for structural biology including single particle analysis with electron microscopy, and ...
13
The basics of small-angle neutron scattering (SANS for new users of structural biology)
... standard structural biology techniques, including membrane proteins, in more biologically relevant ...proteins. Structural flexibility or intrinsic disorder of macromolecules is not a ...push ...
35
Adapting Federated Cyberinfrastructure for Shared Data Collection Facilities in Structural Biology
... Early stage experimental data in structural biology is generally unmaintained and inaccessible to the public. It is increasingly believed that this data, which forms the basis for each macromolecular ...
7
Research Activities and Services in Structural Biology. EMBL Grenoble
... Structural biology is increasingly dependent on integrated and high- throughput technologies to facilitate the determination of protein and pro- tein-complex structures and to allow complementary functional ...
8
Building bridges between cellular and molecular structural biology
... Patwardhan, A. and Brandt, R. and Butcher, S.J and Collinson, L. and Gault, D. and Grünewald, K. and Hecksel, C. and Huiskonen, J.T. and Iudin, A. and Jones, M.L. and Korir, P.K. and Koster, A.J. and Lagerstedt, I. and ...
19
Role of integrative structural biology in understanding transcriptional initiation
... tegrative structural biology approach in which cryo-EM was combined with CLMS and ISD to calculate and interpret EM density for an in vitro- assembled 52-protein Mediator-bound pre-initiation complex ...of ...
20
Mass spectrometry-enabled structural biology of membrane proteins
... utilizing structural MS studies, the labelling reagent(s) used must be carefully ...‘integrated structural biology’ [249]) to create molecular ...with structural techniques such as NMR and ...
19
TarO : a target optimisation system for structural biology
... TarO (http://www.compbio.dundee.ac.uk/taro) offers a single point of reference for key bioinformatics analyses relevant to selecting proteins or domains for study by structural biology techniques. The ...
7
The structural biology of patellamide biosynthesis
... The biosynthetic pathways for patellamide and related natural products have recently been studied by structural biology. These pathways produce molecules that have a complex framework and exhibit a diverse ...
10
Structural biology of arf and rab GTPases' effector recruitment and specificity
... share structural properties that are not observed in Rho and Ras family ...similar structural features adopted by Arf and Rab proteins (Figures 6A and 6B) compared to Ras and Rho proteins (Figures 6C and ...
14
Paramagnetism & structural biology : biochemical & biophysical analysis of imp-1 metallo-beta-lactamase
... Of particular importance to this study was the ability to directly compare the [FeZn]IMP-1 structure with two structures of [ZnZn]IMP-1 at high resolution and with ligands bound to the active site. Only a single IMP-1 ...
221
Critical importance of the correction of contrast transfer function for transmission electron microscopy-mediated structural biology
... of structural alteration was most dramatic when π/2 phase shift from the correct CTF was imposed, causing local phase contrast reversal in the structure ...resolution structural features in the projection ...
7
The Structural Biology of HIV Budding and Maturation
... In this chapter, I discuss our analysis of the ESCRT structure using evidence from electron cryotomography of in vitro assemblies and dividing archaeal cells.. Our observations led to a [r] ...
163
Structural biology of induced conformational changes
... 1977. Immediately after his secondary education at College Blaucapel in Utrecht (1989-1995) he joined the Wageningen University. During his study Molecular Sciences he chose the combined microbiological/biochemical ...
137
Structural Biology of the Arterivirus nsp11 Endoribonucleases
... Interestingly, both sequence and structure analyses of nsp11 proteins revealed no sequence or structural homologs in the pig or horse. Therefore, NendoU may be a novel and promising drug target for arteriviruses, ...
14
Structural biology of Vibrio cholerae pathogenicity factors
... cholerae, structural and functional investigations of a hypothetical protein family present in pathogenicity islands and a transcriptional regulator protein for DNA-binding were ...
191
Shortest Geometric Paths Analysis in Structural Biology
... hyperthermophilic conditions, the proteins adopt a more spherical structure, namely they have greater Burial Depth, lesser Travel Depth, and higher Wadell sphericity than their mesostable counterparts. The interiors of ...
346