Structural changes of lymphocyte function associated antigen 1
Polymorphism of lymphocyte function associated antigen 1 demonstrated by a lupus patient's alloantiserum
... J Clin Invest. 1987;79(6):1607-1614. https://doi.org/10.1172/JCI112996. We have found a human serum, E27, obtained from a multiply transfused patient with systemic lupus erythematosus, which immunoprecipitates the ...
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Abnormal cytolytic activity of lymphocyte function associated antigen 1 deficient human cytolytic T lymphocyte clones
... the lymphocyte function-associated antigen-1 (LFA-1) membrane molecule in cytolytic T lymphocyte (CTL) interactions with lymphoid target cells was investigated using CTL ...
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Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells
... integrin function, remains ...proteins associated with LFA-1 on in vitro cultured DCs that may constitute such signalling platforms we here used selective immuno-precipita- tion (IP) of LFA-1 ...
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A monoclonal antibody against lymphocyte function associated antigen 1 decreases HIV 1 replication by inducing the secretion of an antiviral soluble factor
... Incubating PBMC with LFA-1 MAb for 24 hours resulted in the production of a soluble factor that inhibited HIV-1 replication. Given the cells that LFA-1 MAb binds and the short period of incubation, ...
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Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function associated antigen 1 expression and function
... M L Hibbs, … , T M Roberts, T A Springer J Clin Invest. 1990;85(3):674-681. https://doi.org/10.1172/JCI114491. Leukocyte adhesion deficiency (LAD) is an inherited immunodeficiency disease that is characterized by the ...
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Leukocyte function associated antigen 1 (LFA 1) and CD44 are signalling molecules for cytoskeleton dependent morphological changes in activated T cells
... (a) and (b) show resting and 3-clay-activated cells stained with the isotype-specific second antibody alone; (c) (unstimulated) and (d) (stimulated) demonstrate T cells stained using the[r] ...
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The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical Relevance
... I antigen processing and presentation pathway can be identified by measuring the MHC class I surface expression, which can be either down- regulated or totally ...
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CiteSeerX — Brief Definitive Report The Use of Lymphocyte Function–associated Antigen (LFA)-1–deficient Mice to Determine the Role of LFA-1, Mac-1, and �4 Integrin in the Inflammatory Response
... integrins, lymphocyte function–associated antigen (LFA)-1, and ...mice, function blocking monoclonal antibodies, and intravital microscopy to inves- tigate the roles of ...
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Mechanisms of drug induced lupus II T cells overexpressing lymphocyte function associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice
... This suggests that LFA-1 overexpression contributes to the au- toreactivity, and inhibiting function of the additional mole- cules reverses it (8). Cloned human T cells transfected with a CD18 cDNA also ...
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Bare lymphocyte syndrome Consequences of absent class II major histocompatibility antigen expression for B lymphocyte differentiation and function
... bare lymphocyte syndrome is a rare combined immunodeficiency disorder associated with the absence of class I and/or class II major histocompatibility (MHC) ...
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Evidence that measles virus hemagglutinin initiates modulation of leukocyte function-associated antigen 1 expression.
... protein-induced changes in LFA-1 expression and leukocyte aggregation were initiated by adding 2 3 10 5 U937 cells to V-bottom tubes and centrifuging the tubes at 400 3 ...of 1 mg of purified peptide ...
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Changes of DNA methylation are associated with changes in lung function during adolescence
... lung function development in adolescence, such as gen- der reversal of asthma incidence in males and ...epigenetic changes in structural cells of the ...DNA-M changes with lung function ...
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HIV-associated structural brain changes as related to cognition
... Tkmedit function in the Freesurfer package (Illustrated in Figure ...cost function based registration between each participant’s lowb volume and the T2 template provided by the Montreal Neurological ...
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Relation of impaired lymphocyte proliferative function to other major human immunodeficiency virus type 1-induced immunological changes.
... type 1 (HIV-1) induces impairment of immune function reflected in reduced lymphocyte proliferative ...immune changes are induced by HIV-1, but their relationship to ...
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Ostermann, Georg (2002): Identification of junctional adhesion molecule (JAM)-1 as a novel immunoglobulin superfamily ligand for lymphocyte function-associated antigen (LFA)-1. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... β 1 integrin (α 4 β 1 ), in cellular interactions with T lymphocytes (Cunningham et ...domain 1 of JAM-2, in contrast to the requirement for the membrane-proximal domain 2 of JAM-1 to bind to ...
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ARHGEF1 deficiency reveals Gα13 associated GPCRs are critical regulators of human lymphocyte function
... and lower respiratory tract infections, depressed serum concentrations of IgG, and, in one sibling, reduced IgA and IgE levels. Notably, neither sibling harbored measurable antibody titers against pro- tein and viral ...
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Deficient antigen presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome
... studied antigen-presenting cell (APC) function in DR- transfected BLS cells derived from multiple complementation ...in antigen presentation, was reduced or absent in the BLS ...II structural ...
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Differential Effects of Immunosuppressants on Lymphocyte Function
... was associated with a reduction in peripheral blood and tissue lymphocytes and impaired responses to PHA by residual lymph node ...on antigen-reactive lymphocytes, all three drugs ...
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White Matter Structural Connectivity is Associated with Sensorimotor Function in Stroke Survivors
... the structural changes across the entire ...FA changes in white matter tracts that correlate to upper extremity func- tion ( Schaechter and Fricker, 2009 ...
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Cytotoxic T lymphocyte antigen 4 and immune checkpoint blockade
... T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory ...cell function and antitumor responses in ...
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