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Subchondral bone changes in osteoarthritis

Instability and excessive mechanical loading mediate subchondral bone changes to induce osteoarthritis

Instability and excessive mechanical loading mediate subchondral bone changes to induce osteoarthritis

... produce subchondral bone thickening in intact joints and that load- induced subchondral bone thickening is further accentuated in regions underlying cartilage ...reveals bone ...

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Original Article Subchondral bone changes and chondrogenic capacity of progenitor cells from subchondral bone in the collagenase-induced temporomandibular joints osteoarthritis rabbit model

Original Article Subchondral bone changes and chondrogenic capacity of progenitor cells from subchondral bone in the collagenase-induced temporomandibular joints osteoarthritis rabbit model

... the subchondral bone repair reactions in the collagenase-induced TMJOA rabbit ...and subchondral bone had not obvious, or dis- ...chondral bone region. Notably, chondroid metaplasia in ...

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A role for subchondral bone changes in the process of osteoarthritis; a micro CT study of two canine models

A role for subchondral bone changes in the process of osteoarthritis; a micro CT study of two canine models

... cortical bone changes or any osteophytes were found at 3 weeks post-surgery in the groove ...the subchondral plate decreased very consistently in two different canine models of osteoarthri- tis: the ...

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The role of subchondral bone in osteoarthritis

The role of subchondral bone in osteoarthritis

... involved. Subchondral bone refers to the bone directly beneath the articular ...joint. Subchondral bone changes are thought to occur at early stages of ...role subchondral ...

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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

... Conclusion Subchondral bone is an intricate structure consisting of a dome-like subchondral plate and underlying trabeculae, which enjoys a close biomechanical and biochemical rela- tionship with ...

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The role of subchondral bone in osteoarthritis

The role of subchondral bone in osteoarthritis

... visualise bone and are insensitive to structural pathology and longitudinal change in ...structural changes are poorly correlated with the clinical ...

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Subchondral bone remodelling in osteoarthritis

Subchondral bone remodelling in osteoarthritis

... hypertrophic changes in the subchondral bone seen on plain ...osteophytes, subchondral sclerosis and subchondral ...the subchondral bone. The advent of MRI scanning has ...

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Subchondral bone abnormalities in knee osteoarthritis

Subchondral bone abnormalities in knee osteoarthritis

... 123 OA has traditionally been recognised as a non-inflammatory form of arthritis, driven by progressive deterioration of the entire joint [223]. However, increased numbers of studies have suggested that systemic ...

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Genome wide expression profiles of subchondral bone in osteoarthritis

Genome wide expression profiles of subchondral bone in osteoarthritis

... in subchondral bone specimens The regions of interest of subchondral bone samples ground for the gene expression study were about 5 mm deep under the calcified cartilage, which included the ...

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Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

... joint changes are observed frequently with these ...during subchondral bone remod- eling recruits mesenchymal stem cells for aberrant bone forma- tion and angiogenesis, which is a key step in ...

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Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density

Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density

... analyze subchondral cysts at the proximal tibia of OA patients to determine relationships between subchondral cyst parameters and clinical characteristics of ...disease-associated changes in tibial ...

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Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

... investigate bone in addition to cartilage by systematically collecting the tibial plateau slice contain- ing both articular cartilage and the underlying subchon- dral ...specific changes within a ...lected ...

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Quantitative evaluation of subchondral bone microarchitecture in knee osteoarthritis using 3T MRI

Quantitative evaluation of subchondral bone microarchitecture in knee osteoarthritis using 3T MRI

... becular bone microarchitecture and cartilage morphology in living patients with ...OA subchondral bone microstructure was deteriorated in both femoral condyles, and as increased severity of OA, ...

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Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis

Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis

... cause changes in patellar tra- becular bone, and compared to the metaphysis, caused only mild changes in epiphyseal trabecular ...increased bone volume fraction, suggesting that these sites ...

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Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics

Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics

... of Subchondral Cysts in a pre-clinical model of OA In this chapter, the development of subchondral cysts (SBC) is monitored longitudinally in a rodent model of knee ...the bone and soft tissue ...

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Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis

Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis

... MSC bone remodeling & other activities in OA As mentioned above, subchondral bone abnormalities observed in OA, such as subchondral plate thickening, osteo- phyte formation and particularly ...

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Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

... between bone structural, remodelling and molecular parameters in our animal model indicate that alterations in systemic and local remodelling lead to changes at the structural and bio- mechanical level at ...

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Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study.

Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study.

... similar changes in both, so it is reasonable to assume similar structural correlates for the texture features derived from the MRI sequence used in this study [ 22 ...MR subchondral bone texture as ...

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Phenotype changes of subchondral plate osteoblasts based on a rat model of ovariectomy induced osteoarthritis

Phenotype changes of subchondral plate osteoblasts based on a rat model of ovariectomy induced osteoarthritis

... in bone turnover, this study focused on phenotype changes of ...while subchondral osteoblast changes in OVX-OA rats have yet been ...in bone remodeling, we speculated that phenotype ...

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In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT

In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT

... 2010 Osteoarthritis Research Society ...Introduction Osteoarthritis (OA) is a disease characterized by cartilage attri- tion and joint ...of subchondral bone in the etiology of OA has long ...

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