Surfactant protein C
Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia
... that C/EBPα is extensively expressed in AEC II, airway epithelial cells, and lung macrophages during the vesicular and alveolar phases of lung development; the abnormal expression of C/EBPα in lung cells ...
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Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult rabbits
... Subsequently, surfactant therapy was adminis- tered as a bolus two times, the second bolus 45 min after first dose, in an effort to overcome potential surfactant ...C33Leu surfactant improved lung ...
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The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation
... lung surfactant lipids is very closely linked to the expression of the hydropho- bic surfactant proteins in AT2 cells ...lung surfactant activity and has the ability to penetrate directly into ...
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Development of a Synthetic Surfactant Using a Surfactant Protein C Peptide Analog: In Vitro Studies of Surface Physical Properties
... Most of the commercially used artificial PSs are derived from animal (cow or pig) lung tissue. These animal-derived PSs con- tain surfactant protein (SP) from animal lung extracts, a point that raises ...
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Childhood interstitial lung disease due to surfactant protein C deficiency: frequent use and costs of hospital services for a single case in Australia
... Following a clomiphene assisted conception, an unevent- ful pregnancy and delivery of a female infant ensued. The infant was initially admitted to a small regional hos- pital outside of Sydney at 21 days of age for ...
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Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury
... abundant surfactant associated lipoprotein expressed in alveolar type II epithelial cells that synthesize and secrete pulmonary surfactant into the air- ...structure, protein expression, or ...
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Clinical and genetic spectrum of interstitial lung disease in Chinese children associated with surfactant protein C mutations
... were reported [8–10]. Whether patients with different geographic and ethnic origins differ in clinical and gen- etic spectrum remains unclear. With the increase of awareness of this disease and advances in diagnostic ...
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Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
... encoding surfactant protein C (SP-C), which is expressed exclusively in type II alveolar epithe- lial ...the C-terminal por- tion (or BRICHOS domain) of pro–SP-C result in ...
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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
... of surfactant homeostasis are a rare cause of respiratory failure in newborns and infants ...encoding surfactant protein-B (SP-B) [2,3] and ABCA3, which encodes ATP-binding cassette transporter A3 ...
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Population-Based Estimates of Surfactant Protein B Deficiency
... of surfactant protein B, one of us ...of surfactant pro- teins A, B, and proSP-C in lung tissue from all 14 available ...detectable surfactant protein B, had increased staining ...
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Culture of human alveolar epithelial type II cells by sprouting
... (Abcam), surfactant protein C (SP-C) (ThermoFisher Scientific), overnight at 4 °C in moist box; for LysoTracker® Green DND-26 (Cell Signaling Technologies, USA) cells were incu- bated ...
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Engineering novel complement activity into a pulmonary surfactant protein
... Three new recombinant constructs were created in which all or part of the MASP-binding motif was introduced into the collagenous domain of SP-A (Fig. 4). Changes were made five Gly-Xaa-Yaa triplets towards the ...
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On the significance of Surfactant Protein-A within the human lungs
... [2]. Surfactant is a complex mixture of lipids, carbohydrates and four proteins (SP-A, SP-B, SP-C, ...of surfactant lead back to the 1950s, but little attention was given to the surfactant ...
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Surfactant protein-D and pulmonary host defense
... Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the ...specific ...
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Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease
... Crim C, Duvoix A, Fauerbach PN, Lomas DA, Macnee W, Mayer RJ, Miller BE, Müller NL, Rennard SI, Silverman EK, Tal-Singer R, Wouters EF, Vestbo J, Evaluation of COPD Longitudinally to Identify Predictive Surrogate ...
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Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
... We demonstrated an elevated expression of SP-D in air- ways of asthmatics compared to that of non-asthmatics in lung tissue sections and ALI cultures, a model for epithelial differentiation. The increased expression of ...
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Surfactant protein A enhances respiratory syncytial virus clearance in vivo
... sity, Nashville, Tennessee, USA). RSV was plaque- purified three times under agarose. The third plaque was inoculated into a subconfluent HEp-2 cell monolayer. After adsorption for 1 h at room tem- perature, 10% EMEM was ...
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Role of alveolar type II cells and of surfactant-associated protein C mRNA levels in the pathogenesis of respiratory distress in mink kits infected with Aleutian mink disease parvovirus.
... 2720-2725 0022-538X/94/$04.00+0 Copyright X 1994, American Society for Microbiology NOTES Role of Alveolar Type II Cells and of Surfactant-Associated Protein C mRNA Levels in the Pathoge[r] ...
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The Role of Protein C, Protein S, and Resistance to Activated Protein C in Legg-Perthes Disease
... was not specified. The inclusion of blacks among their controls, but not cases, partially accounts for the low prevalence of the factor V mutation in their controls and their very large OR. We cannot explain why findings ...
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Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
... regulating surfactant homeostasis in the lungs by modulating surfactant ultra- structure and promoting reuptake of surfactant by type II pneumocytes ...
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