synaptic vesicles
Optogenetic acidification of synaptic vesicles and lysosomes
... reluctant” vesicles that were not discharged during the incubation with Baf because of their intrinsically low release ...of synaptic vesicles, we were able to titrate the vesicular glutamate content ...
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Sentryn Acts with a Subset of Active Zone Proteins To Optimize the Localization of Synaptic Vesicles in Caenorhabditis elegans
... ABSTRACT Synaptic vesicles (SVs) transmit signals by releasing neurotransmitters from specialized synaptic regions of ...the synaptic region, SVs are tightly clustered around small structures ...
22
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
... trafficking 10, 11 . Syb2 and VAMP4 are highly homologous in their SNARE motifs and C- terminal regions, but possess unique N-terminal sequences. VAMP4 has a longer N-terminal region, which contains a di-leucine motif ...
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A mutation in protein kinase C gamma alters SNC neuron morphology and decreases synaptic vesicles in dopaminergic striatal terminals in the AS/AGU rat
... dopaminergic synaptic terminals within the ...the synaptic vesicles of AS controls; this was not only true of “readily-releasable” zones adjacent to the synaptic cleft but also “storage pool” ...
8
Exocytotic steps in cell-free system after cholesterol deprivation in synaptosomal plasma membranes and synaptic vesicles
... На відміну від викладеного вище, за знач- ного видалення холестеролу із плазматичної мембрани синаптосом (зменшенні на 25%) рівень Са 2+ -індукованого злиття їх із СВ не відрізняється[r] ...
12
Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
... to vesicles membranes either in its own right or through interaction with partner ...in synaptic vesicles to minimise cytosolic degradation and free radical ...into synaptic storage ...
12
Impaired dopamine metabolism in Parkinson’s disease pathogenesis
... in synaptic vesicles, DA undergoes auto- oxidation, resulting in oxidative stress ...the synaptic damage likely precede neuronal death and disease ...
21
Neurodegenerative changes initiated by presynaptic dysfunction
... pre- synaptic dysfunctions ...exocytosed synaptic vesicles occurs in the periactive zone, a region adjacent to the active zone where synaptic vesicle is endo- cytosed ...
5
Membrane energization by proton pumps is important for compartmentalization of drugs and toxins: a new type of active transport
... of ∆Ψ, had no effect or was slightly stimulatory, indicating that ∆pH, but not ∆Ψ, is a driving force for the uptake. The ATP- dependent uptake was insensitive to reserpine, tetrabenazine, imipramine (inhibitors of ...
8
The role of V ATPase in neuronal and endocrine systems
... We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: 1 structural aspects of V-ATPase; 2 energy coupling of transport of transmitters; 3 reconstitu[r] ...
9
Synaptic Odyssey
... of synaptic contacts (red) made by the climbing fiber (blue, ...with vesicles (solid blue), mitochondria (beige), and synapses ...docked vesicles for climbing fibers (CF) and parallel fibers ...clear ...
20
A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila
... post- synaptic homeostatic response to defects in neurotransmis- sion, given that Dmon1 D181 mutants have smaller synaptic ...smaller synaptic vesicles does not lead to any change in GluRIIA ...
19
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila
... docked synaptic vesicles must fuse with the plasma membrane and release neurotransmitter into the synaptic cleft via ...for synaptic transmission is endocytosis, in which the plasma membrane ...
18
The storage and release of acetylcholine at the mammalian neuromuscular junction
... The effect of potassium in increasing the quantal content of e.p.p.s at the neuromuscular junction has been noted by several investigators (Liley, 1956c; Takeuchi and Takeuchi, 19^1; Edwards and Ikeda, 1962; Parsons, ...
283
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
... of synaptic vesicles, which is suggestive for a protein able to reversibly and transiently interact with SVs ...synaptophysin-positive vesicles in human iPSC derived motor ...
17
Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease
... of synaptic vesicles ...Notably, synaptic strength is dependent upon the 3rd-4th power of [Ca 2+ ] [108], and this steep power function is a critical variable influencing plasticity defects in AD ...
21
Synaptic like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones
... and synaptic ribbon regions, where are thought to be the sites of some secretory ...clear vesicles with a diameter of 50–70 nm ...of synaptic vesicles, but contain synaptic vesicle ...
9
Immature Synaptic Contacts in Human Congenital Hydrocephalus. An Electron Microscopic study
... immature synaptic contacts, and axonal and dendritic grow cones the axodendritic contacts appeared formed by extremely swollen pre- and postsynaptic endings due to the hydrocephalic edema (Figure ...postsynaptic ...
8
Interaction of Cryptococcus neoformans Extracellular Vesicles with the Cell Wall
... Using this method, we purified populations that we named by their total centrifugation time (1-h historical control or 5 min, 10 min, 20 min, and 60 min; in this nomenclature the 1 h represents the vesicle preparation ...
10
Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents
... monitored synaptic transmis- sion and plasticity of that transmission in cross-sectional studies of pre-plaque TG rats and longitudinally in indi- vidual animals over several ...baseline synaptic ...
15